CRCGN015_MCF10A.TP53.M_24H:J03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazobenzene 11.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

170 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MRPL12 mitochondrial ribosomal protein L12 6.68844
STAP2 signal transducing adaptor family member 2 5.99127
CCDC85B coiled-coil domain containing 85B 5.12238
ANO10 anoctamin 10 4.55437
KIF5C kinesin family member 5C 3.753
ACAA1 acetyl-CoA acyltransferase 1 3.51246
CAPN1 calpain 1, (mu/I) large subunit 3.39415
BACE2 beta-site APP-cleaving enzyme 2 3.30008
CCND1 cyclin D1 3.17752
AGR2 anterior gradient 2 3.03497
IGHMBP2 immunoglobulin mu binding protein 2 3.00729
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.99003
SAC3D1 SAC3 domain containing 1 2.80088
PDCD11 programmed cell death 11 2.69527
EPHA3 EPH receptor A3 2.67148
EIF6 eukaryotic translation initiation factor 6 2.66361
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.66279
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 2.6457
NPDC1 neural proliferation, differentiation and control, 1 2.63236
MTG1 mitochondrial ribosome-associated GTPase 1 2.61395
NME1 NME/NM23 nucleoside diphosphate kinase 1 2.5634
HRAS Harvey rat sarcoma viral oncogene homolog 2.55777
LGMN legumain 2.51673
LOC112694756 uncharaterized LOC112694756 2.49074
COMP cartilage oligomeric matrix protein 2.45486
CERK ceramide kinase 2.4493
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.43001
ATP11B ATPase, class VI, type 11B 2.42816
TUBB4B tubulin, beta 4B class IVb 2.39941
BRMS1L breast cancer metastasis-suppressor 1-like 2.39799
ARL2 ADP-ribosylation factor-like 2 2.3915
JMJD7 jumonji domain containing 7 2.35041
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.35017
GSDMD gasdermin D 2.30183
TPST1 tyrosylprotein sulfotransferase 1 2.30179
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.28857
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.27334
MELK maternal embryonic leucine zipper kinase 2.26178
CCL20 chemokine (C-C motif) ligand 20 2.24475
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.20863
CBR1 carbonyl reductase 1 2.20298
TPD52L2 tumor protein D52-like 2 2.20079
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.19183
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.17081
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 2.17068
MRPL11 mitochondrial ribosomal protein L11 2.14902
CCT7 chaperonin containing TCP1, subunit 7 (eta) 2.14743
BORCS6 BLOC-1 related complex subunit 6 2.14547
COPS7A COP9 signalosome subunit 7A 2.13452
NCBP2 nuclear cap binding protein subunit 2, 20kDa 2.13332
TDG thymine-DNA glycosylase 2.1284
RPL36 ribosomal protein L36 2.12247
WRAP73 WD repeat containing, antisense to TP73 2.09327
AKAP8L A kinase (PRKA) anchor protein 8-like 2.08631
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 2.07473
MCUR1 mitochondrial calcium uniporter regulator 1 2.06863
ATP13A2 ATPase type 13A2 2.06547
TSC22D4 TSC22 domain family, member 4 2.06008
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.05832
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.05727
CYTH3 cytohesin 3 2.05131
SNF8 SNF8, ESCRT-II complex subunit 2.04458
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.03901
SST somatostatin 2.03665
AARSD1 alanyl-tRNA synthetase domain containing 1 2.0358
GFUS GDP-L-fucose synthase 2.02827
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.02633
SMG5 SMG5 nonsense mediated mRNA decay factor 2.0261
ASL argininosuccinate lyase 2.02557
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.02044

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -8.44032
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.22453
CCNB1 cyclin B1 -5.13018
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.03692
LAP3 leucine aminopeptidase 3 -4.90379
COG7 component of oligomeric golgi complex 7 -4.63966
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.47174
OXA1L oxidase (cytochrome c) assembly 1-like -3.94687
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.62273
UBFD1 ubiquitin family domain containing 1 -3.49343
LYPLA1 lysophospholipase I -3.14565
ASB8 ankyrin repeat and SOCS box containing 8 -2.95637
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.8181
KDM3A lysine (K)-specific demethylase 3A -2.8092
