CRCGN015_MCF10A.TP53.M_24H:J02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazobenzene 33.99 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 6.4967
SPAG4 sperm associated antigen 4 5.4687
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.79251
CNPY3 canopy FGF signaling regulator 3 4.40133
PDLIM1 PDZ and LIM domain 1 4.20605
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 4.11314
CNRIP1 cannabinoid receptor interacting protein 1 3.80235
CARMIL1 capping protein regulator and myosin 1 linker 1 3.7198
LYN LYN proto-oncogene, Src family tyrosine kinase 3.1673
HLA-DRA major histocompatibility complex, class II, DR alpha 3.16322
NVL nuclear VCP-like 3.02449
GPATCH8 G patch domain containing 8 2.96966
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.717
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.64654
IQGAP1 IQ motif containing GTPase activating protein 1 2.6064
GADD45A growth arrest and DNA-damage-inducible, alpha 2.48309
CCNA1 cyclin A1 2.47288
TOMM34 translocase of outer mitochondrial membrane 34 2.44629
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 2.33949
MDM4 MDM4, p53 regulator 2.3287
RNF103-CHMP3 RNF103-CHMP3 readthrough 2.27585
PTPRK protein tyrosine phosphatase, receptor type, K 2.27553
CNGA3 cyclic nucleotide gated channel alpha 3 2.22683
FSD1 fibronectin type III and SPRY domain containing 1 2.19937
SYTL3 synaptotagmin-like 3 2.16881
CHP2 calcineurin-like EF-hand protein 2 2.16361
NUAK1 NUAK family, SNF1-like kinase, 1 2.13795
AURKB aurora kinase B 2.11542
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.10617
TMEM131 transmembrane protein 131 2.09193
MTA2 metastasis associated 1 family, member 2 2.07243
CCDC85B coiled-coil domain containing 85B 2.07097
TGFB3 transforming growth factor, beta 3 2.06858
TSHB thyroid stimulating hormone, beta 2.05784
TMEM209 transmembrane protein 209 2.04977
OVGP1 oviductal glycoprotein 1, 120kDa 2.04952
COMP cartilage oligomeric matrix protein 2.02804
ST7L suppression of tumorigenicity 7 like 2.0195
EFCC1 EF-hand and coiled-coil domain containing 1 2.01748

decreased expression

Symbol Name Standardized Value
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -5.05966
CHIC2 cysteine-rich hydrophobic domain 2 -5.02881
CD81 CD81 molecule -4.86143
DSG2 desmoglein 2 -4.58724
SCYL3 SCY1-like 3 (S. cerevisiae) -4.44391
HMG20B high mobility group 20B -4.2834
RNF167 ring finger protein 167 -4.25175
TSPAN4 tetraspanin 4 -4.18016
SGK1 serum/glucocorticoid regulated kinase 1 -3.67303
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.49137
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.09989
HYAL2 hyaluronoglucosaminidase 2 -2.74415
ACAA1 acetyl-CoA acyltransferase 1 -2.44717
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.37897
IFRD2 interferon-related developmental regulator 2 -2.32702
CETN2 centrin, EF-hand protein, 2 -2.2688
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.26257
BASP1 brain abundant, membrane attached signal protein 1 -2.21013
INTS6 integrator complex subunit 6 -2.20928
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -2.20191
C2CD5 C2 calcium-dependent domain containing 5 -2.12354
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.05664
ANKRD10 ankyrin repeat domain 10 -2.04434
HAUS7 HAUS augmin-like complex, subunit 7 -2.00159