CRCGN015_MCF10A.TP53.M_24H:I07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 100.46 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

205 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.82985
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.3325
STK10 serine/threonine kinase 10 5.05835
C2CD2 C2 calcium-dependent domain containing 2 4.6821
SPAG4 sperm associated antigen 4 4.4959
ALDOC aldolase C, fructose-bisphosphate 4.0131
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.83795
KIF5C kinesin family member 5C 3.69583
ITM2C integral membrane protein 2C 3.62495
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.47175
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.32255
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.22645
PNKP polynucleotide kinase 3'-phosphatase 3.13985
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.93345
BACE2 beta-site APP-cleaving enzyme 2 2.9077
ETFB electron-transfer-flavoprotein, beta polypeptide 2.743
HBA1 hemoglobin, alpha 1 2.74132
SEC24C SEC24 family member C 2.71725
CCL20 chemokine (C-C motif) ligand 20 2.6944
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.56467
PPARG peroxisome proliferator-activated receptor gamma 2.5463
SDC4 syndecan 4 2.49965
ARID5B AT rich interactive domain 5B (MRF1-like) 2.4772
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.477
MELK maternal embryonic leucine zipper kinase 2.47205
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.4447
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.42275
B4GAT1 beta-1,4-glucuronyltransferase 1 2.403
CCNA1 cyclin A1 2.392
TMED9 transmembrane emp24 protein transport domain containing 9 2.34495
CXCL3 chemokine (C-X-C motif) ligand 3 2.34195
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.33685
CDC25B cell division cycle 25B 2.3355
BLMH bleomycin hydrolase 2.31825
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.2923
UBA1 ubiquitin-like modifier activating enzyme 1 2.2738
TOMM34 translocase of outer mitochondrial membrane 34 2.2723
PLTP phospholipid transfer protein 2.26425
GPKOW G patch domain and KOW motifs 2.24835
NLRP4 NLR family, pyrin domain containing 4 2.2296
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.22535
HDLBP high density lipoprotein binding protein 2.21475
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.19305
HBB hemoglobin, beta 2.17853
CADM1 cell adhesion molecule 1 2.1681
TNIP1 TNFAIP3 interacting protein 1 2.16525
WDR13 WD repeat domain 13 2.14175
PORCN porcupine homolog (Drosophila) 2.1338
LARS1 leucyl-tRNA synthetase 1 2.13245
PRAF2 PRA1 domain family, member 2 2.12815
NBAS neuroblastoma amplified sequence 2.12295
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.1151
NUP43 nucleoporin 43kDa 2.11265
PCCB propionyl CoA carboxylase, beta polypeptide 2.08485
LOC107986346 mitochondrial import receptor subunit TOM7 homolog 2.08225
ECH1 enoyl CoA hydratase 1, peroxisomal 2.07895
MTMR11 myotubularin related protein 11 2.06925
DYNLT3 dynein, light chain, Tctex-type 3 2.06135
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.05665
RETREG3 reticulophagy regulator family member 3 2.05035
DOCK6 dedicator of cytokinesis 6 2.04307
VAT1 vesicle amine transport 1 2.0341
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.03145
GALE UDP-galactose-4-epimerase 2.028
ANXA6 annexin A6 2.02355
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.0129
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.0091
COL4A2 collagen, type IV, alpha 2 2.00025

decreased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A -5.57
ENOPH1 enolase-phosphatase 1 -5.3945
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.9726
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.69375
PCNA proliferating cell nuclear antigen -4.66275
NUP85 nucleoporin 85kDa -4.3997
DERA deoxyribose-phosphate aldolase (putative) -4.2331
KIF20A kinesin family member 20A -4.0401
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.89208
MRPS7 mitochondrial ribosomal protein S7 -3.842
KIF14 kinesin family member 14 -3.76555
TOR1A torsin family 1, member A (torsin A) -3.62727
ZDHHC6 zinc finger, DHHC-type containing 6 -3.33555
MRPL58 mitochondrial ribosomal protein L58 -3.14295
SAP30BP SAP30 binding protein -3.0225
SUMO4 small ubiquitin-like modifier 4 -2.9659
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.90865
PRR15L proline rich 15-like -2.8592
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.7613
ADRB2 adrenoceptor beta 2, surface -2.74365
ATF5 activating transcription factor 5 -2.742
HSPA1B heat shock 70kDa protein 1B -2.73798
MCM10 minichromosome maintenance complex component 10 -2.6964
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.68845
ARMC7 armadillo repeat containing 7 -2.67775
TLK2 tousled-like kinase 2 -2.66838
SMCO4 single-pass membrane protein with coiled-coil domains 4 -2.6631
ZNF124 zinc finger protein 124 -2.66055
MKKS McKusick-Kaufman syndrome -2.654
TMEM230 transmembrane protein 230 -2.64805
PANK2 pantothenate kinase 2 -2.6461
FAIM Fas apoptotic inhibitory molecule -2.61655
SPRING1 SREBF pathway regulator in golgi 1 -2.60915
CCDC86 coiled-coil domain containing 86 -2.59425
