CRCGN015_MCF10A.TP53.M_24H:I14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 33.93 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 4.48983
TBX2 T-box 2 3.75193
SYNE2 spectrin repeat containing, nuclear envelope 2 3.5576
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.5429
CCNF cyclin F 2.5711
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.3923
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.3823
PDLIM1 PDZ and LIM domain 1 2.31245
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.29975
ACBD3 acyl-CoA binding domain containing 3 2.2863
DPH2 DPH2 homolog (S. cerevisiae) 2.2222
IRF6 interferon regulatory factor 6 2.21405
CLCA2 chloride channel accessory 2 2.16341
ESRP1 epithelial splicing regulatory protein 1 2.10975

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -5.22255
GRWD1 glutamate-rich WD repeat containing 1 -4.6142
LYPLA1 lysophospholipase I -4.55492
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.45015
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.0674
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.267
CD81 CD81 molecule -3.19215
SEC61G Sec61 gamma subunit -2.9144
ATP5F1E ATP synthase F1 subunit epsilon -2.7855
DPY19L1 dpy-19-like 1 (C. elegans) -2.4299
GGCT gamma-glutamylcyclotransferase -2.406
LYRM4 LYR motif containing 4 -2.36885
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.29262
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.2747
AVL9 AVL9 homolog (S. cerevisiase) -2.21312
ZNF432 zinc finger protein 432 -2.19115
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.16875
CDH22 cadherin 22, type 2 -2.1613
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.16115
NT5DC2 5'-nucleotidase domain containing 2 -2.14015
SNRPE small nuclear ribonucleoprotein polypeptide E -2.1197
RGN regucalcin -2.11395
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.08335
TMEM258 transmembrane protein 258 -2.0712
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -2.06817
ZNF358 zinc finger protein 358 -2.0451
PIH1D1 PIH1 domain containing 1 -2.0091