CRCGN015_MCF10A.TP53.M_24H:H22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description CH-223191 100.87 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

302 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 9.4119
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 8.1629
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 6.2923
AARS1 alanyl-tRNA synthetase 1 5.93635
HMOX1 heme oxygenase 1 5.928
SQSTM1 sequestosome 1 5.5792
PYCR1 pyrroline-5-carboxylate reductase 1 5.33725
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 5.20045
GET1 guided entry of tail-anchored proteins factor 1 4.8155
TNIP1 TNFAIP3 interacting protein 1 4.63045
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 4.3653
SOX4 SRY (sex determining region Y)-box 4 4.29956
IL1B interleukin 1, beta 4.2587
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.24735
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.2191
ASNS asparagine synthetase (glutamine-hydrolyzing) 4.17425
CXCL3 chemokine (C-X-C motif) ligand 3 4.03555
SNX11 sorting nexin 11 3.95345
KIF5C kinesin family member 5C 3.8996
ITFG1 integrin alpha FG-GAP repeat containing 1 3.8938
SARS1 seryl-tRNA synthetase 1 3.87835
HMGA2 high mobility group AT-hook 2 3.666
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 3.5032
EPHB2 EPH receptor B2 3.4722
HBA1 hemoglobin, alpha 1 3.45547
TRIB3 tribbles pseudokinase 3 3.4338
PHGDH phosphoglycerate dehydrogenase 3.42715
LOC102724560 cystathionine beta-synthase 3.4044
GARS1 glycyl-tRNA synthetase 1 3.4032
TRIB1 tribbles pseudokinase 1 3.30405
VAV3 vav 3 guanine nucleotide exchange factor 3.21102
GPATCH8 G patch domain containing 8 3.1943
ACAA1 acetyl-CoA acyltransferase 1 3.1788
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.1595
NFE2L1 nuclear factor, erythroid 2-like 1 3.0528
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.99245
PSAT1 phosphoserine aminotransferase 1 2.95685
STAMBP STAM binding protein 2.87315
AMOTL2 angiomotin like 2 2.8387
DUSP4 dual specificity phosphatase 4 2.82965
CDPF1 cysteine-rich, DPF motif domain containing 1 2.7298
RAB32 RAB32, member RAS oncogene family 2.7057
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.7009
LOC128125814 uncharacterized LOC128125814 2.6885
VSIG2 V-set and immunoglobulin domain containing 2 2.68372
FSD1 fibronectin type III and SPRY domain containing 1 2.6556
CARS1 cysteinyl-tRNA synthetase 1 2.64185
OXSR1 oxidative stress responsive 1 2.6279
ATF4 activating transcription factor 4 2.58705
POGK pogo transposable element with KRAB domain 2.55925
XPOT exportin, tRNA 2.53965
CHMP4B charged multivesicular body protein 4B 2.53205
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.53165
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 2.52422
CHMP7 charged multivesicular body protein 7 2.5238
TARS1 threonyl-tRNA synthetase 1 2.51135
GLRX glutaredoxin (thioltransferase) 2.50163
GTPBP2 GTP binding protein 2 2.4859
ACOT9 acyl-CoA thioesterase 9 2.4582
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 2.456
PYGB phosphorylase, glycogen; brain 2.4524
XPC xeroderma pigmentosum, complementation group C 2.42865
ST18 suppression of tumorigenicity 18, zinc finger 2.40615
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.40245
NARS1 asparaginyl-tRNA synthetase 1 2.39895
WARS1 tryptophanyl-tRNA synthetase 1 2.395
EPHA2 EPH receptor A2 2.38685
FHL2 four and a half LIM domains 2 2.37835
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.362
STC2 stanniocalcin 2 2.35895
EIF2D eukaryotic translation initiation factor 2D 2.3524
EGR1 early growth response 1 2.3504
ADGRG1 adhesion G protein-coupled receptor G1 2.31393
ACOT13 acyl-CoA thioesterase 13 2.2812
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.27165
CADM1 cell adhesion molecule 1 2.26048
MTMR14 myotubularin related protein 14 2.25975
MARS1 methionyl-tRNA synthetase 1 2.24557
GRB10 growth factor receptor-bound protein 10 2.23982
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.23201
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 2.22458
KLF11 Kruppel-like factor 11 2.2124
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 2.21
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.2033
CBR4 carbonyl reductase 4 2.20095
DYNLT3 dynein, light chain, Tctex-type 3 2.1877
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.1813
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.1809
SCCPDH saccharopine dehydrogenase (putative) 2.1792
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 2.17807
ACTMAP actin maturation protease 2.16205
CHIC2 cysteine-rich hydrophobic domain 2 2.1521
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.14615
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.1444
ALS2CL ALS2 C-terminal like 2.1284
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 2.1255
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.09835
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.07935
