CRCGN015_MCF10A.TP53.M_24H:J19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description simazine 102.07 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:J19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 5.66881
CDCA4 cell division cycle associated 4 5.2838
SPAG4 sperm associated antigen 4 5.26155
C2CD2 C2 calcium-dependent domain containing 2 4.62165
GRB10 growth factor receptor-bound protein 10 4.57675
SSBP2 single-stranded DNA binding protein 2 4.55263
PRKCH protein kinase C, eta 4.36353
HBB hemoglobin, beta 3.91473
EPHB2 EPH receptor B2 3.1403
RBKS ribokinase 3.05395
CCNA1 cyclin A1 2.87535
NOSIP nitric oxide synthase interacting protein 2.85975
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.79118
PFDN1 prefoldin subunit 1 2.7454
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.3529
MRPL33 mitochondrial ribosomal protein L33 2.2107
ZNF32 zinc finger protein 32 2.17545
SNX15 sorting nexin 15 2.1067
FAM171A1 family with sequence similarity 171, member A1 2.0314
HBA1 hemoglobin, alpha 1 2.01592
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 2.0154
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 2.006

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -4.97132
CHIC2 cysteine-rich hydrophobic domain 2 -4.8641
CD81 CD81 molecule -3.1042
ACAA1 acetyl-CoA acyltransferase 1 -2.85
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.56795
FASN fatty acid synthase -2.4664
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.41458
STK25 serine/threonine kinase 25 -2.3122
DUSP14 dual specificity phosphatase 14 -2.0874
SIN3B SIN3 transcription regulator family member B -2.06378
STAT1 signal transducer and activator of transcription 1, 91kDa -2.05492