| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | tretinoin 33.43 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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228 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:J11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HOXA5 | homeobox A5 | 6.58095 |
| TCEA2 | transcription elongation factor A (SII), 2 | 6.3265 |
| ZNF586 | zinc finger protein 586 | 6.3192 |
| GPER1 | G protein-coupled estrogen receptor 1 | 5.719 |
| COMP | cartilage oligomeric matrix protein | 5.58205 |
| CNPY3 | canopy FGF signaling regulator 3 | 5.33785 |
| IL1B | interleukin 1, beta | 5.1635 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 4.92815 |
| TBPL1 | TBP-like 1 | 4.38035 |
| SSBP2 | single-stranded DNA binding protein 2 | 4.31065 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 3.99675 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 3.87937 |
| PNKP | polynucleotide kinase 3'-phosphatase | 3.7583 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 3.6875 |
| CHMP6 | charged multivesicular body protein 6 | 3.43745 |
| ZNF134 | zinc finger protein 134 | 3.4122 |
| ZNF551 | zinc finger protein 551 | 3.40985 |
| NELL1 | NEL-like 1 (chicken) | 3.30095 |
| EML3 | echinoderm microtubule associated protein like 3 | 3.23798 |
| PANK4 | pantothenate kinase 4 | 3.2054 |
| MOK | MOK protein kinase | 3.13575 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 3.11175 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 3.08335 |
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 3.0567 |
| NOSIP | nitric oxide synthase interacting protein | 2.96695 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 2.94825 |
| NRIP1 | nuclear receptor interacting protein 1 | 2.94317 |
| ZNF329 | zinc finger protein 329 | 2.9342 |
| FCHO1 | FCH domain only 1 | 2.9236 |
| GNG7 | guanine nucleotide binding protein (G protein), gamma 7 | 2.89695 |
| ALX1 | ALX homeobox 1 | 2.85225 |
| SLC75A1 | solute carrier family 75 member 1 | 2.83505 |
| MCOLN1 | mucolipin 1 | 2.81835 |
| TASL | TLR adaptor interacting with endolysosomal SLC15A4 | 2.80945 |
| CDC45 | cell division cycle 45 | 2.8019 |
| SNX11 | sorting nexin 11 | 2.76845 |
| ZNF419 | zinc finger protein 419 | 2.76452 |
| ZNF606 | zinc finger protein 606 | 2.75985 |
| ZNF587 | zinc finger protein 587 | 2.75385 |
| CHN1 | chimerin 1 | 2.74765 |
| PRPF3 | pre-mRNA processing factor 3 | 2.712 |
| WRAP73 | WD repeat containing, antisense to TP73 | 2.6903 |
| PHACTR1 | phosphatase and actin regulator 1 | 2.6766 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 2.6436 |
| FBXO7 | F-box protein 7 | 2.60905 |
| BANP | BTG3 associated nuclear protein | 2.57255 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.5577 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 2.54495 |
| PRR5 | proline rich 5 (renal) | 2.53157 |
| ATAD3A | ATPase family, AAA domain containing 3A | 2.5241 |
| PENK | proenkephalin | 2.5123 |
| ZNF587B | zinc finger protein 587B | 2.4917 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | 2.471 |
| DPF2 | D4, zinc and double PHD fingers family 2 | 2.46765 |
| SAP25 | Sin3A-associated protein, 25kDa | 2.4162 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 2.4157 |
| METTL22 | methyltransferase like 22 | 2.41525 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 2.4012 |
| BIRC7 | baculoviral IAP repeat containing 7 | 2.38195 |
| RBM42 | RNA binding motif protein 42 | 2.37485 |
| SCAND1 | SCAN domain containing 1 | 2.36595 |
| EIF1B | eukaryotic translation initiation factor 1B | 2.35665 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 2.34615 |
| KEAP1 | kelch-like ECH-associated protein 1 | 2.3381 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.3322 |
| TFPT | TCF3 (E2A) fusion partner (in childhood Leukemia) | 2.32705 |
| MTA1 | metastasis associated 1 | 2.30942 |
| ZNF671 | zinc finger protein 671 | 2.309 |
| TSKU | tsukushi, small leucine rich proteoglycan | 2.30865 |
| CBR3 | carbonyl reductase 3 | 2.30365 |
| LCN1 | lipocalin 1 | 2.29705 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 2.27725 |
| MAD2L1BP | MAD2L1 binding protein | 2.2703 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | 2.26255 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 2.25417 |
