CRCGN015_MCF10A.TP53.M_24H:I18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc yellow 4 11.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GATA3 GATA binding protein 3 8.17558
SNAP25 synaptosomal-associated protein, 25kDa 5.57265
ADAM10 ADAM metallopeptidase domain 10 4.93537
HBA1 hemoglobin, alpha 1 4.13332
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.99565
SYT1 synaptotagmin I 3.58752
SCG3 secretogranin III 2.845
TMEM50B transmembrane protein 50B 2.8178
KDM5D lysine (K)-specific demethylase 5D 2.8052
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.5973
USP9Y ubiquitin specific peptidase 9, Y-linked 2.57407
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.56567
NOSIP nitric oxide synthase interacting protein 2.5345
CARTPT CART prepropeptide 2.5191
ELP4 elongator acetyltransferase complex subunit 4 2.47435
MINDY2 MINDY lysine 48 deubiquitinase 2 2.46068
SYN1 synapsin I 2.43285
BAG1 BCL2-associated athanogene 2.36877
NSG2 neuronal vesicle trafficking associated 2 2.36495
STMN2 stathmin 2 2.35698
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.33925
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.32805
BEX2 brain expressed X-linked 2 2.29235
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.29055
FLRT3 fibronectin leucine rich transmembrane protein 3 2.2862
INA internexin neuronal intermediate filament protein, alpha 2.28015
MFAP4 microfibrillar-associated protein 4 2.18745
SPC25 SPC25, NDC80 kinetochore complex component 2.1794
CRIPT cysteine-rich PDZ-binding protein 2.17265
SV2B synaptic vesicle glycoprotein 2B 2.168
EAPP E2F-associated phosphoprotein 2.1541
DCTN3 dynactin 3 (p22) 2.15275
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 2.1523
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.13895
CKMT1A creatine kinase, mitochondrial 1A 2.1176
RSF1 remodeling and spacing factor 1 2.1136
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.1068
SCG2 secretogranin II 2.10415
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 2.0997
NAGK N-acetylglucosamine kinase 2.08485
XPA xeroderma pigmentosum, complementation group A 2.0829
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.0763
ZNF32 zinc finger protein 32 2.07515
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.05655
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 2.05168
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.04925
PLSCR3 phospholipid scramblase 3 2.04365
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.0268
DNAAF2 dynein, axonemal, assembly factor 2 2.0259
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.00695
PARP6 poly (ADP-ribose) polymerase family, member 6 2.00315

decreased expression

Symbol Name Standardized Value
PUF60 poly-U binding splicing factor 60KDa -5.06595
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.85165
CD81 CD81 molecule -4.33475
KDM5C lysine (K)-specific demethylase 5C -3.74445
UBA1 ubiquitin-like modifier activating enzyme 1 -3.67375
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.49793
SMC1A structural maintenance of chromosomes 1A -3.1442
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.13165
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.98681
TLK2 tousled-like kinase 2 -2.53717
MSN moesin -2.49935
SCRIB scribbled planar cell polarity protein -2.4359
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.41335
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.35855
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.35737
USP9X ubiquitin specific peptidase 9, X-linked -2.32617
CABIN1 calcineurin binding protein 1 -2.28603
BOP1 block of proliferation 1 -2.2372
AKAP17A A kinase (PRKA) anchor protein 17A -2.21535
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.21195
GSDMD gasdermin D -2.2039
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.1232
WWC2 WW and C2 domain containing 2 -2.08375
RESF1 retroelement silencing factor 1 -2.07525
EREG epiregulin -2.06675
FOXJ1 forkhead box J1 -2.06145