CRCGN015_MCF10A.TP53.M_24H:K20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description kynurenic-acid 34.54 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:K20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 5.42472
KLHL21 kelch-like family member 21 4.80805
SPAG4 sperm associated antigen 4 4.66275
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.52833
LGMN legumain 3.7718
CA9 carbonic anhydrase IX 2.398
IL13RA1 interleukin 13 receptor, alpha 1 2.38324
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 2.37045
MINDY2 MINDY lysine 48 deubiquitinase 2 2.3697
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 2.3695
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.34095
PRR7 proline rich 7 (synaptic) 2.2803
SSBP3 single stranded DNA binding protein 3 2.2018
GYPC glycophorin C (Gerbich blood group) 2.1113
ZNF134 zinc finger protein 134 2.0646
METRN meteorin, glial cell differentiation regulator 2.043
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.0298
TBC1D31 TBC1 domain family, member 31 2.02755
VAMP3 vesicle-associated membrane protein 3 2.0264
LTF lactotransferrin 2.0225
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.0062

decreased expression

Symbol Name Standardized Value
CANT1 calcium activated nucleotidase 1 -5.58448
KIF14 kinesin family member 14 -5.39335
C2CD5 C2 calcium-dependent domain containing 5 -5.25415
ADI1 acireductone dioxygenase 1 -5.2245
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.142
HSPA1A heat shock 70kDa protein 1A -3.8796
ANKRD10 ankyrin repeat domain 10 -3.6733
CD320 CD320 molecule -2.89425
THAP11 THAP domain containing 11 -2.77565
IGF2R insulin-like growth factor 2 receptor -2.20893
TBPL1 TBP-like 1 -2.15555
ETNK1 ethanolamine kinase 1 -2.14737
NUBPL nucleotide binding protein-like -2.1342
IGFBP7 insulin-like growth factor binding protein 7 -2.1209
MANSC1 MANSC domain containing 1 -2.1201
CEP192 centrosomal protein 192kDa -2.0978
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.06665
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.06615
RPA3 replication protein A3, 14kDa -2.0622
SYNJ2BP synaptojanin 2 binding protein -2.057
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.0451
RGS2 regulator of G-protein signaling 2 -2.03515
RPL39L ribosomal protein L39-like -2.01975