CRCGN015_MCF10A.TP53.M_24H:J12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 11.14 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

127 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:J12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 10.0
HOXA5 homeobox A5 6.88725
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 6.5493
TCEA2 transcription elongation factor A (SII), 2 6.32805
CCP110 centriolar coiled coil protein 110kDa 5.33725
IL1B interleukin 1, beta 5.0312
CXCL2 chemokine (C-X-C motif) ligand 2 4.97855
WFS1 Wolfram syndrome 1 (wolframin) 4.24945
KDM5D lysine (K)-specific demethylase 5D 3.9085
WIF1 WNT inhibitory factor 1 3.87675
FHL2 four and a half LIM domains 2 3.6687
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.65303
MEA1 male-enhanced antigen 1 3.56535
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.36725
CNRIP1 cannabinoid receptor interacting protein 1 3.2743
BAG3 BCL2-associated athanogene 3 3.2238
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.0979
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.01762
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.99605
CGRRF1 cell growth regulator with ring finger domain 1 2.97115
CXCL3 chemokine (C-X-C motif) ligand 3 2.9108
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.89655
CCNE2 cyclin E2 2.89435
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.88641
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.85185
RBKS ribokinase 2.61928
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.5828
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.40125
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.36228
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.35485
SKAP2 src kinase associated phosphoprotein 2 2.33098
UPP1 uridine phosphorylase 1 2.3166
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.29775
NRIP1 nuclear receptor interacting protein 1 2.28857
MRPS10 mitochondrial ribosomal protein S10 2.266
EVI2A ecotropic viral integration site 2A 2.2537
MRPL37 mitochondrial ribosomal protein L37 2.23815
TOMM34 translocase of outer mitochondrial membrane 34 2.2355
FIP1L1 factor interacting with PAPOLA and CPSF1 2.22545
GPN3 GPN-loop GTPase 3 2.1925
DSG2 desmoglein 2 2.18785
TSPAN6 tetraspanin 6 2.13205
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.11803
SIPA1L1 signal-induced proliferation-associated 1 like 1 2.11337
SMAD3 SMAD family member 3 2.10671
ETNPPL ethanolamine-phosphate phospho-lyase 2.07845
PLSCR1 phospholipid scramblase 1 2.06643
IL13RA2 interleukin 13 receptor, alpha 2 2.0417
LSR lipolysis stimulated lipoprotein receptor 2.03515
TXNRD1 thioredoxin reductase 1 2.03
BLTP3B bridge-like lipid transfer protein family member 3B 2.02215
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 2.01205

decreased expression

Symbol Name Standardized Value
NSDHL NAD(P) dependent steroid dehydrogenase-like -6.11582
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.32355
MSMO1 methylsterol monooxygenase 1 -5.2027
STXBP2 syntaxin binding protein 2 -4.98565
S100A4 S100 calcium binding protein A4 -4.732
YME1L1 YME1-like 1 ATPase -4.70022
CD320 CD320 molecule -4.40055
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.77588
ANKRD10 ankyrin repeat domain 10 -3.37325
FOS FBJ murine osteosarcoma viral oncogene homolog -3.34805
SLC35E2B solute carrier family 35, member E2B -3.29165
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.24435
UBA1 ubiquitin-like modifier activating enzyme 1 -3.00805
NUSAP1 nucleolar and spindle associated protein 1 -3.0029
SMC1A structural maintenance of chromosomes 1A -2.98693
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.92725
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.91162
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -2.81875
IL2RG interleukin 2 receptor, gamma -2.81275
PUDP pseudouridine 5'-phosphatase -2.7997
TMEM187 transmembrane protein 187 -2.75275
TRIM58 tripartite motif containing 58 -2.7078
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.66073
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.61045
KRT14 keratin 14, type I -2.5931
KDM5C lysine (K)-specific demethylase 5C -2.5889
MVD mevalonate (diphospho) decarboxylase -2.58805
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.55505
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.4961
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.48935
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.45439
TMEM164 transmembrane protein 164 -2.4323
IRAK1 interleukin-1 receptor-associated kinase 1 -2.3924
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 -2.389
PRMT7 protein arginine methyltransferase 7 -2.3772
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -2.3752
KLF1 Kruppel-like factor 1 (erythroid) -2.37395
PDZK1 PDZ domain containing 1 -2.3717
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.3657
TPO thyroid peroxidase -2.3563
KDM6A lysine (K)-specific demethylase 6A -2.3551
TNS1 tensin 1 -2.34193
ADAM7 ADAM metallopeptidase domain 7 -2.3349
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.32865
PGAP2 post-GPI attachment to proteins 2 -2.31327
MPC2 mitochondrial pyruvate carrier 2 -2.2793
TM7SF2 transmembrane 7 superfamily member 2 -2.25235
USP8 ubiquitin specific peptidase 8 -2.2424
ZIM3 zinc finger, imprinted 3 -2.2165
STAG2 stromal antigen 2 -2.19
PDIA2 protein disulfide isomerase family A, member 2 -2.18055
MUC6 mucin 6, oligomeric mucus/gel-forming -2.16225
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.1606
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -2.15175
FOXO3 forkhead box O3 -2.14788
RNF123 ring finger protein 123 -2.146
WNT4 wingless-type MMTV integration site family, member 4 -2.12065
MKNK2 MAP kinase interacting serine/threonine kinase 2 -2.1111
IRF2 interferon regulatory factor 2 -2.1069
LTBP1 latent transforming growth factor beta binding protein 1 -2.1052
LOC124906741 sperm-associated antigen 11B-like -2.1004
THOC2 THO complex 2 -2.09398
LUM lumican -2.08985
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.07825
DNM2 dynamin 2 -2.0704
CETN2 centrin, EF-hand protein, 2 -2.0647
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like -2.063
TCN2 transcobalamin II -2.06225
RNF44 ring finger protein 44 -2.05875
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 -2.05775
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -2.04352
EDDM3A epididymal protein 3A -2.03955
MXRA5 matrix-remodelling associated 5 -2.0316
ANXA2 annexin A2 -2.00877
FAT2 FAT atypical cadherin 2 -2.00055