| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-phenyl-p-phenylenediamine.hcl 10.98 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
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148 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:L06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 5.0963 |
| MTA2 | metastasis associated 1 family, member 2 | 4.6699 |
| OXSR1 | oxidative stress responsive 1 | 4.52955 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 4.3234 |
| STK10 | serine/threonine kinase 10 | 4.24633 |
| GATA3 | GATA binding protein 3 | 4.13885 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | 3.80835 |
| CHN1 | chimerin 1 | 3.47175 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 3.4696 |
| ZNF451 | zinc finger protein 451 | 3.44832 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 3.2234 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 3.0256 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 2.89903 |
| HDHD5 | haloacid dehalogenase like hydrolase domain containing 5 | 2.84925 |
| EPHB2 | EPH receptor B2 | 2.84024 |
| FAM131A | family with sequence similarity 131, member A | 2.81965 |
| OSTF1 | osteoclast stimulating factor 1 | 2.73395 |
| PRR7 | proline rich 7 (synaptic) | 2.7077 |
| IFI6 | interferon, alpha-inducible protein 6 | 2.6766 |
| TMSB15B | thymosin beta 15B | 2.66845 |
| CEPT1 | choline/ethanolamine phosphotransferase 1 | 2.6608 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 2.58598 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | 2.5831 |
| NUTF2 | nuclear transport factor 2 | 2.54625 |
| ZNF672 | zinc finger protein 672 | 2.50865 |
| KIF21B | kinesin family member 21B | 2.4648 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 2.4634 |
| HAUS2 | HAUS augmin-like complex, subunit 2 | 2.4582 |
| HEXB | hexosaminidase B (beta polypeptide) | 2.4471 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.4163 |
| TLCD3A | TLC domain containing 3A | 2.40925 |
| EPPK1 | epiplakin 1 | 2.40675 |
| RIPOR1 | RHO family interacting cell polarization regulator 1 | 2.3945 |
| KLK1 | kallikrein 1 | 2.38945 |
| CLCA1 | chloride channel accessory 1 | 2.3811 |
| PRDM11 | PR domain containing 11 | 2.37415 |
| AMZ2 | archaelysin family metallopeptidase 2 | 2.37355 |
| ACBD3 | acyl-CoA binding domain containing 3 | 2.33432 |
| LSP1 | lymphocyte-specific protein 1 | 2.3341 |
| CWF19L1 | CWF19-like 1, cell cycle control (S. pombe) | 2.30705 |
| MDM4 | MDM4, p53 regulator | 2.2947 |
| CHP2 | calcineurin-like EF-hand protein 2 | 2.2878 |
| ICAM2 | intercellular adhesion molecule 2 | 2.26482 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | 2.25693 |
| RBBP5 | retinoblastoma binding protein 5 | 2.25425 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.24538 |
| DUSP8 | dual specificity phosphatase 8 | 2.21985 |
| RFPL3 | ret finger protein-like 3 | 2.2171 |
| TRABD | TraB domain containing | 2.2059 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 2.20525 |
| PRR3 | proline rich 3 | 2.1968 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 2.19058 |
| BTBD1 | BTB (POZ) domain containing 1 | 2.1788 |
| PITX3 | paired-like homeodomain 3 | 2.17575 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 2.1747 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 2.17428 |
| VIPR1 | vasoactive intestinal peptide receptor 1 | 2.17355 |
| STRN3 | striatin, calmodulin binding protein 3 | 2.17285 |
| CDX2 | caudal type homeobox 2 | 2.14875 |
| NFX1 | nuclear transcription factor, X-box binding 1 | 2.14662 |
| RFPL2 | ret finger protein-like 2 | 2.13195 |
| GRB7 | growth factor receptor-bound protein 7 | 2.12985 |
| CD207 | CD207 molecule, langerin | 2.11325 |
| DMBT1 | deleted in malignant brain tumors 1 | 2.1132 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 2.08057 |
| DCAF4 | DDB1 and CUL4 associated factor 4 | 2.07835 |
| DNAAF3 | dynein, axonemal, assembly factor 3 | 2.0724 |
| GRK6 | G protein-coupled receptor kinase 6 | 2.07014 |
| DAGLA | diacylglycerol lipase, alpha | 2.0515 |
| RAB31 | RAB31, member RAS oncogene family | 2.04987 |
| CCRL2 | chemokine (C-C motif) receptor-like 2 | 2.0493 |
| LY9 | lymphocyte antigen 9 | 2.0492 |
| INCENP | inner centromere protein antigens 135/155kDa | 2.04655 |
