CRCGN015_MCF10A.TP53.M_24H:I03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzyl-alcohol 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

134 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 7.5649
CNRIP1 cannabinoid receptor interacting protein 1 6.82656
FGFR4 fibroblast growth factor receptor 4 5.90566
SNAP25 synaptosomal-associated protein, 25kDa 4.76649
KDM5D lysine (K)-specific demethylase 5D 4.75127
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.62201
NRBF2 nuclear receptor binding factor 2 4.26545
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 4.04381
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 3.56966
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.55748
GPER1 G protein-coupled estrogen receptor 1 3.22862
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.20941
USP9Y ubiquitin specific peptidase 9, Y-linked 3.20832
FAM32A family with sequence similarity 32, member A 3.20717
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.02311
SSBP2 single-stranded DNA binding protein 2 2.9869
GSTT1 glutathione S-transferase theta 1 2.88655
MAP7 microtubule-associated protein 7 2.88061
KDM5A lysine (K)-specific demethylase 5A 2.76417
JMJD1C jumonji domain containing 1C 2.70291
CD247 CD247 molecule 2.67894
DOCK1 dedicator of cytokinesis 1 2.65083
TRAPPC8 trafficking protein particle complex 8 2.63174
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.62209
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.61917
ZFY zinc finger protein, Y-linked 2.555
ZNF197 zinc finger protein 197 2.54625
RNASE4 ribonuclease, RNase A family, 4 2.52307
LRRN3 leucine rich repeat neuronal 3 2.52009
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.51937
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.51533
TENT4A terminal nucleotidyltransferase 4A 2.48742
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 2.46716
SPTSSA serine palmitoyltransferase, small subunit A 2.46254
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.43835
HOPX HOP homeobox 2.43115
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.42706
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.38525
RET ret proto-oncogene 2.37842
EAPP E2F-associated phosphoprotein 2.37297
KANSL2 KAT8 regulatory NSL complex subunit 2 2.36134
MRGBP MRG/MORF4L binding protein 2.36051
STK38L serine/threonine kinase 38 like 2.36038
CAB39L calcium binding protein 39-like 2.34482
IMPACT impact RWD domain protein 2.34183
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.33067
NCAN neurocan 2.32329
AIRIM AFG2 interacting ribosome maturation factor 2.30202
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.30127
NTF3 neurotrophin 3 2.29616
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.2889
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.28764
HMGB3 high mobility group box 3 2.28688
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.26695
OCA2 oculocutaneous albinism II 2.25904
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.24323
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.24236
SOCS6 suppressor of cytokine signaling 6 2.22834
MEX3C mex-3 RNA binding family member C 2.20213
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.19558
AQP4 aquaporin 4 2.17947
CD101 CD101 molecule 2.1757
CD1B CD1b molecule 2.16456
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.15002
H2AJ H2A.J histone 2.14864
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 2.14493
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.13257
SNX16 sorting nexin 16 2.12894
MSMB microseminoprotein, beta- 2.11243
POLI polymerase (DNA directed) iota 2.10699
SERTAD2 SERTA domain containing 2 2.09663
ZNF22 zinc finger protein 22 2.09657
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.09563
FUBP3 far upstream element (FUSE) binding protein 3 2.08594
PVALB parvalbumin 2.08307
TBX21 T-box 21 2.0825
TRAPPC11 trafficking protein particle complex 11 2.07653
ACTL8 actin-like 8 2.05919
NSG2 neuronal vesicle trafficking associated 2 2.05736
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.05403
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.04952
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.04832
PEX7 peroxisomal biogenesis factor 7 2.04505
FBLN5 fibulin 5 2.0358
ALOX15 arachidonate 15-lipoxygenase 2.03475
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 2.02696
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.01768
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 2.00986
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.00707
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.00527
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.00393
EN1 engrailed homeobox 1 2.00357

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -6.4304
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.93588
HSPA1A heat shock 70kDa protein 1A -4.87028
HSPA8 heat shock 70kDa protein 8 -4.60213
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.36115
ACOT9 acyl-CoA thioesterase 9 -3.1005
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -3.07876
C2CD5 C2 calcium-dependent domain containing 5 -3.07166
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -3.02233
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.98102
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.91836
IFRD2 interferon-related developmental regulator 2 -2.68176
TEX10 testis expressed 10 -2.62826
SMC1A structural maintenance of chromosomes 1A -2.62269
TMED1 transmembrane emp24 protein transport domain containing 1 -2.56611
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.54714
HEATR1 HEAT repeat containing 1 -2.45456
COG2 component of oligomeric golgi complex 2 -2.4498
LAP3 leucine aminopeptidase 3 -2.42973
LUC7L LUC7-like (S. cerevisiae) -2.39315
DSE dermatan sulfate epimerase -2.35447
KDM5C lysine (K)-specific demethylase 5C -2.35417
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.29362
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -2.28193
USP21 ubiquitin specific peptidase 21 -2.26671
TBCA tubulin folding cofactor A -2.19711
FHIP2B FHF complex subunit HOOK interacting protein 2B -2.19665
BTN3A3 butyrophilin, subfamily 3, member A3 -2.18318
TTC4 tetratricopeptide repeat domain 4 -2.17377
NVL nuclear VCP-like -2.15537
TRIM25 tripartite motif containing 25 -2.13643
RRM2 ribonucleotide reductase M2 -2.10127
ETV4 ets variant 4 -2.09359
NFU1 NFU1 iron-sulfur cluster scaffold -2.06769
ZNF76 zinc finger protein 76 -2.06158
TMEM106C transmembrane protein 106C -2.05448
MSX1 msh homeobox 1 -2.04812
BGLAP bone gamma-carboxyglutamate (gla) protein -2.04567
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.04203
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) -2.03237
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -2.0233
RNF144A ring finger protein 144A -2.00896