CRCGN015_MCF10A.TP53.M_24H:I04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description monoethylhexylphthalate 100.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

125 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GARRE1 granule associated Rac and RHOG effector 1 6.05638
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.37395
ABHD6 abhydrolase domain containing 6 5.3294
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.27895
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.22082
TCTN1 tectonic family member 1 5.06069
E2F2 E2F transcription factor 2 4.99215
CDK19 cyclin-dependent kinase 19 4.8898
MYLK myosin light chain kinase 4.74846
ARID5B AT rich interactive domain 5B (MRF1-like) 4.38491
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 4.34873
TLR4 toll-like receptor 4 3.71822
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.36881
MTA2 metastasis associated 1 family, member 2 3.33313
CERK ceramide kinase 3.33066
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.18747
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 3.17312
NRBF2 nuclear receptor binding factor 2 3.14981
OXSR1 oxidative stress responsive 1 3.07099
KLF10 Kruppel-like factor 10 2.78492
ZNF286A zinc finger protein 286A 2.75955
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.75237
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.71779
ACTA2 actin, alpha 2, smooth muscle, aorta 2.70953
SRSF6 serine/arginine-rich splicing factor 6 2.6361
THRAP3 thyroid hormone receptor associated protein 3 2.61799
CCL2 chemokine (C-C motif) ligand 2 2.57534
TSPAN8 tetraspanin 8 2.53488
NKX2-2 NK2 homeobox 2 2.50304
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.46257
TRIM25 tripartite motif containing 25 2.46242
NOD2 nucleotide-binding oligomerization domain containing 2 2.4487
KDM7A lysine (K)-specific demethylase 7A 2.42117
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.37933
CALCB calcitonin-related polypeptide beta 2.3639
CEPT1 choline/ethanolamine phosphotransferase 1 2.36206
SORD sorbitol dehydrogenase 2.32276
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.32232
BPIFA1 BPI fold containing family A, member 1 2.24963
ERCC2 excision repair cross-complementation group 2 2.23472
SOCS6 suppressor of cytokine signaling 6 2.22222
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.21954
GUF1 GUF1 GTPase homolog (S. cerevisiae) 2.20001
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.18677
JAKMIP2 janus kinase and microtubule interacting protein 2 2.17516
PMP2 peripheral myelin protein 2 2.16732
TMEM209 transmembrane protein 209 2.16471
WSB2 WD repeat and SOCS box containing 2 2.16371
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 2.16182
GMIP GEM interacting protein 2.1618
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 2.14324
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.13807
NPR2 natriuretic peptide receptor 2 2.13731
TLR6 toll-like receptor 6 2.13661
CKAP2 cytoskeleton associated protein 2 2.12474
THAP11 THAP domain containing 11 2.10865
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.10633
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.10454
RAB4A RAB4A, member RAS oncogene family 2.09353
PSENEN presenilin enhancer gamma secretase subunit 2.09164
DSG1 desmoglein 1 2.09147
MCUR1 mitochondrial calcium uniporter regulator 1 2.09135
MNT MAX network transcriptional repressor 2.07891
PTPRE protein tyrosine phosphatase, receptor type, E 2.07082
MSX1 msh homeobox 1 2.06217
VANGL1 VANGL planar cell polarity protein 1 2.05084
PAQR6 progestin and adipoQ receptor family member VI 2.04307
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.03774
MDM4 MDM4, p53 regulator 2.02787
LYRM1 LYR motif containing 1 2.02001
RAB3D RAB3D, member RAS oncogene family 2.01515
BCL3 B-cell CLL/lymphoma 3 2.00588
HSPB1 heat shock 27kDa protein 1 2.00436
MAPK6 mitogen-activated protein kinase 6 2.00087

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -5.34639
HOXA5 homeobox A5 -4.81207
HAT1 histone acetyltransferase 1 -4.65076
HMG20B high mobility group 20B -4.60076
COTL1 coactosin-like F-actin binding protein 1 -4.50838
PCNA proliferating cell nuclear antigen -4.39557
TNIP1 TNFAIP3 interacting protein 1 -4.04923
CHIC2 cysteine-rich hydrophobic domain 2 -3.80999
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.23488
BID BH3 interacting domain death agonist -3.21766
RPS5 ribosomal protein S5 -3.05815
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.01475
CENPX centromere protein X -2.93129
AURKA aurora kinase A -2.92802
NRIP1 nuclear receptor interacting protein 1 -2.84597
TKT transketolase -2.75101
TCEA2 transcription elongation factor A (SII), 2 -2.72191
CETN2 centrin, EF-hand protein, 2 -2.68256
DEPP1 DEPP autophagy regulator 1 -2.59762
CSRP1 cysteine and glycine-rich protein 1 -2.48823
S100A8 S100 calcium binding protein A8 -2.48371
DND1 DND microRNA-mediated repression inhibitor 1 -2.45667
BCAP31 B-cell receptor-associated protein 31 -2.42124
FAM193B family with sequence similarity 193, member B -2.39872
TSC22D3 TSC22 domain family, member 3 -2.3686
PANK4 pantothenate kinase 4 -2.34478
MSMO1 methylsterol monooxygenase 1 -2.32094
CIRSR corepressor of RBPJ and splicing regulator -2.3106
CLIC2 chloride intracellular channel 2 -2.23905
DCXR dicarbonyl/L-xylulose reductase -2.2179
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -2.2114
BHMT2 betaine--homocysteine S-methyltransferase 2 -2.20933
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.19958
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -2.18422
BFAR bifunctional apoptosis regulator -2.18203
GPX3 glutathione peroxidase 3 -2.13699
CENPI centromere protein I -2.13573
GPS1 G protein pathway suppressor 1 -2.13256
PXDC1 PX domain containing 1 -2.12619
E4F1 E4F transcription factor 1 -2.07859
ISYNA1 inositol-3-phosphate synthase 1 -2.07195
MACO1 macoilin 1 -2.06599
HOXB2 homeobox B2 -2.05603
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.0533
HYI hydroxypyruvate isomerase (putative) -2.05102
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.04533
ARMC7 armadillo repeat containing 7 -2.03349
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 -2.03159
TENT4A terminal nucleotidyltransferase 4A -2.02527
HOXA7 homeobox A7 -2.02115
EXOSC10 exosome component 10 -2.00537