NOL11 nucleolar protein 11 -2.56725
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.55925
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.55355
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.52895
MCMBP minichromosome maintenance complex binding protein -2.51025
NELL1 NEL-like 1 (chicken) -2.50775
RAPSN receptor-associated protein of the synapse -2.47955
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.4739
TIGAR TP53 induced glycolysis regulatory phosphatase -2.45695
CENPX centromere protein X -2.44885
EIF5 eukaryotic translation initiation factor 5 -2.43725
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.43505
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.43295
GRHL2 grainyhead-like 2 (Drosophila) -2.41655
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.40482
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.40015
MXRA8 matrix-remodelling associated 8 -2.3924
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.3908
NLRP2B NLR family pyrin domain containing 2B -2.38175
DUSP14 dual specificity phosphatase 14 -2.37965
TOR1B torsin family 1, member B (torsin B) -2.3782
GTF2A2 general transcription factor IIA, 2, 12kDa -2.37725
NOP56 NOP56 ribonucleoprotein -2.3743
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.3342
MRPL44 mitochondrial ribosomal protein L44 -2.33295
CORO1A coronin, actin binding protein, 1A -2.3214
MYL11 myosin light chain 11 -2.31605
FBXO21 F-box protein 21 -2.31122
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.3109
ERCC6L excision repair cross-complementation group 6-like -2.305
TMEM94 transmembrane protein 94 -2.3013
C1QBP complement component 1, q subcomponent binding protein -2.29757
SDAD1 SDA1 domain containing 1 -2.28895
ALOX5AP arachidonate 5-lipoxygenase-activating protein -2.2839
MTA2 metastasis associated 1 family, member 2 -2.2831
AVPR1B arginine vasopressin receptor 1B -2.27445
RMI1 RecQ mediated genome instability 1 -2.26995
FRK fyn-related Src family tyrosine kinase -2.26295
LUZP2 leucine zipper protein 2 -2.2599
HCRT hypocretin (orexin) neuropeptide precursor -2.25745
THUMPD2 THUMP domain containing 2 -2.2534
CHIA chitinase, acidic -2.2503
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.23872
MCM6 minichromosome maintenance complex component 6 -2.2383
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.23575
KCTD2 potassium channel tetramerization domain containing 2 -2.2349
FNBP1L formin binding protein 1-like -2.23335
TXNL4B thioredoxin-like 4B -2.2279
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 -2.22435
PUS7 pseudouridylate synthase 7 (putative) -2.2214
TDG thymine-DNA glycosylase -2.21855
PEX13 peroxisomal biogenesis factor 13 -2.21305
STEAP4 STEAP family member 4 -2.2002
MYF5 myogenic factor 5 -2.19365
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.1873
ADGRG3 adhesion G protein-coupled receptor G3 -2.1753
ADI1 acireductone dioxygenase 1 -2.17445
NSUN3 NOP2/Sun domain family, member 3 -2.167
NOP2 NOP2 nucleolar protein -2.16625
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.1645
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -2.1605
SLC38A12 solute carrier family 38 member 12 -2.159
TLR1 toll-like receptor 1 -2.15835
CASKIN2 CASK interacting protein 2 -2.15573
MUC6 mucin 6, oligomeric mucus/gel-forming -2.1514
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 -2.1481
FUBP3 far upstream element (FUSE) binding protein 3 -2.13695
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.11725
ZNF195 zinc finger protein 195 -2.11655
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.11215
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.1107
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.10945
NRSN2 neurensin 2 -2.0981
IL21 interleukin 21 -2.0937
PPP4R3B protein phosphatase 4 regulatory subunit 3B -2.0928
MTNAP1 mitochondrial nucleoid associated protein 1 -2.08475
FN3KRP fructosamine 3 kinase related protein -2.07925
ZFY zinc finger protein, Y-linked -2.0753
MYNN myoneurin -2.0682
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) -2.06703
FEV FEV (ETS oncogene family) -2.0632
PRSS53 protease, serine, 53 -2.0584
PCDHGA1 protocadherin gamma subfamily A, 1 -2.0583
TXNDC9 thioredoxin domain containing 9 -2.05183
SPPL2A signal peptide peptidase like 2A -2.0517
AIG1 androgen-induced 1 -2.04995
PCDHGA3 protocadherin gamma subfamily A, 3 -2.0489
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.04735
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.04715
GRB2 growth factor receptor-bound protein 2 -2.04125
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.0369
CCKBR cholecystokinin B receptor -2.0368
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -2.03135
MYF6 myogenic factor 6 (herculin) -2.03005
SEPHS1 selenophosphate synthetase 1 -2.02523
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -2.02235
ZNF35 zinc finger protein 35 -2.02155
ELAC2 elaC ribonuclease Z 2 -2.02045
SMIM10L1 small integral membrane protein 10 like 1 -2.0128
CST4 cystatin S -2.0116
PLPBP pyridoxal phosphate binding protein -2.01067
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -2.00945
PNO1 partner of NOB1 homolog (S. cerevisiae) -2.0066