CRCGN015_MCF10A.TP53.M_24H:I10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aroclor 1260 95.81 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

194 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 7.66415
TOMM34 translocase of outer mitochondrial membrane 34 6.3756
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.17675
RAB11FIP2 RAB11 family interacting protein 2 (class I) 4.9691
CXCL2 chemokine (C-X-C motif) ligand 2 4.7261
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.6282
NRIP1 nuclear receptor interacting protein 1 4.06045
TIAM1 T-cell lymphoma invasion and metastasis 1 3.80708
ACAA1 acetyl-CoA acyltransferase 1 3.61425
CCL2 chemokine (C-C motif) ligand 2 3.4359
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.3649
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.15012
PDLIM1 PDZ and LIM domain 1 3.12315
TCEA2 transcription elongation factor A (SII), 2 3.0885
CERK ceramide kinase 3.0835
CREG1 cellular repressor of E1A-stimulated genes 1 2.80915
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 2.80428
MGST2 microsomal glutathione S-transferase 2 2.77825
CAPN1 calpain 1, (mu/I) large subunit 2.7221
CXCL3 chemokine (C-X-C motif) ligand 3 2.7105
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.64445
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.62975
WIF1 WNT inhibitory factor 1 2.6253
DENND2D DENN/MADD domain containing 2D 2.6237
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.61755
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.5507
SAE1 SUMO1 activating enzyme subunit 1 2.52485
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.4675
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.43365
DSG2 desmoglein 2 2.4187
SCARA3 scavenger receptor class A, member 3 2.38765
TMEM50A transmembrane protein 50A 2.33825
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.3217
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.3016
SLC35F2 solute carrier family 35, member F2 2.2893
SLC35H1 solute carrier family 35 member H1 2.27885
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.26805
BATF basic leucine zipper transcription factor, ATF-like 2.2533
HBB hemoglobin, beta 2.25195
UBXN2B UBX domain protein 2B 2.24305
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.23728
HOXA7 homeobox A7 2.2301
TPX2 TPX2, microtubule-associated 2.2127
HSPB1 heat shock 27kDa protein 1 2.2028
COPS5 COP9 signalosome subunit 5 2.1913
HOXA4 homeobox A4 2.17315
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.17065
VAT1 vesicle amine transport 1 2.15375
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.129
DHRS3 dehydrogenase/reductase (SDR family) member 3 2.1073
TSKU tsukushi, small leucine rich proteoglycan 2.09315
IGFBP6 insulin-like growth factor binding protein 6 2.0812
AGR2 anterior gradient 2 2.0798
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 2.0742
FUCA1 fucosidase, alpha-L- 1, tissue 2.063
KCTD9 potassium channel tetramerization domain containing 9 2.04905
AKAP12 A kinase (PRKA) anchor protein 12 2.03665
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.03635
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 2.029
BTN3A2 butyrophilin, subfamily 3, member A2 2.02825
HLTF helicase-like transcription factor 2.0029

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -5.2302
WASHC4 WASH complex subunit 4 -5.1256
TXNDC9 thioredoxin domain containing 9 -5.03438
HMG20B high mobility group 20B -4.97905
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.93705
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -4.0094
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.61372
KRT14 keratin 14, type I -3.4979
EXT1 exostosin glycosyltransferase 1 -2.95713
MTERF3 mitochondrial transcription termination factor 3 -2.9365
SYN1 synapsin I -2.89745
MTRF1 mitochondrial translational release factor 1 -2.776
CIDEA cell death-inducing DFFA-like effector a -2.69475
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.6599
KRT9 keratin 9, type I -2.63515
MRPS31 mitochondrial ribosomal protein S31 -2.63307
MFSD12 major facilitator superfamily domain containing 12 -2.63105
GPR22 G protein-coupled receptor 22 -2.57255
HPN hepsin -2.5544
CD79B CD79b molecule, immunoglobulin-associated beta -2.55015
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -2.53295
MPPED1 metallophosphoesterase domain containing 1 -2.53225
H1-1 H1.1 linker histone, cluster member -2.46715
ACTN3 actinin, alpha 3 (gene/pseudogene) -2.45285
ZMYM2 zinc finger, MYM-type 2 -2.44843
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -2.433
KIF13A kinesin family member 13A -2.39015
ZCCHC10 zinc finger, CCHC domain containing 10 -2.36235
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like -2.36035
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -2.3597
MED31 mediator complex subunit 31 -2.3588
