CRCGN015_MCF10A.TP53.M_24H:L23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description carbon-tetrachloride 32.77 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:L23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 5.008
RPL39L ribosomal protein L39-like 4.9425
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.90806
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.4861
MTA2 metastasis associated 1 family, member 2 3.89685
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.82225
COMP cartilage oligomeric matrix protein 3.7785
HBA1 hemoglobin, alpha 1 3.69542
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 3.47935
AGR2 anterior gradient 2 3.35625
CEPT1 choline/ethanolamine phosphotransferase 1 3.0825
NRBF2 nuclear receptor binding factor 2 2.7563
THRAP3 thyroid hormone receptor associated protein 3 2.7403
MDM4 MDM4, p53 regulator 2.65435
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.60895
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.4717
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.4658
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.4524
COMMD3-BMI1 COMMD3-BMI1 readthrough 2.44425
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.43295
SRSF6 serine/arginine-rich splicing factor 6 2.41565
NUTF2 nuclear transport factor 2 2.38065
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.35303
TJP1 tight junction protein 1 2.33783
SBNO1 strawberry notch homolog 1 (Drosophila) 2.31405
TBC1D31 TBC1 domain family, member 31 2.28655
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.27905
TRIM68 tripartite motif containing 68 2.27185
COMMD3 COMM domain containing 3 2.24995
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.24245
ZNF286A zinc finger protein 286A 2.2303
RBBP5 retinoblastoma binding protein 5 2.21835
IFI6 interferon, alpha-inducible protein 6 2.2108
ADRB2 adrenoceptor beta 2, surface 2.20975
SMYD5 SMYD family member 5 2.1435
STRN3 striatin, calmodulin binding protein 3 2.13703
TARP TCR gamma alternate reading frame protein 2.12304
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.1187
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.11298
GSR glutathione reductase 2.1093
ANKRD40 ankyrin repeat domain 40 2.0925
PRPF39 pre-mRNA processing factor 39 2.07845
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.0228

decreased expression

Symbol Name Standardized Value
PLK1 polo-like kinase 1 -5.5498
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0187
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -4.48282
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.40882
NPPB natriuretic peptide B -3.05315
RALGDS ral guanine nucleotide dissociation stimulator -2.8432
EXT1 exostosin glycosyltransferase 1 -2.73565
ARG2 arginase 2 -2.73115
RPA3 replication protein A3, 14kDa -2.5508
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.52805
TM4SF4 transmembrane 4 L six family member 4 -2.5159
SKA1 spindle and kinetochore associated complex subunit 1 -2.45445
WBP1L WW domain binding protein 1-like -2.42135
ILK integrin-linked kinase -2.40715
NARS1 asparaginyl-tRNA synthetase 1 -2.28485
BAAT bile acid CoA:amino acid N-acyltransferase -2.2538
CER1 cerberus 1, DAN family BMP antagonist -2.25115
SMAP1 small ArfGAP 1 -2.1836
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.1658
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 -2.15015
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog -2.13165
RPGR retinitis pigmentosa GTPase regulator -2.1046
RBFA ribosome binding factor A (putative) -2.08465
GLB1L2 galactosidase, beta 1-like 2 -2.05865
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.05185
RBBP8 retinoblastoma binding protein 8 -2.0445
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.0419
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.03905
SECTM1 secreted and transmembrane 1 -2.0337
SPX spexin hormone -2.0304
ADD3 adducin 3 (gamma) -2.03024
CD2AP CD2-associated protein -2.02055
ADORA2A adenosine A2a receptor -2.00765