| EPS8L3 | EPS8-like 3 | 2.0428 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | 2.03335 |
| TDP1 | tyrosyl-DNA phosphodiesterase 1 | 2.0306 |
| REG3A | regenerating islet-derived 3 alpha | 2.0281 |
| FOXN3 | forkhead box N3 | 2.01993 |
| PLEK | pleckstrin | 2.01557 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 2.00343 |
| PGF | placental growth factor | 2.00042 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNDC9 | thioredoxin domain containing 9 | -5.76185 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -5.39285 |
| TRAPPC3 | trafficking protein particle complex 3 | -5.196 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | -4.7976 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -4.7866 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -4.59662 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | -4.00055 |
| TBCB | tubulin folding cofactor B | -3.81633 |
| ANKRD10 | ankyrin repeat domain 10 | -3.7872 |
| CETN2 | centrin, EF-hand protein, 2 | -3.7698 |
| UNC50 | unc-50 homolog (C. elegans) | -3.6577 |
| HOXA5 | homeobox A5 | -3.16945 |
| MRPS15 | mitochondrial ribosomal protein S15 | -3.15665 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -3.0694 |
| SEMA4C | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C | -3.06288 |
| EIF5B | eukaryotic translation initiation factor 5B | -2.93416 |
| CANT1 | calcium activated nucleotidase 1 | -2.8609 |
| TMEM147 | transmembrane protein 147 | -2.85665 |
| GOLGA7 | golgin A7 | -2.7166 |
| LIPT1 | lipoyltransferase 1 | -2.71215 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.70955 |
| ZNF146 | zinc finger protein 146 | -2.70825 |
| COX5B | cytochrome c oxidase subunit Vb | -2.65065 |
| SPAG1 | sperm associated antigen 1 | -2.60065 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | -2.5893 |
| COX6A1 | cytochrome c oxidase subunit VIa polypeptide 1 | -2.53935 |
| LIN37 | lin-37 DREAM MuvB core complex component | -2.5224 |
| PPL | periplakin | -2.51225 |
| LMAN2L | lectin, mannose-binding 2-like | -2.5072 |
| MEAF6 | MYST/Esa1-associated factor 6 | -2.46825 |
| SF3A3 | splicing factor 3a, subunit 3, 60kDa | -2.41335 |
| NAA10 | N(alpha)-acetyltransferase 10, NatA catalytic subunit | -2.3951 |
| CAPNS1 | calpain, small subunit 1 | -2.3564 |
| ANKRD46 | ankyrin repeat domain 46 | -2.33775 |
| THAP1 | THAP domain containing, apoptosis associated protein 1 | -2.3223 |
| FBXO3 | F-box protein 3 | -2.3122 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | -2.3025 |
| EMD | emerin | -2.2962 |
| VAMP8 | vesicle-associated membrane protein 8 | -2.29445 |
| ZNF444 | zinc finger protein 444 | -2.23705 |
| ORC4 | origin recognition complex, subunit 4 | -2.225 |
| GPATCH1 | G patch domain containing 1 | -2.18775 |
| ZNF761 | zinc finger protein 761 | -2.17815 |
| ZNF205 | zinc finger protein 205 | -2.1736 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | -2.16615 |
| SDHAF1 | succinate dehydrogenase complex assembly factor 1 | -2.16258 |
| RETREG3 | reticulophagy regulator family member 3 | -2.1503 |
| ARL5A | ADP-ribosylation factor-like 5A | -2.13225 |
| MSRB1 | methionine sulfoxide reductase B1 | -2.1287 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | -2.10925 |
| TMEM132A | transmembrane protein 132A | -2.102 |
| SSR4 | signal sequence receptor, delta | -2.09545 |
| ZNF593 | zinc finger protein 593 | -2.08695 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -2.0682 |
| F7 | coagulation factor VII (serum prothrombin conversion accelerator) | -2.05935 |
| NDUFA13 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 | -2.05825 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | -2.04635 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | -2.04558 |
| LAMTOR5 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 | -2.03673 |
| RPS5 | ribosomal protein S5 | -2.03545 |
| RIC8A | RIC8 guanine nucleotide exchange factor A | -2.03085 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | -2.0239 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -2.0175 |
| TMEM127 | transmembrane protein 127 | -2.0173 |
| LZTFL1 | leucine zipper transcription factor-like 1 | -2.01265 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | -2.0059 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | -2.00515 |
