CRCGN015_MCF10A.TP53.M_24H:J21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description simazine 11.34 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

124 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:J21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 6.03425
TRIM13 tripartite motif containing 13 5.8128
LYN LYN proto-oncogene, Src family tyrosine kinase 5.25832
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.05657
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.96865
MAMLD1 mastermind-like domain containing 1 4.9334
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.7771
NUCB2 nucleobindin 2 3.99235
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.8863
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 3.33705
EPN2 epsin 2 3.29907
PECR peroxisomal trans-2-enoyl-CoA reductase 2.8801
MTA2 metastasis associated 1 family, member 2 2.84085
THRAP3 thyroid hormone receptor associated protein 3 2.81135
LGMN legumain 2.7803
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.7383
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.68685
NUTF2 nuclear transport factor 2 2.6732
CEPT1 choline/ethanolamine phosphotransferase 1 2.6377
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.59725
BZW2 basic leucine zipper and W2 domains 2 2.59405
RNFT2 ring finger protein, transmembrane 2 2.5808
LPL lipoprotein lipase 2.5741
GSDME gasdermin E 2.53365
ZBED4 zinc finger, BED-type containing 4 2.52863
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.5193
NLGN3 neuroligin 3 2.49835
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 2.4573
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.45703
INCENP inner centromere protein antigens 135/155kDa 2.45665
ZNF227 zinc finger protein 227 2.42085
TMEM209 transmembrane protein 209 2.41155
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.38555
GFPT2 glutamine-fructose-6-phosphate transaminase 2 2.37355
BPIFA1 BPI fold containing family A, member 1 2.321
ETV6 ets variant 6 2.30165
NES nestin 2.3015
ZYX zyxin 2.28842
BTN1A1 butyrophilin, subfamily 1, member A1 2.27985
TP53 tumor protein p53 2.27603
SMIM41 small integral membrane protein 41 2.27025
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 2.269
MSMB microseminoprotein, beta- 2.25805
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.25665
ZBTB6 zinc finger and BTB domain containing 6 2.25655
TMLHE trimethyllysine hydroxylase, epsilon 2.25635
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.2518
IFI6 interferon, alpha-inducible protein 6 2.20245
DPF3 D4, zinc and double PHD fingers, family 3 2.19315
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 2.19305
ZFP91 ZFP91 zinc finger protein 2.19295
PTPRE protein tyrosine phosphatase, receptor type, E 2.17625
ZNF260 zinc finger protein 260 2.17263
EHF ets homologous factor 2.1506
GRHL2 grainyhead-like 2 (Drosophila) 2.141
GM2A GM2 ganglioside activator 2.12898
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 2.1246
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.1096
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.09845
LIMD1 LIM domains containing 1 2.0978
PRKDC protein kinase, DNA-activated, catalytic polypeptide 2.08807
SPATA6 spermatogenesis associated 6 2.08292
ZNF365 zinc finger protein 365 2.081
SRSF6 serine/arginine-rich splicing factor 6 2.07735
DCTN4 dynactin 4 (p62) 2.0713
DNAH3 dynein, axonemal, heavy chain 3 2.0712
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 2.06305
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.05972
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2.0594
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 2.05175
BTBD1 BTB (POZ) domain containing 1 2.0487
ZNF286A zinc finger protein 286A 2.0472
PPCS phosphopantothenoylcysteine synthetase 2.04265
MDM4 MDM4, p53 regulator 2.0277
LYSET lysosomal enzyme trafficking factor 2.0261
ADPRH ADP-ribosylarginine hydrolase 2.0186
NRBF2 nuclear receptor binding factor 2 2.01855
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.01125
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.00575
PRR3 proline rich 3 2.00505

decreased expression

Symbol Name Standardized Value
TUBA4A tubulin, alpha 4a -5.0592
PUF60 poly-U binding splicing factor 60KDa -4.8975
TXNDC9 thioredoxin domain containing 9 -4.86547
PGAM4 phosphoglycerate mutase family member 4 -4.7719
CDK4 cyclin-dependent kinase 4 -4.4956
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.62685
ACAA1 acetyl-CoA acyltransferase 1 -3.22475
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.17585
CREB1 cAMP responsive element binding protein 1 -3.04122
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -3.0074
NT5DC2 5'-nucleotidase domain containing 2 -2.99615
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.98008
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.9507
REXO2 RNA exonuclease 2 -2.88735
CORO1A coronin, actin binding protein, 1A -2.7661
KIF11 kinesin family member 11 -2.72185
ECSIT ECSIT signalling integrator -2.6965
COTL1 coactosin-like F-actin binding protein 1 -2.69025
MLH1 mutL homolog 1 -2.6731
REV1 REV1, polymerase (DNA directed) -2.6618
SCRIB scribbled planar cell polarity protein -2.5168
TENM3 teneurin transmembrane protein 3 -2.50465
TAC1 tachykinin, precursor 1 -2.46195
GOLT1A golgi transport 1A -2.45835
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.44575
BOP1 block of proliferation 1 -2.40403
CXCL6 chemokine (C-X-C motif) ligand 6 -2.38235
SLIT2 slit homolog 2 (Drosophila) -2.37765
RPS5 ribosomal protein S5 -2.3448
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.34268
GSDMD gasdermin D -2.3367
NADSYN1 NAD synthetase 1 -2.3071
IL11RA interleukin 11 receptor, alpha -2.25995
TNRC6B trinucleotide repeat containing 6B -2.2338
LMAN2L lectin, mannose-binding 2-like -2.2255
STK26 serine/threonine protein kinase 26 -2.2085
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -2.2061
EIF6 eukaryotic translation initiation factor 6 -2.17575
ETNPPL ethanolamine-phosphate phospho-lyase -2.146
UNC50 unc-50 homolog (C. elegans) -2.11455
PYCR3 pyrroline-5-carboxylate reductase 3 -2.07085
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.05575
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.0425
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.009