ICAM1 intercellular adhesion molecule 1 2.05563
PXDC1 PX domain containing 1 2.047
TBCE tubulin folding cofactor E 2.04595
LSR lipolysis stimulated lipoprotein receptor 2.03825
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.03135
LAMA5 laminin, alpha 5 2.02615
FNBP1L formin binding protein 1-like 2.0203
PGAP6 post-GPI attachment to proteins 6 2.01435
LRRC8D leucine rich repeat containing 8 family, member D 2.01355
ACSM2A acyl-CoA synthetase medium-chain family member 2A 2.0123
DENND10 DENN domain containing 10 2.0089
DCTN6 dynactin 6 2.007
ARID4B AT rich interactive domain 4B (RBP1-like) 2.0023

decreased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 -8.87835
MAPK13 mitogen-activated protein kinase 13 -5.77952
HOXA5 homeobox A5 -5.09925
TCTA T-cell leukemia translocation altered -4.95135
GOLT1B golgi transport 1B -4.66275
DIPK1A divergent protein kinase domain 1A -4.63905
JMJD6 jumonji domain containing 6 -4.46365
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -4.19245
ADI1 acireductone dioxygenase 1 -3.7248
MED21 mediator complex subunit 21 -3.63028
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.56435
S100A4 S100 calcium binding protein A4 -3.4566
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.39985
RECQL RecQ helicase-like -3.36811
PRR15L proline rich 15-like -3.34755
MXRA7 matrix-remodelling associated 7 -3.34425
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.1769
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -3.14665
SRSF2 serine/arginine-rich splicing factor 2 -3.12473
DBF4 DBF4 zinc finger -3.0627
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -3.01695
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -3.01667
CDK1 cyclin-dependent kinase 1 -2.98025
PTS 6-pyruvoyltetrahydropterin synthase -2.96765
ELAC2 elaC ribonuclease Z 2 -2.92615
ELOVL6 ELOVL fatty acid elongase 6 -2.85005
ETNK1 ethanolamine kinase 1 -2.84942
STAT1 signal transducer and activator of transcription 1, 91kDa -2.83757
BORCS8 BLOC-1 related complex subunit 8 -2.8152
ALDOC aldolase C, fructose-bisphosphate -2.77805
GAS1 growth arrest-specific 1 -2.77747
CRYZ crystallin, zeta (quinone reductase) -2.77655
GRWD1 glutamate-rich WD repeat containing 1 -2.7709
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.76995
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.7445
ZBP1 Z-DNA binding protein 1 -2.7292
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough -2.72115
HOXC4 homeobox C4 -2.7143
HOXA4 homeobox A4 -2.6923
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.6912
MAGEA8 melanoma antigen family A8 -2.6777
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.65325
PTGFR prostaglandin F receptor (FP) -2.6442
PGRMC1 progesterone receptor membrane component 1 -2.61048
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.6058
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.60432
RPA3 replication protein A3, 14kDa -2.59435
SUZ12 SUZ12 polycomb repressive complex 2 subunit -2.59197
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.59015
ZNF274 zinc finger protein 274 -2.55975
CREBZF CREB/ATF bZIP transcription factor -2.55896
HOXC6 homeobox C6 -2.54715
TPST1 tyrosylprotein sulfotransferase 1 -2.5347
SAP30BP SAP30 binding protein -2.5342
ZDHHC6 zinc finger, DHHC-type containing 6 -2.53155
YAF2 YY1 associated factor 2 -2.528
STXBP2 syntaxin binding protein 2 -2.52665
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.5199
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.50005
KRT14 keratin 14, type I -2.49865
LPCAT3 lysophosphatidylcholine acyltransferase 3 -2.4938
REXO2 RNA exonuclease 2 -2.4891
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.478
MADD MAP-kinase activating death domain -2.47465
ACSL5 acyl-CoA synthetase long-chain family member 5 -2.47335
STK25 serine/threonine kinase 25 -2.47105
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.45773
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.4534
CDK20 cyclin-dependent kinase 20 -2.4455
INTS13 integrator complex subunit 13 -2.43805
AQP3 aquaporin 3 (Gill blood group) -2.43278
ADORA3 adenosine A3 receptor -2.43035
SESN1 sestrin 1 -2.4278
SPATA6 spermatogenesis associated 6 -2.42753
TSPAN3 tetraspanin 3 -2.4272
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.41925
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.40608
NCAM2 neural cell adhesion molecule 2 -2.40365
COPS7B COP9 signalosome subunit 7B -2.40155
CBR3 carbonyl reductase 3 -2.39725
TMEM50A transmembrane protein 50A -2.39525
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.3825
IFT46 intraflagellar transport 46 -2.3813
IKZF5 IKAROS family zinc finger 5 (Pegasus) -2.38105
DPT dermatopontin -2.37875
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.37095
IPO8 importin 8 -2.35955
PLPPR4 phospholipid phosphatase related 4 -2.3476
SPTBN2 spectrin, beta, non-erythrocytic 2 -2.3443
STEAP4 STEAP family member 4 -2.34085
