CRCGN015_MCF10A.TP53.M_24H:H21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description estradiol 11.59 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 5.18725
MAP7 microtubule-associated protein 7 5.0751
HBA1 hemoglobin, alpha 1 4.24244
HBB hemoglobin, beta 4.06372
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.66845
AGR2 anterior gradient 2 3.39575
CDK19 cyclin-dependent kinase 19 3.339
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.9553
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.73975
ZNF329 zinc finger protein 329 2.73405
ZNF134 zinc finger protein 134 2.5762
PEX7 peroxisomal biogenesis factor 7 2.56183
COMP cartilage oligomeric matrix protein 2.42615
CORO1C coronin, actin binding protein, 1C 2.41585
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 2.4017
CETN3 centrin, EF-hand protein, 3 2.3272
ZNF551 zinc finger protein 551 2.3148
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.2864
TMEM14A transmembrane protein 14A 2.28345
THUMPD2 THUMP domain containing 2 2.27125
LXN latexin 2.2611
PYCR1 pyrroline-5-carboxylate reductase 1 2.2121
TTC27 tetratricopeptide repeat domain 27 2.19875
CAPN1 calpain 1, (mu/I) large subunit 2.1959
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.1926
SRFBP1 serum response factor binding protein 1 2.1863
NPR2 natriuretic peptide receptor 2 2.09282
UBE2N ubiquitin-conjugating enzyme E2N 2.07452
AK6 adenylate kinase 6 2.0706
CBFB core-binding factor, beta subunit 2.0669
INTS9 integrator complex subunit 9 2.0394
SFRP4 secreted frizzled-related protein 4 2.03848
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 2.02705
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.0263
PITPNB phosphatidylinositol transfer protein, beta 2.00405

decreased expression

Symbol Name Standardized Value
TSPAN4 tetraspanin 4 -10.0
HMG20B high mobility group 20B -10.0
KRT14 keratin 14, type I -5.52175
DSG2 desmoglein 2 -5.0769
TRAPPC3 trafficking protein particle complex 3 -4.74282
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -3.91747
DCK deoxycytidine kinase -3.6774
TCTA T-cell leukemia translocation altered -3.65405
MRPS15 mitochondrial ribosomal protein S15 -3.6492
LYPLA1 lysophospholipase I -3.58755
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.36015
ACAA1 acetyl-CoA acyltransferase 1 -3.00178
KDM3A lysine (K)-specific demethylase 3A -2.8882
MFSD12 major facilitator superfamily domain containing 12 -2.87995
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.82468
ATP11B ATPase, class VI, type 11B -2.7142
TKT transketolase -2.64182
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.5906
RAP2A RAP2A, member of RAS oncogene family -2.588
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -2.43983
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.43515
CLIP3 CAP-GLY domain containing linker protein 3 -2.3937
KRT17 keratin 17, type I -2.30743
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 -2.28055
IGSF3 immunoglobulin superfamily, member 3 -2.2774
RUSC2 RUN and SH3 domain containing 2 -2.22735
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -2.19375
MT1X metallothionein 1X -2.17788
LZTR1 leucine-zipper-like transcription regulator 1 -2.17135
MAP7D1 MAP7 domain containing 1 -2.16935
MSN moesin -2.1425
MT1G metallothionein 1G -2.1398
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -2.12365
IPO13 importin 13 -2.1215
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -2.114
AMOTL2 angiomotin like 2 -2.1051
AIRIM AFG2 interacting ribosome maturation factor -2.0984
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.095
WWC2 WW and C2 domain containing 2 -2.0925
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 -2.07065
PTPRM protein tyrosine phosphatase, receptor type, M -2.06565
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) -2.062
MTERF3 mitochondrial transcription termination factor 3 -2.06165
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.05785
PHC2 polyhomeotic homolog 2 (Drosophila) -2.05375
MYDGF myeloid-derived growth factor -2.03657
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -2.0287
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.0118
ARHGAP29 Rho GTPase activating protein 29 -2.0015