CRCGN015_MCF10A.TP53.M_24H:L15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description etodolac 11.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:L15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.21905
WFS1 Wolfram syndrome 1 (wolframin) 4.5864
FKBP14 FK506 binding protein 14, 22 kDa 4.55645
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.44255
PEX11A peroxisomal biogenesis factor 11 alpha 4.3091
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.11845
FGFR4 fibroblast growth factor receptor 4 3.93833
AGR2 anterior gradient 2 3.7738
WIF1 WNT inhibitory factor 1 3.55855
CCNA1 cyclin A1 3.38895
CNRIP1 cannabinoid receptor interacting protein 1 3.3819
TESK1 testis-specific kinase 1 3.28965
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 3.2011
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.13637
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.0765
DENND2D DENN/MADD domain containing 2D 3.05765
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.7245
TLCD3A TLC domain containing 3A 2.51025
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.50595
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.48995
BLMH bleomycin hydrolase 2.43585
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.4317
LGMN legumain 2.3678
ODF2 outer dense fiber of sperm tails 2 2.3263
DEK DEK proto-oncogene 2.3034
SLC75A1 solute carrier family 75 member 1 2.2627
SEC13 SEC13 homolog (S. cerevisiae) 2.22295
PYCR1 pyrroline-5-carboxylate reductase 1 2.21865
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.20495
YARS1 tyrosyl-tRNA synthetase 1 2.1678
LASP1 LIM and SH3 protein 1 2.1296
MARCKSL1 MARCKS-like 1 2.0558
ZNF556 zinc finger protein 556 2.0505
COQ8A coenzyme Q8A 2.0499
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.0318
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.0274
MGST2 microsomal glutathione S-transferase 2 2.0211
TMEM185B transmembrane protein 185B 2.0195

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.889
HSPA1A heat shock 70kDa protein 1A -5.76345
NPDC1 neural proliferation, differentiation and control, 1 -5.43925
RNF167 ring finger protein 167 -4.6553
LDHD lactate dehydrogenase D -4.57415
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.5353
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.821
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.78342
RBM34 RNA binding motif protein 34 -3.51067
C1QBP complement component 1, q subcomponent binding protein -3.0606
TNPO3 transportin 3 -2.90093
DERL2 derlin 2 -2.79295
PSRC1 proline/serine-rich coiled-coil 1 -2.77635
MSN moesin -2.7165
GAL3ST4 galactose-3-O-sulfotransferase 4 -2.70435
SYF2 SYF2 pre-mRNA-splicing factor -2.60825
UPP1 uridine phosphorylase 1 -2.57415
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.5125
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.4734
HYI hydroxypyruvate isomerase (putative) -2.47205
CRTAP cartilage associated protein -2.44675
TASL TLR adaptor interacting with endolysosomal SLC15A4 -2.44055
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.4025
RWDD1 RWD domain containing 1 -2.36205
NCKAP1L NCK-associated protein 1-like -2.3567
RINT1 RAD50 interactor 1 -2.35315
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -2.33987
CX3CR1 chemokine (C-X3-C motif) receptor 1 -2.3301
GCC1 GRIP and coiled-coil domain containing 1 -2.31615
MCTS1 malignant T cell amplified sequence 1 -2.28025
COTL1 coactosin-like F-actin binding protein 1 -2.2763
LEFTY1 left-right determination factor 1 -2.2408
GGT5 gamma-glutamyltransferase 5 -2.2364
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.2169
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.1992
NIBAN1 niban apoptosis regulator 1 -2.19917
COG5 component of oligomeric golgi complex 5 -2.16655
EVI2B ecotropic viral integration site 2B -2.1633
NAV2 neuron navigator 2 -2.1599
CSF1R colony stimulating factor 1 receptor -2.1504
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -2.12825
PDE9A phosphodiesterase 9A -2.12465
ARMCX1 armadillo repeat containing, X-linked 1 -2.1215
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.11955
MFSD12 major facilitator superfamily domain containing 12 -2.1058
GGPS1 geranylgeranyl diphosphate synthase 1 -2.10227
TRIP6 thyroid hormone receptor interactor 6 -2.0814
KLHDC10 kelch domain containing 10 -2.07695
LRRC8D leucine rich repeat containing 8 family, member D -2.07345
PHF20L1 PHD finger protein 20-like 1 -2.05275
MNT MAX network transcriptional repressor -2.044
XPA xeroderma pigmentosum, complementation group A -2.043
FYB1 FYN binding protein 1 -2.03643
MPDU1 mannose-P-dolichol utilization defect 1 -2.0243
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -2.02205
ZNF446 zinc finger protein 446 -2.0205
SAMD9 sterile alpha motif domain containing 9 -2.01925
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.01108
NFU1 NFU1 iron-sulfur cluster scaffold -2.005
CASP1 caspase 1, apoptosis-related cysteine peptidase -2.00019