CRCGN015_MCF10A.TP53.M_24H:L20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dichlorobenzidine 32.26 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

135 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:L20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 6.47505
RAB21 RAB21, member RAS oncogene family 5.3216
IL1B interleukin 1, beta 5.16485
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 5.1146
UGDH UDP-glucose 6-dehydrogenase 4.98435
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.96805
EVL Enah/Vasp-like 4.6166
FGFR4 fibroblast growth factor receptor 4 4.05155
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.67065
TBX2 T-box 2 3.60853
H2BC12 H2B clustered histone 12 3.554
CHN1 chimerin 1 3.3984
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.2509
WIF1 WNT inhibitory factor 1 3.12165
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.0769
IER3 immediate early response 3 3.01895
MARK4 MAP/microtubule affinity-regulating kinase 4 2.94028
BID BH3 interacting domain death agonist 2.92685
TNIP1 TNFAIP3 interacting protein 1 2.9185
CXCL3 chemokine (C-X-C motif) ligand 3 2.83775
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.7053
CEMIP2 cell migration inducing hyaluronidase 2 2.64185
KLHL9 kelch-like family member 9 2.6145
G0S2 G0/G1 switch 2 2.49855
SH2B3 SH2B adaptor protein 3 2.46055
H2BC5 H2B clustered histone 5 2.4095
TMEM74B transmembrane protein 74B 2.39475
H2BC9 H2B clustered histone 9 2.3852
TBC1D15 TBC1 domain family, member 15 2.3648
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.3645
NUCB2 nucleobindin 2 2.30925
CIAO2B cytosolic iron-sulfur assembly component 2B 2.30205
CADM1 cell adhesion molecule 1 2.27333
TRAPPC6A trafficking protein particle complex 6A 2.22625
ARL14 ADP-ribosylation factor-like 14 2.15655
ADRM1 adhesion regulating molecule 1 2.13545
KLC3 kinesin light chain 3 2.1322
H1-2 H1.2 linker histone, cluster member 2.1292
DLX2 distal-less homeobox 2 2.12635
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.0876
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.0645
HCCS holocytochrome c synthase 2.05907
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.049
MANF mesencephalic astrocyte-derived neurotrophic factor 2.0298
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.0265

decreased expression

Symbol Name Standardized Value
TXNDC9 thioredoxin domain containing 9 -5.49423
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.0194
DSG2 desmoglein 2 -4.976
ANKRD10 ankyrin repeat domain 10 -4.68095
MPC2 mitochondrial pyruvate carrier 2 -4.4349
ISOC1 isochorismatase domain containing 1 -4.1893
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -4.17605
CD81 CD81 molecule -4.10375
CRTAP cartilage associated protein -4.03065
OXCT1 3-oxoacid CoA transferase 1 -3.7904
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.74025
CD320 CD320 molecule -3.38455
NRIP1 nuclear receptor interacting protein 1 -3.34832
RPS5 ribosomal protein S5 -3.2118
FPGS folylpolyglutamate synthase -3.0362
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.02288
SPAG7 sperm associated antigen 7 -2.98535
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.9786
CRYL1 crystallin, lambda 1 -2.85545
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.8291
PCCB propionyl CoA carboxylase, beta polypeptide -2.816
IGFBP7 insulin-like growth factor binding protein 7 -2.7637
COXFA4 cytochrome c oxidase associated subunit FA4 -2.74955
COA3 cytochrome c oxidase assembly factor 3 -2.64385
DPY19L1 dpy-19-like 1 (C. elegans) -2.61055
PSRC1 proline/serine-rich coiled-coil 1 -2.5953
SESN1 sestrin 1 -2.5842
SUOX sulfite oxidase -2.58275
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.55245
ALDOC aldolase C, fructose-bisphosphate -2.52955
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 -2.51622
SNRPE small nuclear ribonucleoprotein polypeptide E -2.4555
PRR15L proline rich 15-like -2.4487
HOXA5 homeobox A5 -2.4187
TMEM14B transmembrane protein 14B -2.3803
PPA2 pyrophosphatase (inorganic) 2 -2.3624
TCEA2 transcription elongation factor A (SII), 2 -2.3523
PGM1 phosphoglucomutase 1 -2.3479
ZNHIT3 zinc finger, HIT-type containing 3 -2.34375
ADGRL3 adhesion G protein-coupled receptor L3 -2.30093
PCCA propionyl CoA carboxylase, alpha polypeptide -2.29595
DNM1 dynamin 1 -2.2834
QARS1 glutaminyl-tRNA synthetase 1 -2.28175
CDK1 cyclin-dependent kinase 1 -2.2702
HADH hydroxyacyl-CoA dehydrogenase -2.24922
CHST10 carbohydrate sulfotransferase 10 -2.2425
C2CD5 C2 calcium-dependent domain containing 5 -2.2287
TOP2A topoisomerase (DNA) II alpha 170kDa -2.2152
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.2079
RPL29 ribosomal protein L29 -2.20215
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -2.19553
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -2.19397
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.1926
FOXO4 forkhead box O4 -2.1843
ZNF606 zinc finger protein 606 -2.18135
PMF1-BGLAP PMF1-BGLAP readthrough -2.16215
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.1609
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -2.15975
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.15878
RPL19 ribosomal protein L19 -2.1534
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.15275
BASP1 brain abundant, membrane attached signal protein 1 -2.13605
RPS27L ribosomal protein S27-like -2.1352
MGST3 microsomal glutathione S-transferase 3 -2.131
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -2.1238
PIH1D1 PIH1 domain containing 1 -2.1148
CSK c-src tyrosine kinase -2.1117
ADGRE5 adhesion G protein-coupled receptor E5 -2.1075
CKS2 CDC28 protein kinase regulatory subunit 2 -2.10145
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.0973
RPL34 ribosomal protein L34 -2.09155
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -2.08915
RPL10A ribosomal protein L10a -2.08475
RPS8 ribosomal protein S8 -2.07535
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.0747
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -2.0744
ZNF510 zinc finger protein 510 -2.06755
NIT2 nitrilase family, member 2 -2.06745
TRAPPC2L trafficking protein particle complex 2-like -2.0522
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -2.04918
NUSAP1 nucleolar and spindle associated protein 1 -2.04437
TSPAN14 tetraspanin 14 -2.03985
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.0323
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 -2.0313
CDK4 cyclin-dependent kinase 4 -2.03
CBY1 chibby homolog 1 (Drosophila) -2.02285
C1GALT1C1 C1GALT1-specific chaperone 1 -2.01975
PLAC8 placenta-specific 8 -2.0147
GLDC glycine dehydrogenase (decarboxylating) -2.01425
NNT nicotinamide nucleotide transhydrogenase -2.01215