MICU2 mitochondrial calcium uptake 2 -2.35635
KPLCE KPRP N-terminal and LCE C-terminal like protein -2.355
CRBN cereblon -2.35275
AIRIM AFG2 interacting ribosome maturation factor -2.33725
CALY calcyon neuron-specific vesicular protein -2.3353
GH1 growth hormone 1 -2.32837
MAPK7 mitogen-activated protein kinase 7 -2.31553
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -2.304
CAPN10 calpain 10 -2.27995
FOXO1 forkhead box O1 -2.27305
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.2628
LSAMP limbic system-associated membrane protein -2.2612
LHX3 LIM homeobox 3 -2.25985
ZNF573 zinc finger protein 573 -2.2598
KRT33A keratin 33A, type I -2.2536
ALOXE3 arachidonate lipoxygenase 3 -2.24668
BPHL biphenyl hydrolase-like (serine hydrolase) -2.2433
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.24095
NR5A1 nuclear receptor subfamily 5, group A, member 1 -2.23925
WHR1 winged helix repair factor 1 -2.2349
DNASE1L2 deoxyribonuclease I-like 2 -2.22955
COQ8B coenzyme Q8B -2.2268
SYT13 synaptotagmin XIII -2.21825
OSBPL8 oxysterol binding protein-like 8 -2.21747
LIN7B lin-7 homolog B (C. elegans) -2.21625
ARMCX1 armadillo repeat containing, X-linked 1 -2.2128
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -2.2026
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -2.1861
KRT34 keratin 34, type I -2.1852
NLK nemo-like kinase -2.18065
PDCL3 phosducin-like 3 -2.18055
MTMR10 myotubularin related protein 10 -2.1769
GML glycosylphosphatidylinositol anchored molecule like -2.1736
SPRYD7 SPRY domain containing 7 -2.17235
CDSN corneodesmosin -2.16875
AMH anti-Mullerian hormone -2.16645
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 -2.1613
PAEP progestagen-associated endometrial protein -2.156
ALG11 ALG11, alpha-1,2-mannosyltransferase -2.1545
GPALPP1 GPALPP motifs containing 1 -2.1522
PHKG1 phosphorylase kinase, gamma 1 (muscle) -2.14435
HBD hemoglobin, delta -2.1414
KDM3A lysine (K)-specific demethylase 3A -2.14115
ETV3 ets variant 3 -2.1408
WBP4 WW domain binding protein 4 -2.138
COPE coatomer protein complex, subunit epsilon -2.13365
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.13235
TDRD1 tudor domain containing 1 -2.1317
FGF16 fibroblast growth factor 16 -2.13025
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 -2.1242
AHDC1 AT hook, DNA binding motif, containing 1 -2.11975
PMCH pro-melanin-concentrating hormone -2.108
TUBA4A tubulin, alpha 4a -2.1069
SAPCD1 suppressor APC domain containing 1 -2.10577
IMPACT impact RWD domain protein -2.1038
IL36R interleukin 36 receptor -2.1035
MYBPC2 myosin binding protein C, fast type -2.1027
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 -2.09705
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -2.09665
MYNN myoneurin -2.0952
MPC2 mitochondrial pyruvate carrier 2 -2.0923
BET1 Bet1 golgi vesicular membrane trafficking protein -2.09
DUSP14 dual specificity phosphatase 14 -2.08535
RFTN1 raftlin, lipid raft linker 1 -2.08225
RNF25 ring finger protein 25 -2.08175
ZNF132 zinc finger protein 132 -2.0747
STK38 serine/threonine kinase 38 -2.0731
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.0725
DOC2A double C2-like domains, alpha -2.0669
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 -2.06605
FLG filaggrin -2.0632
MRPS18C mitochondrial ribosomal protein S18C -2.0622
GRPR gastrin-releasing peptide receptor -2.05945
BLK BLK proto-oncogene, Src family tyrosine kinase -2.05015
ZNF514 zinc finger protein 514 -2.04935
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -2.04885
CRHBP corticotropin releasing hormone binding protein -2.0482
LDAF1 lipid droplet assembly factor 1 -2.0473
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -2.04645
SCN4A sodium channel, voltage gated, type IV alpha subunit -2.0449
KCNK12 potassium channel, two pore domain subfamily K, member 12 -2.04085
DMWD dystrophia myotonica, WD repeat containing -2.03885
RALYL RALY RNA binding protein-like -2.0388
ERG v-ets avian erythroblastosis virus E26 oncogene homolog -2.0382
HOOK3 hook microtubule-tethering protein 3 -2.0371
NOPCHAP1 NOP protein chaperone 1 -2.03595
STAB2 stabilin 2 -2.03375
NPPB natriuretic peptide B -2.0298
CEMP1 cementum protein 1 -2.02945
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -2.02852
SPMAP2 sperm microtubule associated protein 2 -2.02465
MYOZ3 myozenin 3 -2.02295
DRD5 dopamine receptor D5 -2.0194
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 -2.01835
POU3F3 POU class 3 homeobox 3 -2.0178
KRT16 keratin 16, type I -2.0173
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.01515
TMEM53 transmembrane protein 53 -2.0151
CRX cone-rod homeobox -2.01485
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.01095
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -2.00912
EMC10 ER membrane protein complex subunit 10 -2.00485