CRCGN015_MCF10A.TP53.M_24H:K15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aspirin 11.03 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:K15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GATA3 GATA binding protein 3 5.20013
STK10 serine/threonine kinase 10 4.95695
ADAM10 ADAM metallopeptidase domain 10 4.93212
WFS1 Wolfram syndrome 1 (wolframin) 4.6675
GRB10 growth factor receptor-bound protein 10 3.39647
VAV3 vav 3 guanine nucleotide exchange factor 3.17222
KDM5D lysine (K)-specific demethylase 5D 3.11265
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.02125
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.9958
MELK maternal embryonic leucine zipper kinase 2.99475
CNRIP1 cannabinoid receptor interacting protein 1 2.95395
SATB1 SATB homeobox 1 2.93685
HOXA5 homeobox A5 2.44285
RPS4Y1 ribosomal protein S4, Y-linked 1 2.28495
NFIL3 nuclear factor, interleukin 3 regulated 2.21175
USP9Y ubiquitin specific peptidase 9, Y-linked 2.14512
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.11465
RAB8B RAB8B, member RAS oncogene family 2.09475
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.09297
TNPO3 transportin 3 2.04395
ADRB2 adrenoceptor beta 2, surface 2.0236
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.0169

decreased expression

Symbol Name Standardized Value
PRPF4 pre-mRNA processing factor 4 -5.45092
FASTKD5 FAST kinase domains 5 -5.1475
DYNLT3 dynein, light chain, Tctex-type 3 -5.04715
DERA deoxyribose-phosphate aldolase (putative) -5.0
UFM1 ubiquitin-fold modifier 1 -4.8355
CCNB1 cyclin B1 -4.6908
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.3678
LYPLA1 lysophospholipase I -4.08885
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -3.8126
SRFBP1 serum response factor binding protein 1 -3.5055
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.34338
GAS2 growth arrest-specific 2 -3.30345
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -3.26895
UBA1 ubiquitin-like modifier activating enzyme 1 -2.93355
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -2.86875
SMC1A structural maintenance of chromosomes 1A -2.77227
PUDP pseudouridine 5'-phosphatase -2.7289
SMN2 survival of motor neuron 2, centromeric -2.7021
MRPL15 mitochondrial ribosomal protein L15 -2.6183
KDM5C lysine (K)-specific demethylase 5C -2.50625
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.4366
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) -2.35465
THSD1 thrombospondin, type I, domain containing 1 -2.3481
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.34415
HSDL2 hydroxysteroid dehydrogenase like 2 -2.34235
HAPSTR1 HUWE1 associated protein modifying stress responses -2.29015
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.2742
PNPLA4 patatin-like phospholipase domain containing 4 -2.25262
EDNRA endothelin receptor type A -2.20917
ARSL arylsulfatase L -2.1818
POU4F1 POU class 4 homeobox 1 -2.1689
CAPN2 calpain 2, (m/II) large subunit -2.14918
MTERF3 mitochondrial transcription termination factor 3 -2.14855
TMEM187 transmembrane protein 187 -2.12065
RLBP1 retinaldehyde binding protein 1 -2.11055
ALAD aminolevulinate dehydratase -2.10778
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.1069
CETN2 centrin, EF-hand protein, 2 -2.0996
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.093
OBI1 ORC ubiquitin ligase 1 -2.08925
KLF10 Kruppel-like factor 10 -2.07585
TBCCD1 TBCC domain containing 1 -2.06595
DENND1C DENN/MADD domain containing 1C -2.0561
LOC124906748 beta-defensin 4A -2.0393
ACTA2 actin, alpha 2, smooth muscle, aorta -2.03595
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.03495
DCHS2 dachsous cadherin-related 2 -2.03375
GRM2 glutamate receptor, metabotropic 2 -2.0259
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 -2.0213
UBA2 ubiquitin-like modifier activating enzyme 2 -2.0213
PRMT3 protein arginine methyltransferase 3 -2.01605
RAD51C RAD51 paralog C -2.01482
SLC44A1 solute carrier family 44 (choline transporter), member 1 -2.01165
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -2.00635
GADD45G growth arrest and DNA-damage-inducible, gamma -2.0035