TK1 thymidine kinase 1, soluble -2.3397
BTN2A1 butyrophilin, subfamily 2, member A1 -2.33097
FHL5 four and a half LIM domains 5 -2.32905
NDC1 NDC1 transmembrane nucleoporin -2.3161
ERGIC2 ERGIC and golgi 2 -2.30985
SCGB1D1 secretoglobin, family 1D, member 1 -2.3071
DPY19L1 dpy-19-like 1 (C. elegans) -2.29565
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.2939
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.2931
CORO7-PAM16 CORO7-PAM16 readthrough -2.2884
SNX7 sorting nexin 7 -2.2879
NCF4 neutrophil cytosolic factor 4, 40kDa -2.28785
FPGS folylpolyglutamate synthase -2.2857
ARMC7 armadillo repeat containing 7 -2.2763
BPIFA1 BPI fold containing family A, member 1 -2.27325
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.2725
IRX5 iroquois homeobox 5 -2.27035
GZMK granzyme K (granzyme 3; tryptase II) -2.26345
GAN gigaxonin -2.261
MPZL1 myelin protein zero-like 1 -2.25906
SRSF8 serine/arginine-rich splicing factor 8 -2.25883
ST14 suppression of tumorigenicity 14 (colon carcinoma) -2.25863
PLK1 polo-like kinase 1 -2.25855
ADGRB3 adhesion G protein-coupled receptor B3 -2.2513
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -2.24255
CENPX centromere protein X -2.24215
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) -2.2357
MX2 MX dynamin-like GTPase 2 -2.2338
LTK leukocyte receptor tyrosine kinase -2.23187
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.228
HSPB1 heat shock 27kDa protein 1 -2.22655
FFAR2 free fatty acid receptor 2 -2.22545
GTF2A1 general transcription factor IIA, 1, 19/37kDa -2.2172
HSPB11 heat shock protein family B (small), member 11 -2.21688
MOXD1 monooxygenase, DBH-like 1 -2.21405
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.2108
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough -2.2015
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -2.19975
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 -2.1995
SLC25A40 solute carrier family 25, member 40 -2.18955
IRF3 interferon regulatory factor 3 -2.1891
SLITRK3 SLIT and NTRK-like family, member 3 -2.17185
GTPBP8 GTP-binding protein 8 (putative) -2.16855
KCTD2 potassium channel tetramerization domain containing 2 -2.16705
LOC124904395 uncharacterized LOC124904395 -2.16626
CCDC91 coiled-coil domain containing 91 -2.1641
SKAP2 src kinase associated phosphoprotein 2 -2.16398
CCND3 cyclin D3 -2.1634
CD8B CD8b molecule -2.15545
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.1553
GOLGA8A golgin A8 family, member A -2.1515
FOXM1 forkhead box M1 -2.148
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -2.148
CISD1 CDGSH iron sulfur domain 1 -2.1385
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.1347
LBR lamin B receptor -2.13445
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.1288
EFNB2 ephrin-B2 -2.12435
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase -2.11935
TSPYL2 TSPY-like 2 -2.11795
DLAT dihydrolipoamide S-acetyltransferase -2.10883
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.1073
HOXA1 homeobox A1 -2.10635
CD248 CD248 molecule, endosialin -2.10625
TMEM248 transmembrane protein 248 -2.10315
OLFML3 olfactomedin-like 3 -2.10065
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -2.09845
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.0962
ACVR2A activin A receptor, type IIA -2.09545
CGRRF1 cell growth regulator with ring finger domain 1 -2.09215
REEP1 receptor accessory protein 1 -2.09162
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.09155
ING1 inhibitor of growth family, member 1 -2.09102
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.08975
EML4 echinoderm microtubule associated protein like 4 -2.0894
TEX30 testis expressed 30 -2.0877
MTUS2 microtubule associated tumor suppressor candidate 2 -2.0861
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.08477
PIMREG PICALM interacting mitotic regulator -2.08125
ZBTB24 zinc finger and BTB domain containing 24 -2.07815
ASTN1 astrotactin 1 -2.0728
BIRC5 baculoviral IAP repeat containing 5 -2.06895
CXCR3 chemokine (C-X-C motif) receptor 3 -2.0602
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.0581
CD164 CD164 molecule, sialomucin -2.05448
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase -2.05268
PGAM4 phosphoglycerate mutase family member 4 -2.0491
MCOLN1 mucolipin 1 -2.04785
CTSW cathepsin W -2.0407
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.0279
TSPAN6 tetraspanin 6 -2.0274
OSTF1 osteoclast stimulating factor 1 -2.02545
CCDC186 coiled-coil domain containing 186 -2.023
TMEM123 transmembrane protein 123 -2.02245
TPGS1 tubulin polyglutamylase complex subunit 1 -2.01995
ELAVL2 ELAV like neuron-specific RNA binding protein 2 -2.0146
DPF1 D4, zinc and double PHD fingers family 1 -2.0129
GFER growth factor, augmenter of liver regeneration -2.0118
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.0115
KRT10 keratin 10, type I -2.00973
CATSPERH catsper channel auxiliary subunit eta -2.0037