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -2.79828
A2M alpha-2-macroglobulin -2.72723
APLNR apelin receptor -2.7165
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.68434
R3HDM2 R3H domain containing 2 -2.64889
MT1G metallothionein 1G -2.63055
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.61361
HLA-DOB major histocompatibility complex, class II, DO beta -2.60447
PPP4C protein phosphatase 4, catalytic subunit -2.59261
TM9SF3 transmembrane 9 superfamily member 3 -2.56776
RPA3 replication protein A3, 14kDa -2.56758
PALB2 partner and localizer of BRCA2 -2.56703
AIM2 absent in melanoma 2 -2.53642
YBX2 Y box binding protein 2 -2.49851
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.49024
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.45938
TENT4A terminal nucleotidyltransferase 4A -2.45054
NPIPB5 nuclear pore complex interacting protein family, member B5 -2.40972
MTFR1 mitochondrial fission regulator 1 -2.39598
IRF9 interferon regulatory factor 9 -2.39463
SGF29 SAGA complex associated factor 29 -2.38725
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.38284
NOMO3 NODAL modulator 3 -2.36191
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -2.35633
MYH1 myosin, heavy chain 1, skeletal muscle, adult -2.34781
MT1H metallothionein 1H -2.34411
MUC5B mucin 5B, oligomeric mucus/gel-forming -2.32047
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -2.30456
TLK2 tousled-like kinase 2 -2.28232
IRS1 insulin receptor substrate 1 -2.27008
SLAMF8 SLAM family member 8 -2.25273
STAT1 signal transducer and activator of transcription 1, 91kDa -2.25208
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.232
TMEM106B transmembrane protein 106B -2.22603
CERT1 ceramide transporter 1 -2.22236
GABRP gamma-aminobutyric acid (GABA) A receptor, pi -2.21199
ERCC4 excision repair cross-complementation group 4 -2.20896
ZBTB39 zinc finger and BTB domain containing 39 -2.20863
PCNT pericentrin -2.20157
GBP1 guanylate binding protein 1, interferon-inducible -2.19345
LCMT1 leucine carboxyl methyltransferase 1 -2.19154
MX1 MX dynamin-like GTPase 1 -2.18127
NCSTN nicastrin -2.17715
LITAF lipopolysaccharide-induced TNF factor -2.16431
CD38 CD38 molecule -2.16303
KRT86 keratin 86, type II -2.16124
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide -2.15496
ERBIN erbb2 interacting protein -2.15141
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -2.14331
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.13995
MILR1 mast cell immunoglobulin-like receptor 1 -2.13953
MT1X metallothionein 1X -2.13871
PCGF1 polycomb group ring finger 1 -2.13681
OR2H1 olfactory receptor, family 2, subfamily H, member 1 -2.12265
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.11796
MRTFB myocardin related transcription factor B -2.11689
IFT140 intraflagellar transport 140 -2.11557
SSBP3 single stranded DNA binding protein 3 -2.10723
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 -2.10192
ZNF500 zinc finger protein 500 -2.10176
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.10001
HCK HCK proto-oncogene, Src family tyrosine kinase -2.09917
OASL 2'-5'-oligoadenylate synthetase-like -2.09816
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.09808
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.09317
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A -2.08532
CLASRP CLK4-associating serine/arginine rich protein -2.07488
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.07271
CXCL12 chemokine (C-X-C motif) ligand 12 -2.0701
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.06742
LAX1 lymphocyte transmembrane adaptor 1 -2.06171
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -2.05559
LOC127933115 uncharacterized LOC127933115 -2.05468
MT2A metallothionein 2A -2.05461
MT1F metallothionein 1F -2.05328
JAK2 Janus kinase 2 -2.05048
HIRIP3 HIRA interacting protein 3 -2.04211
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.03968
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.03746
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.03044
GALC galactosylceramidase -2.02859
DRP2 dystrophin related protein 2 -2.02528
RIBC2 RIB43A domain with coiled-coils 2 -2.02492
ADAMTSL4 ADAMTS-like 4 -2.01779
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.01714
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -2.00686