CRCGN015_MCF10A.TP53.M_24H:L14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description etodolac 33.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:L14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 10.0
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.3244
SPAG4 sperm associated antigen 4 5.16765
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.0
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.97395
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 4.07285
METRN meteorin, glial cell differentiation regulator 3.99105
CCL2 chemokine (C-C motif) ligand 2 3.5335
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.03535
MTM1 myotubularin 1 3.0028
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.7359
C2CD2 C2 calcium-dependent domain containing 2 2.67995
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 2.42335
DSE dermatan sulfate epimerase 2.3719
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.36525
CPOX coproporphyrinogen oxidase 2.35485
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 2.31645
YAP1 Yes-associated protein 1 2.2978
LYRM1 LYR motif containing 1 2.2953
TNS2 tensin 2 2.26655
KRT81 keratin 81, type II 2.248
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.24577
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.21115
ZFYVE21 zinc finger, FYVE domain containing 21 2.16065
ERI2 ERI1 exoribonuclease family member 2 2.1351
AAR2 AAR2 splicing factor homolog (S. cerevisiae) 2.13375
SCAND1 SCAN domain containing 1 2.1266
MSRA methionine sulfoxide reductase A 2.08685
MFN1 mitofusin 1 2.075
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.07405
FAM171A1 family with sequence similarity 171, member A1 2.0683
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 2.05665
MED17 mediator complex subunit 17 2.05125
TMEM187 transmembrane protein 187 2.04675
NUBPL nucleotide binding protein-like 2.03745
CETN2 centrin, EF-hand protein, 2 2.01825

decreased expression

Symbol Name Standardized Value
TKT transketolase -3.99005
LYPLA1 lysophospholipase I -3.94742
CBR3 carbonyl reductase 3 -3.7143
HSPA1A heat shock 70kDa protein 1A -3.6983
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.69205
RBM34 RNA binding motif protein 34 -3.12122
ACAA1 acetyl-CoA acyltransferase 1 -3.07113
CXCL14 chemokine (C-X-C motif) ligand 14 -2.86945
PHLDA3 pleckstrin homology-like domain, family A, member 3 -2.739
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.5903
GZMM granzyme M (lymphocyte met-ase 1) -2.40985
CD81 CD81 molecule -2.30185
P3H3 prolyl 3-hydroxylase 3 -2.24835
RIGI RNA sensor RIG-I -2.23495
PDPN podoplanin -2.22187
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 -2.22045
CST1 cystatin SN -2.1837
TBCE tubulin folding cofactor E -2.168
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -2.15805
COTL1 coactosin-like F-actin binding protein 1 -2.1284
GSDMD gasdermin D -2.11395
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -2.109
CD247 CD247 molecule -2.08005
H2AC6 H2A clustered histone 6 -2.0687
PEX6 peroxisomal biogenesis factor 6 -2.03408
RAB25 RAB25, member RAS oncogene family -2.0275
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.02098