CRCGN015_MCF10A.TP53.M_24H:I17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc yellow 4 33.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 5.17803
CCP110 centriolar coiled coil protein 110kDa 4.94455
ADAT1 adenosine deaminase, tRNA-specific 1 3.4941
ACAA1 acetyl-CoA acyltransferase 1 3.48005
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 3.3599
HBA1 hemoglobin, alpha 1 2.8195
TEX2 testis expressed 2 2.66765
FCHO1 FCH domain only 1 2.47635
WDR76 WD repeat domain 76 2.36725
FBXL12 F-box and leucine-rich repeat protein 12 2.34115
MCUR1 mitochondrial calcium uniporter regulator 1 2.24615
CPEB1 cytoplasmic polyadenylation element binding protein 1 2.1433
LIPC lipase, hepatic 2.1202
UNG uracil-DNA glycosylase 2.0713
SRBD1 S1 RNA binding domain 1 2.0533
MAN2A1 mannosidase, alpha, class 2A, member 1 2.0502
ZNF281 zinc finger protein 281 2.0339
EXOC2 exocyst complex component 2 2.00215

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.60695
ADI1 acireductone dioxygenase 1 -5.55045
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.86153
COG7 component of oligomeric golgi complex 7 -4.81345
SPAG7 sperm associated antigen 7 -3.9693
UBFD1 ubiquitin family domain containing 1 -3.48335
HSPA1A heat shock 70kDa protein 1A -3.1024
DCTN5 dynactin 5 (p25) -3.04805
CPNE3 copine III -2.96953
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -2.73905
ARHGAP17 Rho GTPase activating protein 17 -2.68105
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.6587
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa -2.56165
ZNF629 zinc finger protein 629 -2.5546
KEAP1 kelch-like ECH-associated protein 1 -2.4657
TIMP1 TIMP metallopeptidase inhibitor 1 -2.40345
ETV6 ets variant 6 -2.3692
GPN1 GPN-loop GTPase 1 -2.35685
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.3399
ASXL2 additional sex combs like transcriptional regulator 2 -2.3087
KRT14 keratin 14, type I -2.2936
IFT46 intraflagellar transport 46 -2.24035
CNOT1 CCR4-NOT transcription complex, subunit 1 -2.22172
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.2154
ZPR1 ZPR1 zinc finger -2.20917
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.19465
R3HDM2 R3H domain containing 2 -2.16795
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.1649
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.16235
UQCRC2 ubiquinol-cytochrome c reductase core protein II -2.15462
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 -2.1294
TNS2 tensin 2 -2.1194
FOXC1 forkhead box C1 -2.1042
ZNF652 zinc finger protein 652 -2.0933
SLC35H1 solute carrier family 35 member H1 -2.0841
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.0446
CAPN2 calpain 2, (m/II) large subunit -2.04142
INSIG1 insulin induced gene 1 -2.04078