CRCGN015_MCF10A.TP53.M_24H:J08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethinyl estradiol 33.1 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:J08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.1032
TLR4 toll-like receptor 4 5.0632
HOXA5 homeobox A5 4.00545
TLCD3A TLC domain containing 3A 4.001
TOMM34 translocase of outer mitochondrial membrane 34 3.78945
PYCR1 pyrroline-5-carboxylate reductase 1 3.65485
IGHMBP2 immunoglobulin mu binding protein 2 3.1989
TPD52L2 tumor protein D52-like 2 3.18565
NRIP1 nuclear receptor interacting protein 1 3.03802
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.9965
NPC1 Niemann-Pick disease, type C1 2.74778
BAX BCL2-associated X protein 2.53405
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.5262
SAE1 SUMO1 activating enzyme subunit 1 2.4988
PCNA proliferating cell nuclear antigen 2.4762
PECR peroxisomal trans-2-enoyl-CoA reductase 2.38775
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.34565
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.33503
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.32035
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.2777
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.262
HEATR3 HEAT repeat containing 3 2.25605
MALT1 MALT1 paracaspase 2.24958
STRA6 stimulated by retinoic acid 6 2.2099
ADGRE2 adhesion G protein-coupled receptor E2 2.18165
TSKU tsukushi, small leucine rich proteoglycan 2.17045
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 2.1473
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 2.13525
LIPG lipase, endothelial 2.13335
CST3 cystatin C 2.10675
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough 2.1045
LAG3 lymphocyte-activation gene 3 2.10325
AGPS alkylglycerone phosphate synthase 2.0866
CFP complement factor properdin 2.08125
MTTP microsomal triglyceride transfer protein 2.0675
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 2.04035
CETN3 centrin, EF-hand protein, 3 2.03085
ZNF266 zinc finger protein 266 2.02125
SRPRB signal recognition particle receptor, B subunit 2.0076
MUC7 mucin 7, secreted 2.0071
FBXL12 F-box and leucine-rich repeat protein 12 2.0018

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -5.0547
CYCS cytochrome c, somatic -4.6625
YME1L1 YME1-like 1 ATPase -4.63143
BLCAP bladder cancer associated protein -4.4676
WASHC4 WASH complex subunit 4 -4.3108
MTERF3 mitochondrial transcription termination factor 3 -4.1456
CDC45 cell division cycle 45 -3.7279
ABI1 abl-interactor 1 -2.79857
CD81 CD81 molecule -2.7912
ATP11B ATPase, class VI, type 11B -2.69115
ACO2 aconitase 2, mitochondrial -2.6622
RBM38 RNA binding motif protein 38 -2.5641
DNAL4 dynein, axonemal, light chain 4 -2.4669
GGCT gamma-glutamylcyclotransferase -2.4367
PAGE4 P antigen family, member 4 (prostate associated) -2.43405
BCL7A B-cell CLL/lymphoma 7A -2.3698
GMPR guanosine monophosphate reductase -2.3691
ARHGAP8 Rho GTPase activating protein 8 -2.36482
ARMCX1 armadillo repeat containing, X-linked 1 -2.35265
RAD51C RAD51 paralog C -2.3344
RBM15B RNA binding motif protein 15B -2.33245
SIM1 single-minded family bHLH transcription factor 1 -2.3285
RTL10 retrotransposon Gag like 10 -2.3267
CTSD cathepsin D -2.32245
SOX12 SRY (sex determining region Y)-box 12 -2.29085
ESRP1 epithelial splicing regulatory protein 1 -2.2723
FAIM Fas apoptotic inhibitory molecule -2.26185
EFR3A EFR3 homolog A (S. cerevisiae) -2.2357
RFPL3 ret finger protein-like 3 -2.188
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.18245
RFPL2 ret finger protein-like 2 -2.182
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -2.18185
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -2.1785
ECHDC3 enoyl CoA hydratase domain containing 3 -2.17305
FABP3 fatty acid binding protein 3, muscle and heart -2.16458
ACTL8 actin-like 8 -2.1624
EPN3 epsin 3 -2.1604
CPTP ceramide-1-phosphate transfer protein -2.15595
CD177 CD177 molecule -2.14855
KRT19 keratin 19, type I -2.1408
EVPL envoplakin -2.13105
KLK11 kallikrein-related peptidase 11 -2.1267
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) -2.11275
KLK8 kallikrein-related peptidase 8 -2.1082
RNF208 ring finger protein 208 -2.1011
HRK harakiri, BCL2 interacting protein -2.07215
CLIC5 chloride intracellular channel 5 -2.06747
SERTAD2 SERTA domain containing 2 -2.06138
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.0608
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 -2.0559
TMEM131 transmembrane protein 131 -2.05305
PLCL1 phospholipase C-like 1 -2.047
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) -2.0415
CPLX3 complexin 3 -2.02615
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -2.02345
NINL ninein-like -2.0217
SP140L SP140 nuclear body protein-like -2.02075