CRCGN015_MCF10A.TP53.M_24H:I16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc yellow 4 99.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

108 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 6.13162
LAGE3 L antigen family, member 3 6.12975
C2CD2 C2 calcium-dependent domain containing 2 5.19
KDM5D lysine (K)-specific demethylase 5D 5.0098
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 4.97115
HBB hemoglobin, beta 4.94382
SPAG4 sperm associated antigen 4 4.8842
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 4.24127
USP9Y ubiquitin specific peptidase 9, Y-linked 3.94535
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.8888
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.78487
RSF1 remodeling and spacing factor 1 3.3304
NLGN4Y neuroligin 4, Y-linked 3.259
ZFY zinc finger protein, Y-linked 3.05405
CNRIP1 cannabinoid receptor interacting protein 1 3.04935
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 3.0486
MFSD6 major facilitator superfamily domain containing 6 2.8453
F8A2 coagulation factor VIII-associated 2 2.79435
SLC10A3 solute carrier family 10, member 3 2.68635
THAP12 THAP domain containing 12 2.67795
SATB1 SATB homeobox 1 2.61885
PKN1 protein kinase N1 2.61878
FAM50A family with sequence similarity 50, member A 2.4909
APTX aprataxin 2.38077
AAMDC adipogenesis associated, Mth938 domain containing 2.36262
VBP1 von Hippel-Lindau binding protein 1 2.3352
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.32707
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.324
F8 coagulation factor VIII, procoagulant component 2.3142
CAPN5 calpain 5 2.2744
IRAK1 interleukin-1 receptor-associated kinase 1 2.1899
CADPS2 Ca++-dependent secretion activator 2 2.1563
NUP155 nucleoporin 155kDa 2.14785
WDR83OS WD repeat domain 83 opposite strand 2.11795
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 2.10355
WNT5A wingless-type MMTV integration site family, member 5A 2.08682
VAMP7 vesicle-associated membrane protein 7 2.07945
GPC4 glypican 4 2.05848
NPTX1 neuronal pentraxin I 2.04505
TUSC3 tumor suppressor candidate 3 2.034
PALB2 partner and localizer of BRCA2 2.01915
FAM3A family with sequence similarity 3, member A 2.0177
TNIP3 TNFAIP3 interacting protein 3 2.00745

decreased expression

Symbol Name Standardized Value
KDM5C lysine (K)-specific demethylase 5C -5.0364
OXA1L oxidase (cytochrome c) assembly 1-like -4.70975
CCNB1 cyclin B1 -4.66835
CYCS cytochrome c, somatic -4.66275
WASHC4 WASH complex subunit 4 -4.59235
TRAPPC3 trafficking protein particle complex 3 -4.19807
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -3.69217
PUDP pseudouridine 5'-phosphatase -3.6319
SMC1A structural maintenance of chromosomes 1A -3.34192
KDM6A lysine (K)-specific demethylase 6A -3.26832
GRWD1 glutamate-rich WD repeat containing 1 -2.90545
MTERF3 mitochondrial transcription termination factor 3 -2.867
MRPS15 mitochondrial ribosomal protein S15 -2.6545
CEND1 cell cycle exit and neuronal differentiation 1 -2.64125
ARMC7 armadillo repeat containing 7 -2.5451
COL5A1 collagen, type V, alpha 1 -2.5421
CLDN9 claudin 9 -2.5378
GPR162 G protein-coupled receptor 162 -2.51515
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.4549
THBS1 thrombospondin 1 -2.45237
RCN3 reticulocalbin 3, EF-hand calcium binding domain -2.4334
CD40LG CD40 ligand -2.41135
NR0B2 nuclear receptor subfamily 0, group B, member 2 -2.4075
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.40355
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.39895
OSGIN1 oxidative stress induced growth inhibitor 1 -2.3903
ZFHX4 zinc finger homeobox 4 -2.38005
DNAH3 dynein, axonemal, heavy chain 3 -2.36245
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.3593
NPPA natriuretic peptide A -2.33625
CIC capicua transcriptional repressor -2.31525
SLC35F6 solute carrier family 35, member F6 -2.304
BAAT bile acid CoA:amino acid N-acyltransferase -2.28555
RAP1A RAP1A, member of RAS oncogene family -2.2475
HMX1 H6 family homeobox 1 -2.23925
FGL1 fibrinogen-like 1 -2.23505
USP9X ubiquitin specific peptidase 9, X-linked -2.23185
SIGLEC15 sialic acid binding Ig-like lectin 15 -2.2306
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.21648
OXCT2 3-oxoacid CoA transferase 2 -2.20865
NARS1 asparaginyl-tRNA synthetase 1 -2.20745
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.20005
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.1916
TPPP tubulin polymerization promoting protein -2.18685
GSTM5 glutathione S-transferase mu 5 -2.18095
COL5A3 collagen, type V, alpha 3 -2.14013
WDR62 WD repeat domain 62 -2.1376
CERT1 ceramide transporter 1 -2.13705
MYOG myogenin (myogenic factor 4) -2.13505
ATAD3A ATPase family, AAA domain containing 3A -2.12735
C8B complement component 8, beta polypeptide -2.11655
UBA1 ubiquitin-like modifier activating enzyme 1 -2.1004
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -2.0898
POU2F2 POU class 2 homeobox 2 -2.07942
SH3BP1 SH3-domain binding protein 1 -2.0738
DUSP14 dual specificity phosphatase 14 -2.0691
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.0685
GAST gastrin -2.0607
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.05338
SDK2 sidekick cell adhesion molecule 2 -2.04185
AMN amnion associated transmembrane protein -2.03225
MISP mitotic spindle positioning -2.02645
COCH cochlin -2.02375
CPTP ceramide-1-phosphate transfer protein -2.00665
GLI1 GLI family zinc finger 1 -2.0057