CRCGN015_MCF10A.TP53.M_24H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 1.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

161 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.8065
UBQLN2 ubiquilin 2 5.4913
IL1B interleukin 1, beta 5.3672
MAMLD1 mastermind-like domain containing 1 4.7401
HOXA5 homeobox A5 4.383
STAP2 signal transducing adaptor family member 2 4.28175
MEF2C myocyte enhancer factor 2C 4.2192
CXCL2 chemokine (C-X-C motif) ligand 2 4.1224
HYOU1 hypoxia up-regulated 1 4.02265
UGDH UDP-glucose 6-dehydrogenase 3.99115
RAB31 RAB31, member RAS oncogene family 3.80242
TNIP1 TNFAIP3 interacting protein 1 3.7915
BPHL biphenyl hydrolase-like (serine hydrolase) 3.6511
TPM1 tropomyosin 1 (alpha) 3.42941
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.41583
TSEN2 TSEN2 tRNA splicing endonuclease subunit 3.3764
COMP cartilage oligomeric matrix protein 3.25105
IGHMBP2 immunoglobulin mu binding protein 2 3.02833
FGF17 fibroblast growth factor 17 2.8371
MYL11 myosin light chain 11 2.80945
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.7782
MTA2 metastasis associated 1 family, member 2 2.7601
CDC45 cell division cycle 45 2.66845
SPEF1 sperm flagellar 1 2.6197
ITPKA inositol-trisphosphate 3-kinase A 2.5697
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.5598
CDCA4 cell division cycle associated 4 2.5543
DGKI diacylglycerol kinase, iota 2.5181
MYBPH myosin binding protein H 2.4531
MTSS2 MTSS I-BAR domain containing 2 2.43655
MTA1 metastasis associated 1 2.41232
PXDNL peroxidasin-like 2.40905
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.3883
SMAD3 SMAD family member 3 2.37964
FHL2 four and a half LIM domains 2 2.3768
MROH7 maestro heat-like repeat family member 7 2.3599
TSNAXIP1 translin-associated factor X interacting protein 1 2.34505
KIF17 kinesin family member 17 2.3437
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.3336
CNPY3 canopy FGF signaling regulator 3 2.3248
NXN nucleoredoxin 2.3135
WNT5B wingless-type MMTV integration site family, member 5B 2.31255
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 2.3098
SQOR sulfide quinone oxidoreductase 2.30535
CXCL3 chemokine (C-X-C motif) ligand 3 2.29435
MTM1 myotubularin 1 2.29317
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.2879
SCCPDH saccharopine dehydrogenase (putative) 2.2818
PRM2 protamine 2 2.2436
GPR17 G protein-coupled receptor 17 2.23545
PYGM phosphorylase, glycogen, muscle 2.2105
ACTL7B actin-like 7B 2.1913
GRAPL GRB2-related adaptor protein-like 2.1866
BCAN brevican 2.18627
AGR2 anterior gradient 2 2.18095
GPR25 G protein-coupled receptor 25 2.18
TUBB6 tubulin, beta 6 class V 2.17945
CCND1 cyclin D1 2.16768
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.1662
CCKAR cholecystokinin A receptor 2.15125
MEGF6 multiple EGF-like-domains 6 2.14685
GDI1 GDP dissociation inhibitor 1 2.1367
PWP1 PWP1 homolog (S. cerevisiae) 2.13097
CSDC2 cold shock domain containing C2, RNA binding 2.12705
FGF6 fibroblast growth factor 6 2.126
DENND4B DENN/MADD domain containing 4B 2.1259
PRDM8 PR domain containing 8 2.1239
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.11495
JRK Jrk homolog (mouse) 2.11293
NECAB2 N-terminal EF-hand calcium binding protein 2 2.10565
RBMX2 RNA binding motif protein, X-linked 2 2.10527
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.103
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.10075
MYF6 myogenic factor 6 (herculin) 2.09225
MOK MOK protein kinase 2.09215
CATSPERG catsper channel auxiliary subunit gamma 2.08985
GDF2 growth differentiation factor 2 2.08915
RAB3D RAB3D, member RAS oncogene family 2.08865
DNAAF11 dynein axonemal assembly factor 11 2.08205
CHAD chondroadherin 2.07725
GAS6 growth arrest-specific 6 2.07687
ELF4 E74-like factor 4 (ets domain transcription factor) 2.07522
