CRCGN015_MCF10A.TP53.M_24H:I21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiotepa 10.99 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

18 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UGDH UDP-glucose 6-dehydrogenase 4.34225
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.01265
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.79755
MINDY1 MINDY lysine 48 deubiquitinase 1 2.5485
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.47185
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.3842
CERK ceramide kinase 2.3082
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.2922
BLMH bleomycin hydrolase 2.18975
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.16591

decreased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.0708
SMNDC1 survival motor neuron domain containing 1 -4.6835
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -4.44035
HSPA1A heat shock 70kDa protein 1A -2.9846
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.54375
ACAA1 acetyl-CoA acyltransferase 1 -2.32958
CORO1A coronin, actin binding protein, 1A -2.2842
MTERF3 mitochondrial transcription termination factor 3 -2.16005