CRCGN015_MCF10A.TP53.M_24H:L18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,3-dibromo-1-propanol 11.2 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:L18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TBX2 T-box 2 4.65542
KCTD5 potassium channel tetramerization domain containing 5 4.50725
FGFR4 fibroblast growth factor receptor 4 3.98195
ACAA1 acetyl-CoA acyltransferase 1 3.65868
HBB hemoglobin, beta 3.44033
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.38223
TERT telomerase reverse transcriptase 2.89705
KRI1 KRI1 homolog (S. cerevisiae) 2.49805
APOE apolipoprotein E 2.37227
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.3011
SATB1 SATB homeobox 1 2.27465
MAP3K7 mitogen-activated protein kinase kinase kinase 7 2.263
MEST mesoderm specific transcript 2.2048
AGER advanced glycosylation end product-specific receptor 2.17415
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.12705
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.10925
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.0955
PDLIM1 PDZ and LIM domain 1 2.0864
DENND2D DENN/MADD domain containing 2D 2.082
ADRA2B adrenoceptor alpha 2B 2.07245

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.6331
CD81 CD81 molecule -5.54315
HMG20B high mobility group 20B -5.19175
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.8048
MRPS2 mitochondrial ribosomal protein S2 -4.6783
BASP1 brain abundant, membrane attached signal protein 1 -4.65995
FOS FBJ murine osteosarcoma viral oncogene homolog -3.56545
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.2159
ATP11B ATPase, class VI, type 11B -2.72945
PAEP progestagen-associated endometrial protein -2.68395
MTERF3 mitochondrial transcription termination factor 3 -2.6371
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.63093
CDC42 cell division cycle 42 -2.62984
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.4989
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.44985
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.3372
CDC42SE1 CDC42 small effector 1 -2.3296
NGRN neugrin, neurite outgrowth associated -2.30425
RLF rearranged L-myc fusion -2.2322
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.1887
TP53 tumor protein p53 -2.05118
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.0223
RAB1B RAB1B, member RAS oncogene family -2.0196