CDC25B cell division cycle 25B 2.07125
BAMBI BMP and activin membrane-bound inhibitor 2.06665
ODF1 outer dense fiber of sperm tails 1 2.06315
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.058
MYBBP1A MYB binding protein (P160) 1a 2.056
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.0542
DRC3 dynein regulatory complex subunit 3 2.0508
RABIF RAB interacting factor 2.04862
NGF nerve growth factor (beta polypeptide) 2.04525
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.045
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.04055
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.03875
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 2.0377
AZU1 azurocidin 1 2.0334
SCN5A sodium channel, voltage gated, type V alpha subunit 2.0253
TOM1L2 target of myb1-like 2 (chicken) 2.0238
WNT1 wingless-type MMTV integration site family, member 1 2.01875
PEX10 peroxisomal biogenesis factor 10 2.01715
VAT1 vesicle amine transport 1 2.01705
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.008
PUF60 poly-U binding splicing factor 60KDa 2.00745
TWNK twinkle mtDNA helicase 2.0037
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.00325
CCDC70 coiled-coil domain containing 70 2.00225
FST follistatin 2.0007
GJD2 gap junction protein, delta 2, 36kDa 2.0007

decreased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 -5.59835
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -5.0201
HMG20B high mobility group 20B -4.83667
ANKRD10 ankyrin repeat domain 10 -4.51005
TCTA T-cell leukemia translocation altered -4.2681
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.7476
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -3.3428
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.32345
GLRX glutaredoxin (thioltransferase) -3.239
ANXA2 annexin A2 -3.1531
LDHD lactate dehydrogenase D -3.07945
S100A4 S100 calcium binding protein A4 -3.0321
DNM1L dynamin 1-like -3.0287
SGK1 serum/glucocorticoid regulated kinase 1 -2.9644
CDK7 cyclin-dependent kinase 7 -2.8434
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.7979
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -2.66525
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.6595
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.63865
IGFBP6 insulin-like growth factor binding protein 6 -2.5688
NRIP1 nuclear receptor interacting protein 1 -2.55123
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -2.53503
MAGEA12 melanoma antigen family A12 -2.51215
FASN fatty acid synthase -2.49852
DDIT4 DNA-damage-inducible transcript 4 -2.4105
FAIM Fas apoptotic inhibitory molecule -2.36965
CISD1 CDGSH iron sulfur domain 1 -2.33915
RPS5 ribosomal protein S5 -2.33425
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.3255
PDCL3 phosducin-like 3 -2.3221
LOC100533997 MAGEA10-MAGEA5 readthrough -2.29085
RBM7 RNA binding motif protein 7 -2.2694
ECD ecdysoneless homolog (Drosophila) -2.2603
INSIG1 insulin induced gene 1 -2.25772
CBR1 carbonyl reductase 1 -2.2377
TAC4 tachykinin 4 (hemokinin) -2.23645
COL6A3 collagen, type VI, alpha 3 -2.20075
CRYZ crystallin, zeta (quinone reductase) -2.2007
ECSIT ECSIT signalling integrator -2.18755
MPC2 mitochondrial pyruvate carrier 2 -2.17765
OXSR1 oxidative stress responsive 1 -2.1426
CGRRF1 cell growth regulator with ring finger domain 1 -2.127
AGPS alkylglycerone phosphate synthase -2.1204
SESN1 sestrin 1 -2.1144
MAGEA4 melanoma antigen family A4 -2.1038
ITCH itchy E3 ubiquitin protein ligase -2.1
TMEM135 transmembrane protein 135 -2.093
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.08685
UBXN7 UBX domain protein 7 -2.07023
MX2 MX dynamin-like GTPase 2 -2.06205
ZMYM2 zinc finger, MYM-type 2 -2.04972
NEFL neurofilament, light polypeptide -2.01835
GRWD1 glutamate-rich WD repeat containing 1 -2.00255