| ORC6 | origin recognition complex, subunit 6 | 2.23745 |
| TATDN2 | TatD DNase domain containing 2 | 2.22795 |
| AGR2 | anterior gradient 2 | 2.2258 |
| UBE2M | ubiquitin-conjugating enzyme E2M | 2.2252 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 2.2092 |
| EXOSC4 | exosome component 4 | 2.2032 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | 2.191 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 2.1863 |
| BCL7B | B-cell CLL/lymphoma 7B | 2.17635 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 2.17417 |
| ECSIT | ECSIT signalling integrator | 2.1724 |
| ZNF813 | zinc finger protein 813 | 2.16415 |
| MORC3 | MORC family CW-type zinc finger 3 | 2.1488 |
| PDLIM1 | PDZ and LIM domain 1 | 2.1485 |
| GIN1 | gypsy retrotransposon integrase 1 | 2.13465 |
| ZNF143 | zinc finger protein 143 | 2.11225 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 2.10255 |
| COG2 | component of oligomeric golgi complex 2 | 2.09275 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 2.09043 |
| CCDC85B | coiled-coil domain containing 85B | 2.0876 |
| RSBN1 | round spermatid basic protein 1 | 2.08425 |
| ZNF211 | zinc finger protein 211 | 2.07905 |
| ACTL6A | actin-like 6A | 2.0786 |
| HSPBP1 | HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 | 2.0709 |
| P3H1 | prolyl 3-hydroxylase 1 | 2.0616 |
| CCNE1 | cyclin E1 | 2.0613 |
| TDP2 | tyrosyl-DNA phosphodiesterase 2 | 2.06085 |
| GMEB1 | glucocorticoid modulatory element binding protein 1 | 2.0583 |
| PHGDH | phosphoglycerate dehydrogenase | 2.03865 |
| SNRNP40 | small nuclear ribonucleoprotein 40kDa (U5) | 2.0366 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 2.0342 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 2.032 |
| TBC1D10C | TBC1 domain family, member 10C | 2.0313 |
| ZNF304 | zinc finger protein 304 | 2.0263 |
| MAP2K3 | mitogen-activated protein kinase kinase 3 | 2.02448 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 2.02305 |
| HAAO | 3-hydroxyanthranilate 3,4-dioxygenase | 2.01815 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | 2.01375 |
| PRKAB2 | protein kinase, AMP-activated, beta 2 non-catalytic subunit | 2.0121 |
| Symbol | Name | Standardized Value |
|---|---|---|
| C2CD5 | C2 calcium-dependent domain containing 5 | -6.00905 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -5.55885 |
| TCTA | T-cell leukemia translocation altered | -5.3698 |
| S100A4 | S100 calcium binding protein A4 | -5.1676 |
| ANXA2 | annexin A2 | -4.73725 |
| UBE3C | ubiquitin protein ligase E3C | -4.57545 |
| TOR1A | torsin family 1, member A (torsin A) | -4.13185 |
| NCK2 | NCK adaptor protein 2 | -3.96545 |
| TCTN1 | tectonic family member 1 | -3.95455 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -3.88 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.8399 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -3.8027 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -3.66825 |
| GNAS | GNAS complex locus | -3.52284 |
| LDHD | lactate dehydrogenase D | -3.5098 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.22815 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | -3.09825 |
| METRN | meteorin, glial cell differentiation regulator | -3.09115 |
| PSMD5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | -3.0599 |
| ANKRD10 | ankyrin repeat domain 10 | -2.97725 |
| CORO1A | coronin, actin binding protein, 1A | -2.9619 |
| CD53 | CD53 molecule | -2.894 |
| CRTAP | cartilage associated protein | -2.87545 |
| MSMO1 | methylsterol monooxygenase 1 | -2.85645 |
| C1QBP | complement component 1, q subcomponent binding protein | -2.82043 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -2.77295 |
| PCYOX1 | prenylcysteine oxidase 1 | -2.7727 |
| GSTK1 | glutathione S-transferase kappa 1 | -2.7686 |
| BBS1 | Bardet-Biedl syndrome 1 | -2.756 |
| TUBA4A | tubulin, alpha 4a | -2.7517 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 | -2.73435 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -2.6939 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | -2.69265 |
| TP53 | tumor protein p53 | -2.69117 |
| BCL2L2 | BCL2-like 2 | -2.6799 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -2.67665 |
