CRCGN015_MCF10A.TP53.M_24H:H23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description CH-223191 33.62 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:H23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.20264
C2CD2 C2 calcium-dependent domain containing 2 4.9358
MAMLD1 mastermind-like domain containing 1 4.80775
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 4.782
ABHD6 abhydrolase domain containing 6 4.7287
SSBP2 single-stranded DNA binding protein 2 4.071
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.52925
MDM4 MDM4, p53 regulator 2.99805
COMP cartilage oligomeric matrix protein 2.875
MTA2 metastasis associated 1 family, member 2 2.83745
FOS FBJ murine osteosarcoma viral oncogene homolog 2.64715
STRN3 striatin, calmodulin binding protein 3 2.57157
STAMBP STAM binding protein 2.3836
RBBP5 retinoblastoma binding protein 5 2.2718
ACOT13 acyl-CoA thioesterase 13 2.25085
SCG2 secretogranin II 2.2461
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.2455
GPATCH2L G patch domain containing 2-like 2.2098
SRP9 signal recognition particle 9kDa 2.1966
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 2.16755
WDR76 WD repeat domain 76 2.14705
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.1426
EXOC5 exocyst complex component 5 2.12185
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.08665
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.06402
ITGA7 integrin, alpha 7 2.04245
SOX3 SRY (sex determining region Y)-box 3 2.0246
SKIC8 SKI8 subunit of superkiller complex 2.01285

decreased expression

Symbol Name Standardized Value
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -4.8144
SGK1 serum/glucocorticoid regulated kinase 1 -3.904
HSPA1A heat shock 70kDa protein 1A -3.7186
CAB39 calcium binding protein 39 -2.9912
ACAA1 acetyl-CoA acyltransferase 1 -2.925
COTL1 coactosin-like F-actin binding protein 1 -2.6967
IER3 immediate early response 3 -2.66055
CDC25B cell division cycle 25B -2.6328
GRWD1 glutamate-rich WD repeat containing 1 -2.5973
FAIM Fas apoptotic inhibitory molecule -2.58395
SORBS3 sorbin and SH3 domain containing 3 -2.23108
FPGS folylpolyglutamate synthase -2.16045
TICAM1 toll-like receptor adaptor molecule 1 -2.09615
RBM15B RNA binding motif protein 15B -2.00265