CRCGN015_MCF10A.TP53.M_24H:H18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 11.05 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADAT1 adenosine deaminase, tRNA-specific 1 5.13655
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 4.10775
VAV3 vav 3 guanine nucleotide exchange factor 3.82897
POLR1D polymerase (RNA) I polypeptide D, 16kDa 3.17712
HBB hemoglobin, beta 2.72028
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.52892
PARK7 parkinson protein 7 2.5079
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.46805
COQ8A coenzyme Q8A 2.45365
MEST mesoderm specific transcript 2.359
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.3109
PRB3 proline-rich protein BstNI subfamily 3 2.1957
PLSCR3 phospholipid scramblase 3 2.18252
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.1231
COPS7A COP9 signalosome subunit 7A 2.12025
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.1086
VRTN vertebrae development associated 2.10805
DPT dermatopontin 2.10402
PRH1 proline-rich protein HaeIII subfamily 1 2.04595
NOP2 NOP2 nucleolar protein 2.0296
NOP14 NOP14 nucleolar protein 2.0295
CDH22 cadherin 22, type 2 2.0146
NPIPB6 nuclear pore complex interacting protein family, member B6 2.01455
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 2.01315
KCNK10 potassium channel, two pore domain subfamily K, member 10 2.0089
TUBA8 tubulin, alpha 8 2.00135

decreased expression

Symbol Name Standardized Value
ZDHHC6 zinc finger, DHHC-type containing 6 -5.2144
HMG20B high mobility group 20B -4.9856
VDAC1 voltage-dependent anion channel 1 -4.70727
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.69313
ATF5 activating transcription factor 5 -2.67913
INSIG1 insulin induced gene 1 -2.56225
DDA1 DET1 and DDB1 associated 1 -2.4593
DDIT4 DNA-damage-inducible transcript 4 -2.45275
SREBF1 sterol regulatory element binding transcription factor 1 -2.41865
MAP2K2 mitogen-activated protein kinase kinase 2 -2.3044
DNM1 dynamin 1 -2.26225
OCEL1 occludin/ELL domain containing 1 -2.17895
DUSP14 dual specificity phosphatase 14 -2.0383
GRWD1 glutamate-rich WD repeat containing 1 -2.02785