CRCGN015_MCF10A.TP53.M_24H:K13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aspirin 99.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:K13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.98715
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.76255
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.7439
DENND2D DENN/MADD domain containing 2D 4.1385
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.6221
HOXA5 homeobox A5 3.03305
AGR2 anterior gradient 2 3.0278
TBXA2R thromboxane A2 receptor 2.70108
PECR peroxisomal trans-2-enoyl-CoA reductase 2.3842
NRIP1 nuclear receptor interacting protein 1 2.32805
CCN3 cellular communication network factor 3 2.30617
TGFBI transforming growth factor, beta-induced, 68kDa 2.1742
PDIA5 protein disulfide isomerase family A, member 5 2.1661
LOC100533997 MAGEA10-MAGEA5 readthrough 2.1655
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.11723
HBB hemoglobin, beta 2.06867
SKAP2 src kinase associated phosphoprotein 2 2.00152
MAGEA1 melanoma antigen family A1 2.00145
COPS7A COP9 signalosome subunit 7A 2.0004

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -4.86655
MSMO1 methylsterol monooxygenase 1 -4.6685
ELAC2 elaC ribonuclease Z 2 -3.6345
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.53193
PRCP prolylcarboxypeptidase (angiotensinase C) -3.1173
HSPA1A heat shock 70kDa protein 1A -3.0602
FASN fatty acid synthase -2.93731
CD320 CD320 molecule -2.841
MTERF3 mitochondrial transcription termination factor 3 -2.61265
FBXO21 F-box protein 21 -2.54615
SOAT2 sterol O-acyltransferase 2 -2.4197
BASP1 brain abundant, membrane attached signal protein 1 -2.22035
DPP6 dipeptidyl-peptidase 6 -2.1635
IFNGR1 interferon gamma receptor 1 -2.14275
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.14005
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.12392
CRMP1 collapsin response mediator protein 1 -2.0633
CSRP1 cysteine and glycine-rich protein 1 -2.02167
HPCA hippocalcin -2.00245