CRCGN015_MCF10A.TP53.M_24H:I19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiotepa 98.88 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 4.84265
CCDC85B coiled-coil domain containing 85B 4.52695
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.51225
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.9104
B4GAT1 beta-1,4-glucuronyltransferase 1 3.43995
TM9SF3 transmembrane 9 superfamily member 3 3.16755
ACLY ATP citrate lyase 2.99777
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.53005
DNM1 dynamin 1 2.1937
TMCC2 transmembrane and coiled-coil domain family 2 2.1802
RAI14 retinoic acid induced 14 2.16895
GRB7 growth factor receptor-bound protein 7 2.16085
REG3A regenerating islet-derived 3 alpha 2.08735
ATP8B4 ATPase, class I, type 8B, member 4 2.07925
TG thyroglobulin 2.0333
LYN LYN proto-oncogene, Src family tyrosine kinase 2.02455
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.0122

decreased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 -6.35355
KRT14 keratin 14, type I -5.52375
CTNND1 catenin (cadherin-associated protein), delta 1 -5.07338
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.9081
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.49123
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.04805
SSR4 signal sequence receptor, delta -3.3639
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.69565
TMX2 thioredoxin-related transmembrane protein 2 -2.64175
GAS2 growth arrest-specific 2 -2.4462
RNF4 ring finger protein 4 -2.4179
NAXD NAD(P)HX dehydratase -2.39165
REXO2 RNA exonuclease 2 -2.30514
SORBS3 sorbin and SH3 domain containing 3 -2.2063
DDIT4 DNA-damage-inducible transcript 4 -2.16665
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -2.1242
PRPF3 pre-mRNA processing factor 3 -2.1057
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.07338
RPS5 ribosomal protein S5 -2.065
CETN2 centrin, EF-hand protein, 2 -2.04105
IRAK1 interleukin-1 receptor-associated kinase 1 -2.02805