CRCGN015_MCF10A.TP53.M_24H:L08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iq 31.94 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:L08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 5.324
SNAP25 synaptosomal-associated protein, 25kDa 5.1275
MCOLN1 mucolipin 1 4.908
CXCR4 chemokine (C-X-C motif) receptor 4 4.61918
SYN1 synapsin I 3.1772
SNPH syntaphilin 2.9794
CANT1 calcium activated nucleotidase 1 2.92097
PNPLA6 patatin-like phospholipase domain containing 6 2.8646
TPPP tubulin polymerization promoting protein 2.6384
COPS7A COP9 signalosome subunit 7A 2.627
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.6221
SV2B synaptic vesicle glycoprotein 2B 2.54325
AGR2 anterior gradient 2 2.51385
ZNF358 zinc finger protein 358 2.47145
ZNF574 zinc finger protein 574 2.4316
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.41415
STMN2 stathmin 2 2.40387
CENPE centromere protein E, 312kDa 2.3858
NSG2 neuronal vesicle trafficking associated 2 2.38265
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.34661
CCDC85B coiled-coil domain containing 85B 2.32065
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.3029
RNPS1 RNA binding protein S1, serine-rich domain 2.29198
CD180 CD180 molecule 2.28875
SNAP91 synaptosomal-associated protein, 91kDa 2.28855
CALCB calcitonin-related polypeptide beta 2.27835
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.1869
HMX1 H6 family homeobox 1 2.181
PCSK2 proprotein convertase subtilisin/kexin type 2 2.16197
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.13735
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.136
BLMH bleomycin hydrolase 2.1255
HDAC7 histone deacetylase 7 2.1199
RUNDC3A RUN domain containing 3A 2.1092
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.0926
CLDN1 claudin 1 2.0471
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.03645
DOLK dolichol kinase 2.02385
LAX1 lymphocyte transmembrane adaptor 1 2.0131
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.00655

decreased expression

Symbol Name Standardized Value
SGK1 serum/glucocorticoid regulated kinase 1 -5.44625
NUSAP1 nucleolar and spindle associated protein 1 -2.9606
RAB11FIP2 RAB11 family interacting protein 2 (class I) -2.58512
REXO2 RNA exonuclease 2 -2.54922
CD81 CD81 molecule -2.30895
ANKRD10 ankyrin repeat domain 10 -2.2805
RNF139 ring finger protein 139 -2.2118
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -2.14255
ELL3 elongation factor RNA polymerase II-like 3 -2.09757
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.09455
MARK1 MAP/microtubule affinity-regulating kinase 1 -2.02665
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) -2.02585
EHD4 EH-domain containing 4 -2.0106