CRCGN015_MCF10A.TP53.M_24H:I23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 33.66 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

120 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:I23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.94555
HBA1 hemoglobin, alpha 1 4.76215
VAV3 vav 3 guanine nucleotide exchange factor 4.5516
TIAM1 T-cell lymphoma invasion and metastasis 1 4.16185
CNRIP1 cannabinoid receptor interacting protein 1 3.9471
GATA2 GATA binding protein 2 3.74878
ACAA1 acetyl-CoA acyltransferase 1 3.33838
SNCA synuclein, alpha (non A4 component of amyloid precursor) 3.18689
COQ8A coenzyme Q8A 2.9597
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.8561
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.80005
NFIL3 nuclear factor, interleukin 3 regulated 2.66625
LYZ lysozyme 2.65435
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.6342
SCAND1 SCAN domain containing 1 2.59465
ZNF324 zinc finger protein 324 2.54645
HBB hemoglobin, beta 2.52867
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.4562
EPS8 epidermal growth factor receptor pathway substrate 8 2.4504
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 2.4028
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 2.39538
SATB1 SATB homeobox 1 2.3379
DCXR dicarbonyl/L-xylulose reductase 2.304
STRN4 striatin, calmodulin binding protein 4 2.24935
IGLL1 immunoglobulin lambda-like polypeptide 1 2.22725
REPIN1 replication initiator 1 2.20195
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.18745
DOCK4 dedicator of cytokinesis 4 2.1846
DAPL1 death associated protein-like 1 2.1802
WIF1 WNT inhibitory factor 1 2.18
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.17646
NKRF NFKB repressing factor 2.1569
MPC1 mitochondrial pyruvate carrier 1 2.1557
RAB31 RAB31, member RAS oncogene family 2.14482
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.1136
CPTP ceramide-1-phosphate transfer protein 2.1125
MACROD1 MACRO domain containing 1 2.096
RNF123 ring finger protein 123 2.06165
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.0606
ARHGAP22 Rho GTPase activating protein 22 2.05575
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.05253
RALY RALY heterogeneous nuclear ribonucleoprotein 2.0492
CAPN1 calpain 1, (mu/I) large subunit 2.044
PCDHGA5 protocadherin gamma subfamily A, 5 2.0434
AGR2 anterior gradient 2 2.0309
CENPB centromere protein B, 80kDa 2.02735
RNF144A ring finger protein 144A 2.01595
MON1B MON1 secretory trafficking family member B 2.0092
ZNF318 zinc finger protein 318 2.00318

decreased expression

Symbol Name Standardized Value
FOS FBJ murine osteosarcoma viral oncogene homolog -7.703
TRAPPC3 trafficking protein particle complex 3 -5.019
PGAM4 phosphoglycerate mutase family member 4 -4.66275
HMG20B high mobility group 20B -4.29755
HEATR1 HEAT repeat containing 1 -4.03387
LAP3 leucine aminopeptidase 3 -4.0247
CREB1 cAMP responsive element binding protein 1 -3.77456
RPS5 ribosomal protein S5 -3.4734
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -3.1384
FMOD fibromodulin -3.0591
ANKRD10 ankyrin repeat domain 10 -2.9938
RBM34 RNA binding motif protein 34 -2.85993
TTC1 tetratricopeptide repeat domain 1 -2.84745
MEAF6 MYST/Esa1-associated factor 6 -2.78965
S100PBP S100P binding protein -2.78615
GGPS1 geranylgeranyl diphosphate synthase 1 -2.74802
AIM2 absent in melanoma 2 -2.7418
CNMD chondromodulin -2.636
DCPH1 damage control phosphatase 1 -2.635
TMEM47 transmembrane protein 47 -2.62075
ENO2 enolase 2 (gamma, neuronal) -2.58235
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.5114
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.50355
KRT14 keratin 14, type I -2.46525
OXA1L oxidase (cytochrome c) assembly 1-like -2.46105
MRPS15 mitochondrial ribosomal protein S15 -2.46
CALCB calcitonin-related polypeptide beta -2.4452
TCTN1 tectonic family member 1 -2.4424
CRYZ crystallin, zeta (quinone reductase) -2.4243
ZMPSTE24 zinc metallopeptidase STE24 -2.41275
BMPR1A bone morphogenetic protein receptor, type IA -2.38825
RFC2 replication factor C (activator 1) 2, 40kDa -2.32128
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -2.3054
AGO1 argonaute RISC catalytic component 1 -2.27355
LRRC36 leucine rich repeat containing 36 -2.2545
ABI2 abl-interactor 2 -2.24238
EPHX3 epoxide hydrolase 3 -2.23485
KDM3A lysine (K)-specific demethylase 3A -2.22795
ZMYM4 zinc finger, MYM-type 4 -2.20848
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -2.20745
LAPTM4A lysosomal protein transmembrane 4 alpha -2.20435
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -2.2041
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.20275
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -2.1972
TBCE tubulin folding cofactor E -2.1868
NAGK N-acetylglucosamine kinase -2.17925
AIDA axin interactor, dorsalization associated -2.1614
WDFY3 WD repeat and FYVE domain containing 3 -2.1588
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.14985
ZNF638 zinc finger protein 638 -2.14933
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.14865
CCDC90B coiled-coil domain containing 90B -2.14505
FAT4 FAT atypical cadherin 4 -2.13245
ANXA6 annexin A6 -2.1311
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.12965
RTN4 reticulon 4 -2.12733
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.126
CCSER2 coiled-coil serine-rich protein 2 -2.11005
WAPL WAPL cohesin release factor -2.09595
REEP5 receptor accessory protein 5 -2.09247
RPS27A ribosomal protein S27a -2.0676
ANXA2 annexin A2 -2.06572
ZNF143 zinc finger protein 143 -2.0635
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.05145
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.0476
TNNC1 troponin C type 1 (slow) -2.0471
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.0459
ENO1 enolase 1, (alpha) -2.01968
ECD ecdysoneless homolog (Drosophila) -2.01915
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -2.00645
PIH1D1 PIH1 domain containing 1 -2.00205