CRCGN015_MCF10A.TP53.M_24H:I20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiotepa 32.96 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

20 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.8904
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.47062
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.3702
AGR2 anterior gradient 2 2.9664
CNRIP1 cannabinoid receptor interacting protein 1 2.9452
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.90635
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.71605
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.46595
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.05505
TSKU tsukushi, small leucine rich proteoglycan 2.047
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.03685

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -4.76025
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.8572
TMEM115 transmembrane protein 115 -3.76505
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.6572
IFRD2 interferon-related developmental regulator 2 -3.13072
SGK1 serum/glucocorticoid regulated kinase 1 -2.9806
SNX7 sorting nexin 7 -2.1435
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.0932
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.0485