CRCGN015_MCF10A.TP53.M_24H:J20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description simazine 34.02 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:J20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 10.0
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 5.16012
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.11055
SPAG4 sperm associated antigen 4 4.90755
WIF1 WNT inhibitory factor 1 4.8629
CLNS1A chloride channel, nucleotide-sensitive, 1A 4.63425
AKT1 v-akt murine thymoma viral oncogene homolog 1 4.0699
KDM5A lysine (K)-specific demethylase 5A 4.0485
THAP12 THAP domain containing 12 3.9603
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 3.8526
AAMDC adipogenesis associated, Mth938 domain containing 3.784
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 3.4125
DPH2 DPH2 homolog (S. cerevisiae) 3.30295
ALG8 ALG8, alpha-1,3-glucosyltransferase 3.2769
PKN1 protein kinase N1 3.1811
EMSY EMSY transcriptional repressor, BRCA2 interacting 3.07755
RSF1 remodeling and spacing factor 1 3.0767
HBB hemoglobin, beta 2.82052
FOXM1 forkhead box M1 2.8167
PDLIM1 PDZ and LIM domain 1 2.7755
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.54785
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 2.542
DHCR7 7-dehydrocholesterol reductase 2.38865
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.3884
LDHA lactate dehydrogenase A 2.37225
FAM13A family with sequence similarity 13, member A 2.33603
SPA17 sperm autoantigenic protein 17 2.3067
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.2793
FHL5 four and a half LIM domains 5 2.2282
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 2.20475
CD36 CD36 molecule (thrombospondin receptor) 2.2022
SPATS2 spermatogenesis associated, serine-rich 2 2.1761
MRC1 mannose receptor, C type 1 2.1623
ARID4A AT rich interactive domain 4A (RBP1-like) 2.1513
EPS8 epidermal growth factor receptor pathway substrate 8 2.0916
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2.07687
APOOL apolipoprotein O-like 2.06023
NRN1 neuritin 1 2.03905
MTARC1 mitochondrial amidoxime reducing component 1 2.03705
BAX BCL2-associated X protein 2.03595
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.0335
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.0286
F8 coagulation factor VIII, procoagulant component 2.0261
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.015
NTS neurotensin 2.0136
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.00425

decreased expression

Symbol Name Standardized Value
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -5.17373
TUBB6 tubulin, beta 6 class V -4.92905
CAB39 calcium binding protein 39 -4.5142
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -4.28935
PMM2 phosphomannomutase 2 -4.0283
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.9559
BLCAP bladder cancer associated protein -3.2409
ACAA1 acetyl-CoA acyltransferase 1 -3.20162
RPS5 ribosomal protein S5 -2.91
LINC02762 long intergenic non-protein coding RNA 2762 -2.66533
EPHX2 epoxide hydrolase 2, cytoplasmic -2.3882
VNN1 vanin 1 -2.37795
PTH1R parathyroid hormone 1 receptor -2.35225
RAI14 retinoic acid induced 14 -2.33525
ANXA2 annexin A2 -2.26465
PNRC2 proline-rich nuclear receptor coactivator 2 -2.19315
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.08115
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.06545
CERS2 ceramide synthase 2 -2.0654
CD79B CD79b molecule, immunoglobulin-associated beta -2.0541