CRCGN015_MCF10A.TP53.M_24H:L01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aflatoxin-b1 96.31 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

169 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:L01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RBKS ribokinase 5.10255
GLOD4 glyoxalase domain containing 4 4.43175
TICAM1 toll-like receptor adaptor molecule 1 4.42913
HBB hemoglobin, beta 4.18667
HBA1 hemoglobin, alpha 1 4.08271
SPAG4 sperm associated antigen 4 4.05503
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.86306
PPARG peroxisome proliferator-activated receptor gamma 3.67541
OXSR1 oxidative stress responsive 1 3.56897
CAPN1 calpain 1, (mu/I) large subunit 3.54161
DENND2D DENN/MADD domain containing 2D 3.46645
RGS2 regulator of G-protein signaling 2 3.4538
ATG2A autophagy related 2A 3.36387
INTS3 integrator complex subunit 3 3.33506
EAPP E2F-associated phosphoprotein 3.24397
STXBP1 syntaxin binding protein 1 3.22484
C2CD2 C2 calcium-dependent domain containing 2 3.06463
TCEA2 transcription elongation factor A (SII), 2 2.9915
PLA2G15 phospholipase A2, group XV 2.95031
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.93047
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.89976
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.77958
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.77812
GADD45B growth arrest and DNA-damage-inducible, beta 2.77639
SRP54 signal recognition particle 54kDa 2.74228
CCDC68 coiled-coil domain containing 68 2.7182
CXCR4 chemokine (C-X-C motif) receptor 4 2.69634
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.68578
GNB5 guanine nucleotide binding protein (G protein), beta 5 2.67967
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.6527
SPTSSA serine palmitoyltransferase, small subunit A 2.6455
GADD45G growth arrest and DNA-damage-inducible, gamma 2.61009
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 2.57923
CEMIP2 cell migration inducing hyaluronidase 2 2.57368
STX4 syntaxin 4 2.57142
PRR15L proline rich 15-like 2.56367
AMDHD2 amidohydrolase domain containing 2 2.55897
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.53071
MUC1 mucin 1, cell surface associated 2.46846
TMEM134 transmembrane protein 134 2.45419
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 2.4369
CAMTA2 calmodulin binding transcription activator 2 2.43183
XK X-linked Kx blood group 2.39972
NLRP2B NLR family pyrin domain containing 2B 2.37761
SKIC2 SKI2 subunit of superkiller complex 2.37506
CDKN2AIP CDKN2A interacting protein 2.35257
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.34026
CHIC2 cysteine-rich hydrophobic domain 2 2.33384
MRPL49 mitochondrial ribosomal protein L49 2.31994
CCS copper chaperone for superoxide dismutase 2.31902
ALAS1 5'-aminolevulinate synthase 1 2.30776
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.3035
CDPF1 cysteine-rich, DPF motif domain containing 1 2.29779
PNPO pyridoxamine 5'-phosphate oxidase 2.28739
GTPBP8 GTP-binding protein 8 (putative) 2.27502
NDEL1 nudE neurodevelopment protein 1-like 1 2.26158
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 2.24511
MAK16 MAK16 homolog (S. cerevisiae) 2.22428
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2.2115
CNOT7 CCR4-NOT transcription complex, subunit 7 2.20345
DDB1 damage-specific DNA binding protein 1, 127kDa 2.20123
PEX13 peroxisomal biogenesis factor 13 2.20049
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 2.18141
MSL2 male-specific lethal 2 homolog (Drosophila) 2.17364
CCNE1 cyclin E1 2.16747
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.16747
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.16478
WDR83OS WD repeat domain 83 opposite strand 2.15188
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 2.14425
TMEM11 transmembrane protein 11 2.14326
DDTL D-dopachrome tautomerase-like 2.13952
STAT5A signal transducer and activator of transcription 5A 2.13901
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 2.12622
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 2.12551
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 2.11243
SPATA20 spermatogenesis associated 20 2.11194
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.11062
ZNHIT3 zinc finger, HIT-type containing 3 2.08843
AARSD1 alanyl-tRNA synthetase domain containing 1 2.05206