| NDUFA10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa | -2.67415 |
| CDH18 | cadherin 18, type 2 | -2.63305 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -2.62072 |
| CAPN2 | calpain 2, (m/II) large subunit | -2.61098 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | -2.5915 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -2.5661 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -2.56445 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | -2.55085 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.54445 |
| INSIG1 | insulin induced gene 1 | -2.51758 |
| SERINC1 | serine incorporator 1 | -2.51445 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.51138 |
| ECD | ecdysoneless homolog (Drosophila) | -2.5021 |
| CTSC | cathepsin C | -2.47125 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -2.44765 |
| ITM2B | integral membrane protein 2B | -2.43042 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | -2.41695 |
| CANX | calnexin | -2.41528 |
| MAPK8 | mitogen-activated protein kinase 8 | -2.39297 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -2.3929 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | -2.387 |
| NUP133 | nucleoporin 133kDa | -2.3861 |
| JAK1 | Janus kinase 1 | -2.37495 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -2.37035 |
| ADA2 | adenosine deaminase 2 | -2.35715 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -2.3534 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.34685 |
| CCDC25 | coiled-coil domain containing 25 | -2.346 |
| INTS3 | integrator complex subunit 3 | -2.33515 |
| MLEC | malectin | -2.30675 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -2.2987 |
| CDC25B | cell division cycle 25B | -2.29805 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -2.29225 |
| TMEM43 | transmembrane protein 43 | -2.29125 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | -2.28625 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | -2.28475 |
| WWC1 | WW and C2 domain containing 1 | -2.27285 |
| HMGA2 | high mobility group AT-hook 2 | -2.26935 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.2567 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | -2.24713 |
| MRPS16 | mitochondrial ribosomal protein S16 | -2.2336 |
| PYGL | phosphorylase, glycogen, liver | -2.22815 |
| CDV3 | CDV3 homolog (mouse) | -2.22785 |
| MYOM2 | myomesin 2 | -2.20855 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -2.18572 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | -2.172 |
| TTPAL | tocopherol (alpha) transfer protein-like | -2.16455 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | -2.1643 |
| GOLGA3 | golgin A3 | -2.16075 |
| SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 | -2.1566 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | -2.1539 |
| NAA35 | N(alpha)-acetyltransferase 35, NatC auxiliary subunit | -2.1481 |
| CRYAB | crystallin, alpha B | -2.1365 |
| EFCAB14 | EF-hand calcium binding domain 14 | -2.13206 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.1252 |
| EGFR | epidermal growth factor receptor | -2.11458 |
| CHMP1B | charged multivesicular body protein 1B | -2.114 |
| SPEG | SPEG complex locus | -2.1104 |
| CCDC86 | coiled-coil domain containing 86 | -2.10955 |
| CBR1 | carbonyl reductase 1 | -2.09775 |
| CCDC91 | coiled-coil domain containing 91 | -2.089 |
| ANKFY1 | ankyrin repeat and FYVE domain containing 1 | -2.08815 |
| USH1C | Usher syndrome 1C (autosomal recessive, severe) | -2.08605 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -2.08565 |
| FOXO3 | forkhead box O3 | -2.08096 |
| AACS | acetoacetyl-CoA synthetase | -2.07575 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -2.054 |
| GFUS | GDP-L-fucose synthase | -2.05002 |
| CTSH | cathepsin H | -2.04865 |
| CLSTN3 | calsyntenin 3 | -2.04395 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | -2.04215 |
| SRSF6 | serine/arginine-rich splicing factor 6 | -2.04148 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -2.0334 |
| SULT1C4 | sulfotransferase family, cytosolic, 1C, member 4 | -2.03195 |
| CYBRD1 | cytochrome b reductase 1 | -2.02005 |
| AOX1 | aldehyde oxidase 1 | -2.01555 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.01285 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | -2.01125 |
