CRCGN015_MCF10A.TP53.M_24H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 33.49 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

44 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 5.43005
E2F2 E2F transcription factor 2 5.2509
SSBP2 single-stranded DNA binding protein 2 5.08285
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.0782
NRIP1 nuclear receptor interacting protein 1 4.11123
ACAA1 acetyl-CoA acyltransferase 1 3.8337
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.6726
EPN2 epsin 2 2.9215
PECR peroxisomal trans-2-enoyl-CoA reductase 2.92085
SATB1 SATB homeobox 1 2.8844
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.7979
AAMDC adipogenesis associated, Mth938 domain containing 2.70922
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.68335
PKN1 protein kinase N1 2.58917
RSF1 remodeling and spacing factor 1 2.4311
AKAP10 A kinase (PRKA) anchor protein 10 2.3304
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.2095
HBA1 hemoglobin, alpha 1 2.16662
OXCT1 3-oxoacid CoA transferase 1 2.1517
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.1334
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.08575
RHOC ras homolog family member C 2.07185

decreased expression

Symbol Name Standardized Value
TES testin LIM domain protein -5.5335
CHIC2 cysteine-rich hydrophobic domain 2 -5.51855
CDK4 cyclin-dependent kinase 4 -4.76575
CYCS cytochrome c, somatic -4.7366
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.87883
DSG2 desmoglein 2 -3.63625
METTL1 methyltransferase like 1 -3.3762
SGK1 serum/glucocorticoid regulated kinase 1 -3.27555
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.9096
TSPAN31 tetraspanin 31 -2.5456
HLA-DMB major histocompatibility complex, class II, DM beta -2.41355
CD83 CD83 molecule -2.3853
HCCS holocytochrome c synthase -2.3351
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -2.3184
TMEM248 transmembrane protein 248 -2.2267
KRT14 keratin 14, type I -2.185
PALM2AKAP2 PALM2 and AKAP2 fusion -2.13565
TSFM Ts translation elongation factor, mitochondrial -2.1333
USP36 ubiquitin specific peptidase 36 -2.13095
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -2.097
CISD1 CDGSH iron sulfur domain 1 -2.08045
CCDC86 coiled-coil domain containing 86 -2.01915