CRCGN015_MCF10A.TP53.M_24H:K18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isobutyraldehyde 11.31 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:K18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 5.79315
LAGE3 L antigen family, member 3 5.6427
ZNF586 zinc finger protein 586 4.7553
ZNF134 zinc finger protein 134 4.53185
HLA-DRA major histocompatibility complex, class II, DR alpha 3.9062
HBA1 hemoglobin, alpha 1 3.8699
KLHL9 kelch-like family member 9 3.76433
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.75845
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3.64359
ZNF551 zinc finger protein 551 3.56135
ZNF211 zinc finger protein 211 3.52065
TBXA2R thromboxane A2 receptor 3.26723
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.12425
DENND2D DENN/MADD domain containing 2D 3.0815
TIAM1 T-cell lymphoma invasion and metastasis 1 3.06862
ZNF419 zinc finger protein 419 2.9473
GARRE1 granule associated Rac and RHOG effector 1 2.92745
ZNF587 zinc finger protein 587 2.7352
ZNF329 zinc finger protein 329 2.67245
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.6381
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.56825
TMEM204 transmembrane protein 204 2.5221
EBLN2 endogenous Bornavirus-like nucleoprotein 2 2.45355
FAM3A family with sequence similarity 3, member A 2.39935
ZNF304 zinc finger protein 304 2.3615
ZIM3 zinc finger, imprinted 3 2.3387
BCL9 B-cell CLL/lymphoma 9 2.31135
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.267
MTX1 metaxin 1 2.2277
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.22525
VBP1 von Hippel-Lindau binding protein 1 2.2144
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.2121
EVL Enah/Vasp-like 2.19945
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.1535
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.1376
ZNF606 zinc finger protein 606 2.1042
PTH1R parathyroid hormone 1 receptor 2.0992
APOO apolipoprotein O 2.0934
CRABP2 cellular retinoic acid binding protein 2 2.0806
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.05815
ZNF446 zinc finger protein 446 2.0355
ZNF268 zinc finger protein 268 2.03445
TLCD3A TLC domain containing 3A 2.0314
PCDH12 protocadherin 12 2.02395
ZNF544 zinc finger protein 544 2.0225
ZSCAN18 zinc finger and SCAN domain containing 18 2.0204
BPHL biphenyl hydrolase-like (serine hydrolase) 2.01155
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.0114
CD5L CD5 molecule-like 2.00135

decreased expression

Symbol Name Standardized Value
TRAPPC3 trafficking protein particle complex 3 -5.1795
HSPA8 heat shock 70kDa protein 8 -4.86427
CHMP4B charged multivesicular body protein 4B -4.63893
ANXA2 annexin A2 -4.59795
CAB39 calcium binding protein 39 -3.93845
HSPA1A heat shock 70kDa protein 1A -3.36555
PSRC1 proline/serine-rich coiled-coil 1 -3.33355
BID BH3 interacting domain death agonist -2.96165
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.74975
MRPS15 mitochondrial ribosomal protein S15 -2.611
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.41402
AGO1 argonaute RISC catalytic component 1 -2.34355
RTN3 reticulon 3 -2.33985
EIF3L eukaryotic translation initiation factor 3, subunit L -2.31185
CD81 CD81 molecule -2.2742
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -2.25895
BASP1 brain abundant, membrane attached signal protein 1 -2.18715
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -2.1069
DIABLO diablo, IAP-binding mitochondrial protein -2.0965
EEF2 eukaryotic translation elongation factor 2 -2.07075
NGRN neugrin, neurite outgrowth associated -2.04335
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.04275
HDAC4 histone deacetylase 4 -2.0073