CRCGN015_MCF10A.TP53.M_24H:I22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 100.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.2491
HBA1 hemoglobin, alpha 1 4.83593
MICALL1 MICAL-like 1 4.11137
HBB hemoglobin, beta 3.99757
NRBF2 nuclear receptor binding factor 2 3.93645
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.7594
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.6162
HACD3 3-hydroxyacyl-CoA dehydratase 3 3.54875
IL1B interleukin 1, beta 3.47263
GPATCH8 G patch domain containing 8 2.98335
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.6109
CCL22 chemokine (C-C motif) ligand 22 2.59745
GSTZ1 glutathione S-transferase zeta 1 2.47425
EPHB2 EPH receptor B2 2.29513
CLDND1 claudin domain containing 1 2.27155
CTBP2 C-terminal binding protein 2 2.2579
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.243
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.236
HMOX1 heme oxygenase 1 2.23295
ZNHIT6 zinc finger, HIT-type containing 6 2.17645
ACTA2 actin, alpha 2, smooth muscle, aorta 2.13
CCR7 chemokine (C-C motif) receptor 7 2.12765
GRB7 growth factor receptor-bound protein 7 2.12
EPB41L3 erythrocyte membrane protein band 4.1-like 3 2.09798
CEP15 centrosomal protein 15 2.0972
DVL3 dishevelled segment polarity protein 3 2.0805
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.0516
PLAU plasminogen activator, urokinase 2.0388
FABP4 fatty acid binding protein 4, adipocyte 2.0329
C5AR1 complement component 5a receptor 1 2.01755
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 2.00735

decreased expression

Symbol Name Standardized Value
PLK1 polo-like kinase 1 -5.92805
COG2 component of oligomeric golgi complex 2 -5.36895
HSPA8 heat shock 70kDa protein 8 -5.00518
TRAPPC3 trafficking protein particle complex 3 -4.3631
CD320 CD320 molecule -3.62715
RBM34 RNA binding motif protein 34 -3.39915
FOS FBJ murine osteosarcoma viral oncogene homolog -3.3563
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -3.22642
GRWD1 glutamate-rich WD repeat containing 1 -3.0413
THAP11 THAP domain containing 11 -3.03565
RPA3 replication protein A3, 14kDa -2.88965
PTPRK protein tyrosine phosphatase, receptor type, K -2.73755
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.7033
TCTA T-cell leukemia translocation altered -2.6422
TBCE tubulin folding cofactor E -2.6261
CERT1 ceramide transporter 1 -2.489
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.44835
ZNF747 zinc finger protein 747 -2.3639
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.317
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.2973
C2CD5 C2 calcium-dependent domain containing 5 -2.2846
GALK1 galactokinase 1 -2.28165
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.26445
RTRAF RNA transcription, translation and transport factor -2.25995
IGFBP7 insulin-like growth factor binding protein 7 -2.24458
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.2117
HAPLN1 hyaluronan and proteoglycan link protein 1 -2.20773
EIF3H eukaryotic translation initiation factor 3, subunit H -2.20265
ATL2 atlastin GTPase 2 -2.1707
BORCS8 BLOC-1 related complex subunit 8 -2.16645
MRPL37 mitochondrial ribosomal protein L37 -2.14745
METTL9 methyltransferase like 9 -2.12835
HOXC11 homeobox C11 -2.10115
ERP29 endoplasmic reticulum protein 29 -2.1003
SNTA1 syntrophin, alpha 1 -2.07635
S100PBP S100P binding protein -2.0539
CDH4 cadherin 4, type 1, R-cadherin (retinal) -2.05102
SPIN2B spindlin family, member 2B -2.0389
TAC4 tachykinin 4 (hemokinin) -2.03395
IRF3 interferon regulatory factor 3 -2.0167
CA9 carbonic anhydrase IX -2.00535
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.0014