HMGXB4 HMG box domain containing 4 2.04985
ABHD4 abhydrolase domain containing 4 2.02586
STAP2 signal transducing adaptor family member 2 2.02455
TDRD7 tudor domain containing 7 2.02345
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.02281
MYH9 myosin, heavy chain 9, non-muscle 2.00145
BBS1 Bardet-Biedl syndrome 1 2.0007

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -5.70757
NSDHL NAD(P) dependent steroid dehydrogenase-like -5.63981
PSRC1 proline/serine-rich coiled-coil 1 -5.45248
CCNB2 cyclin B2 -5.28012
KRT14 keratin 14, type I -5.22715
HSPA8 heat shock 70kDa protein 8 -4.68418
KIF20A kinesin family member 20A -4.26624
PLK1 polo-like kinase 1 -3.96425
PTK2 protein tyrosine kinase 2 -3.82926
CETN2 centrin, EF-hand protein, 2 -3.7142
TSPAN4 tetraspanin 4 -3.62017
NUSAP1 nucleolar and spindle associated protein 1 -3.4644
ANKRD10 ankyrin repeat domain 10 -3.35756
COG7 component of oligomeric golgi complex 7 -3.32018
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.30311
ANXA2 annexin A2 -3.29238
ZMIZ1 zinc finger, MIZ-type containing 1 -3.26381
MSRA methionine sulfoxide reductase A -3.16888
ASCC3 activating signal cointegrator 1 complex subunit 3 -3.13642
TIMP1 TIMP metallopeptidase inhibitor 1 -3.10113
MSMO1 methylsterol monooxygenase 1 -3.06633
PSIP1 PC4 and SFRS1 interacting protein 1 -3.04759
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.01202
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase -2.78858
GRB10 growth factor receptor-bound protein 10 -2.77588
PHGDH phosphoglycerate dehydrogenase -2.72867
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.69919
CDCA3 cell division cycle associated 3 -2.64836
HOXA5 homeobox A5 -2.63636
LBR lamin B receptor -2.63551
KDM3A lysine (K)-specific demethylase 3A -2.62387
COG2 component of oligomeric golgi complex 2 -2.6185
EPHB2 EPH receptor B2 -2.61328
ISOC2 isochorismatase domain containing 2 -2.57639
DERA deoxyribose-phosphate aldolase (putative) -2.54099
DDIT4 DNA-damage-inducible transcript 4 -2.49036
FN1 fibronectin 1 -2.48703
ANO10 anoctamin 10 -2.46738
IGFBP7 insulin-like growth factor binding protein 7 -2.46003
SNCAIP synuclein, alpha interacting protein -2.426
KRT5 keratin 5, type II -2.37789
CEP85 centrosomal protein 85kDa -2.37599
FLT4 fms-related tyrosine kinase 4 -2.35643
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -2.34693
EYA2 EYA transcriptional coactivator and phosphatase 2 -2.34683
NCAPD2 non-SMC condensin I complex, subunit D2 -2.33474
CBR3 carbonyl reductase 3 -2.3313
ZSCAN5A zinc finger and SCAN domain containing 5A -2.31488
NTAQ1 N-terminal glutamine amidase 1 -2.31039
UBL4A ubiquitin-like 4A -2.30556
MKI67 marker of proliferation Ki-67 -2.27202
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.25787
GHR growth hormone receptor -2.25564
KIF11 kinesin family member 11 -2.24988
MMP7 matrix metallopeptidase 7 -2.22743
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 -2.19306
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.14508
ZNF185 zinc finger protein 185 (LIM domain) -2.14251
CHODL chondrolectin -2.12713
CAPN2 calpain 2, (m/II) large subunit -2.12133
DNM1 dynamin 1 -2.11046
COL4A1 collagen, type IV, alpha 1 -2.10781
SMIM10L1 small integral membrane protein 10 like 1 -2.10489
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.10282
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -2.09424
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -2.09385
CENPE centromere protein E, 312kDa -2.09168
IL1RAP interleukin 1 receptor accessory protein -2.09093
ATAD2 ATPase family, AAA domain containing 2 -2.07951
SCARB1 scavenger receptor class B, member 1 -2.07682
PHC2 polyhomeotic homolog 2 (Drosophila) -2.07044
KIF23 kinesin family member 23 -2.06565
BZW2 basic leucine zipper and W2 domains 2 -2.06496
COL9A1 collagen, type IX, alpha 1 -2.06239
LMAN1L lectin, mannose-binding, 1 like -2.06055
COL7A1 collagen, type VII, alpha 1 -2.04984
NKRF NFKB repressing factor -2.04907
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -2.04899
TRAPPC3 trafficking protein particle complex 3 -2.04435
ACP3 acid phosphatase 3 -2.04084
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -2.02528
CLEC1A C-type lectin domain family 1, member A -2.00613
OXCT1 3-oxoacid CoA transferase 1 -2.00008