CRCGN015_MCF10A.TP53.M_24H:K22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(2-chloroethyl) phosphate 100.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

157 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 5.95313
ANO10 anoctamin 10 4.76885
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.41307
GAA glucosidase, alpha; acid 4.36015
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 4.33765
HBB hemoglobin, beta 4.25485
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 4.12889
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.87155
MCUR1 mitochondrial calcium uniporter regulator 1 3.5997
APOE apolipoprotein E 3.42868
MDM4 MDM4, p53 regulator 3.2441
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.2322
BAG4 BCL2-associated athanogene 4 3.0497
CNRIP1 cannabinoid receptor interacting protein 1 2.96575
TFCP2L1 transcription factor CP2-like 1 2.76995
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.63386
MAIP1 matrix AAA peptidase interacting protein 1 2.6305
PECR peroxisomal trans-2-enoyl-CoA reductase 2.50155
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2.48245
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.46265
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.45645
ISOC1 isochorismatase domain containing 1 2.41945
FGG fibrinogen gamma chain 2.41765
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.2813
CNN2 calponin 2 2.2699
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.2589
FOXN2 forkhead box N2 2.25565
NRN1 neuritin 1 2.2511
STAT2 signal transducer and activator of transcription 2, 113kDa 2.22583
CAPN1 calpain 1, (mu/I) large subunit 2.2139
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.2047
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 2.1911
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.19085
F2R coagulation factor II (thrombin) receptor 2.17115
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.16872
GRHL2 grainyhead-like 2 (Drosophila) 2.1632
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.1627
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 2.15555
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.1445
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.13765
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.1274
IDI1 isopentenyl-diphosphate delta isomerase 1 2.12563
RAB20 RAB20, member RAS oncogene family 2.1129
FGB fibrinogen beta chain 2.1088
PTMA prothymosin, alpha 2.10592
MOGAT1 monoacylglycerol O-acyltransferase 1 2.10095
GSR glutathione reductase 2.086
RBM15 RNA binding motif protein 15 2.08403
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.08195
DPY19L4 dpy-19-like 4 (C. elegans) 2.07595
TARS1 threonyl-tRNA synthetase 1 2.07565
WDR76 WD repeat domain 76 2.07405
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.07265
TLK1 tousled-like kinase 1 2.06105
SPTSSA serine palmitoyltransferase, small subunit A 2.04603
SBNO1 strawberry notch homolog 1 (Drosophila) 2.03585
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 2.0237
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.0118
LYRM2 LYR motif containing 2 2.00715
RAB31 RAB31, member RAS oncogene family 2.00515

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -5.82105
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -4.96805
DNM1L dynamin 1-like -4.9677
COG2 component of oligomeric golgi complex 2 -4.4997
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.17163
PRPF4 pre-mRNA processing factor 4 -4.01927
KRT14 keratin 14, type I -3.967
CTNND1 catenin (cadherin-associated protein), delta 1 -3.94193
IFRD2 interferon-related developmental regulator 2 -3.91552
TOR1A torsin family 1, member A (torsin A) -3.78398
HSPA1A heat shock 70kDa protein 1A -3.71695
CREB1 cAMP responsive element binding protein 1 -3.62469
CAPRIN2 caprin family member 2 -3.5109
TMEM115 transmembrane protein 115 -3.31165
BPHL biphenyl hydrolase-like (serine hydrolase) -3.20945
BASP1 brain abundant, membrane attached signal protein 1 -2.9659
TM7SF3 transmembrane 7 superfamily member 3 -2.9514
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.8957
ALAD aminolevulinate dehydratase -2.88013
IL23A interleukin 23, alpha subunit p19 -2.86425
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.85105
RAP1B RAP1B, member of RAS oncogene family -2.75165
KDM3A lysine (K)-specific demethylase 3A -2.719
TUSC2 tumor suppressor candidate 2 -2.69517
TUBG1 tubulin, gamma 1 -2.6932
TGM4 transglutaminase 4 -2.6441
RWDD2A RWD domain containing 2A -2.6433
TMX2 thioredoxin-related transmembrane protein 2 -2.6275
THAP11 THAP domain containing 11 -2.6208
BARX2 BARX homeobox 2 -2.554
CCDC51 coiled-coil domain containing 51 -2.54245
ASB6 ankyrin repeat and SOCS box containing 6 -2.514
MYL5 myosin, light chain 5, regulatory -2.4902
ZNF189 zinc finger protein 189 -2.4822
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.46705
TCTN3 tectonic family member 3 -2.46607
NOP2 NOP2 nucleolar protein -2.4637
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit -2.4622
SURF2 surfeit 2 -2.45225
JMJD4 jumonji domain containing 4 -2.44485
DDA1 DET1 and DDB1 associated 1 -2.44065
MBD1 methyl-CpG binding domain protein 1 -2.43625
RECQL RecQ helicase-like -2.42718
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.38785
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like -2.3667
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.3554
KATNBL1 katanin p80 subunit B-like 1 -2.3536
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.3441
HROB homologous recombination factor with OB-fold -2.34195
SYNJ2BP synaptojanin 2 binding protein -2.3128
ZNF415 zinc finger protein 415 -2.3123
ARMC6 armadillo repeat containing 6 -2.3064
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.29846
TRIB3 tribbles pseudokinase 3 -2.2858
ARHGAP32 Rho GTPase activating protein 32 -2.28133
TSC1 tuberous sclerosis 1 -2.266
HINFP histone H4 transcription factor -2.261
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.25665
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -2.2461
CORT cortistatin -2.24105
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.2128
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.20875
GEMIN6 gem (nuclear organelle) associated protein 6 -2.2038
SGK1 serum/glucocorticoid regulated kinase 1 -2.19725
THAP3 THAP domain containing, apoptosis associated protein 3 -2.19665
BBS4 Bardet-Biedl syndrome 4 -2.18393
FAN1 FANCD2/FANCI-associated nuclease 1 -2.18015
BEX4 brain expressed, X-linked 4 -2.16105
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.15105
RAB27B RAB27B, member RAS oncogene family -2.14575
STK38L serine/threonine kinase 38 like -2.13735
MARK3 MAP/microtubule affinity-regulating kinase 3 -2.13305
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.1155
PLEKHA5 pleckstrin homology domain containing, family A member 5 -2.11165
PFKM phosphofructokinase, muscle -2.10875
TGM1 transglutaminase 1 -2.10565
ZNF175 zinc finger protein 175 -2.1014
SNX7 sorting nexin 7 -2.1008
KRI1 KRI1 homolog (S. cerevisiae) -2.10035
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.09865
MAEA macrophage erythroblast attacher -2.0967
ZNF79 zinc finger protein 79 -2.08525
ADIRF adipogenesis regulatory factor -2.08335
TOR1B torsin family 1, member B (torsin B) -2.0733
SH3GLB2 SH3-domain GRB2-like endophilin B2 -2.06025
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.0597
PTCD3 pentatricopeptide repeat domain 3 -2.0595
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.059
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.05785
MANF mesencephalic astrocyte-derived neurotrophic factor -2.046
CCDC106 coiled-coil domain containing 106 -2.04185
COQ9 coenzyme Q9 -2.0365
GUK1 guanylate kinase 1 -2.01305
CX3CR1 chemokine (C-X3-C motif) receptor 1 -2.0105
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -2.0052
RLN2 relaxin 2 -2.0041
TUBB2A tubulin, beta 2A class IIa -2.00393