CRCGN015_MCF10A.TP53.M_24H:M01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitromethane 99.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

181 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.52655
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.32168
CNRIP1 cannabinoid receptor interacting protein 1 5.29317
SPAG4 sperm associated antigen 4 5.12852
ADGRE5 adhesion G protein-coupled receptor E5 4.85142
PRR7 proline rich 7 (synaptic) 4.75091
UBQLN2 ubiquilin 2 4.62635
MAP7 microtubule-associated protein 7 4.61949
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.60955
PEX11A peroxisomal biogenesis factor 11 alpha 4.47897
AGR2 anterior gradient 2 4.4292
CXCR4 chemokine (C-X-C motif) receptor 4 4.41114
SSBP2 single-stranded DNA binding protein 2 4.3041
MAMLD1 mastermind-like domain containing 1 4.28261
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.18426
DPH2 DPH2 homolog (S. cerevisiae) 3.73394
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.45584
METRN meteorin, glial cell differentiation regulator 3.12326
CCL2 chemokine (C-C motif) ligand 2 3.10784
GATA3 GATA binding protein 3 2.9958
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.94959
TRAPPC4 trafficking protein particle complex 4 2.82196
WASF3 WAS protein family, member 3 2.57834
UBE4A ubiquitination factor E4A 2.46239
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.35651
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.31321
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.28718
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.2343
KAT6A K(lysine) acetyltransferase 6A 2.23259
EEIG1 estrogen-induced osteoclastogenesis regulator 1 2.23125
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 2.20453
MIDEAS mitotic deacetylase associated SANT domain protein 2.16451
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.14088
KIF4A kinesin family member 4A 2.12525
GLTP glycolipid transfer protein 2.11926
MFAP2 microfibrillar-associated protein 2 2.10531
NAP1L2 nucleosome assembly protein 1-like 2 2.07376
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.0679
RABIF RAB interacting factor 2.05386
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.05026
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 2.01865
TRAT1 T cell receptor associated transmembrane adaptor 1 2.01556
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.01374
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 2.01015
TSPYL1 TSPY-like 1 2.00715

decreased expression

Symbol Name Standardized Value
DERA deoxyribose-phosphate aldolase (putative) -5.268
TOPBP1 topoisomerase (DNA) II binding protein 1 -5.25926
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.1895
NPDC1 neural proliferation, differentiation and control, 1 -4.88042
FPGS folylpolyglutamate synthase -4.8282
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.7654
PARP2 poly (ADP-ribose) polymerase 2 -4.39455
COTL1 coactosin-like F-actin binding protein 1 -4.34009
PCNA proliferating cell nuclear antigen -4.30935
RNF167 ring finger protein 167 -4.29177
TUBB6 tubulin, beta 6 class V -4.26787
HMG20B high mobility group 20B -4.16124
ACOT9 acyl-CoA thioesterase 9 -3.86093
NLRP4 NLR family, pyrin domain containing 4 -3.56322
FASTKD5 FAST kinase domains 5 -3.51096
CD44 CD44 molecule (Indian blood group) -3.46715
APIP APAF1 interacting protein -3.45273
CAB39 calcium binding protein 39 -3.41414
CD58 CD58 molecule -3.15784
TMEM94 transmembrane protein 94 -2.95186
CD320 CD320 molecule -2.90896
ARPP19 cAMP-regulated phosphoprotein, 19kDa -2.90546
NBEAL2 neurobeachin-like 2 -2.8169
SYNPO2 synaptopodin 2 -2.77599
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.70434
IL21 interleukin 21 -2.64934
ATG3 autophagy related 3 -2.63249
SCIN scinderin -2.62998
CAPN2 calpain 2, (m/II) large subunit -2.61844
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.61471
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.60442
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -2.55029
PGM5 phosphoglucomutase 5 -2.54695
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.50704
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.50689
FAN1 FANCD2/FANCI-associated nuclease 1 -2.50073
PLVAP plasmalemma vesicle associated protein -2.49464
GPR19 G protein-coupled receptor 19 -2.47885
NECAB2 N-terminal EF-hand calcium binding protein 2 -2.44494
STX8 syntaxin 8 -2.43771
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.41941
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.41748
FZD10 frizzled class receptor 10 -2.41547
CRIPTO3 cripto, EGF-CFC family member 3 -2.4111
ACTG2 actin, gamma 2, smooth muscle, enteric -2.39031
FOXP3 forkhead box P3 -2.37746
HAND1 heart and neural crest derivatives expressed 1 -2.35562
IQCC IQ motif containing C -2.34237
CCDC177 coiled-coil domain containing 177 -2.33735
CLCNKB chloride channel, voltage-sensitive Kb -2.33207
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -2.32484
CPNE7 copine VII -2.32428
TACR2 tachykinin receptor 2 -2.32318
ENG endoglin -2.31623
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 -2.31252
ZNF8 zinc finger protein 8 -2.30838
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 -2.30731
AMZ2 archaelysin family metallopeptidase 2 -2.30651
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.30606
NUSAP1 nucleolar and spindle associated protein 1 -2.29335
PTGFR prostaglandin F receptor (FP) -2.2913
CDH5 cadherin 5, type 2 (vascular endothelium) -2.28188
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 -2.27978
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -2.27371
TCAP titin-cap -2.27104
HLA-DMB major histocompatibility complex, class II, DM beta -2.26226
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide -2.25301
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 -2.25061
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.24871
PHOX2B paired-like homeobox 2b -2.24733
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.24696
GREB1L growth regulation by estrogen in breast cancer-like -2.22015
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) -2.2197
KIRREL1 kirre like nephrin family adhesion molecule 1 -2.21915
CALCOCO1 calcium binding and coiled-coil domain 1 -2.21866
SLC35A5 solute carrier family 35, member A5 -2.21676
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -2.20715
LIF leukemia inhibitory factor -2.20159
MYOC myocilin, trabecular meshwork inducible glucocorticoid response -2.19098
MYOM1 myomesin 1 -2.18953
CNTN2 contactin 2 (axonal) -2.18507
HSF4 heat shock transcription factor 4 -2.1752
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 -2.16864
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.1675
HHIPL2 HHIP-like 2 -2.15429
OARD1 O-acyl-ADP-ribose deacylase 1 -2.15394
ZNF358 zinc finger protein 358 -2.1533
FAM163A family with sequence similarity 163, member A -2.14907
GFRA2 GDNF family receptor alpha 2 -2.13774
RAP1A RAP1A, member of RAS oncogene family -2.12941
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -2.12791
SNRK SNF related kinase -2.1276
CLDND1 claudin domain containing 1 -2.12602
CRMP1 collapsin response mediator protein 1 -2.12511
LRRC2 leucine rich repeat containing 2 -2.12499
CD93 CD93 molecule -2.11178
BCL2A1 BCL2-related protein A1 -2.10571
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.09865
ACKR5 atypical chemokine receptor 5 -2.09714
CD200 CD200 molecule -2.094
BARD1 BRCA1 associated RING domain 1 -2.09197
PIH1D1 PIH1 domain containing 1 -2.08833
MMP8 matrix metallopeptidase 8 -2.08788
CHRM3 cholinergic receptor, muscarinic 3 -2.08546
MYO5A myosin VA (heavy chain 12, myoxin) -2.08388
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 -2.0825
AKAP12 A kinase (PRKA) anchor protein 12 -2.08162
GPRIN2 G protein regulated inducer of neurite outgrowth 2 -2.07729
ATG14 autophagy related 14 -2.07422
TREM2 triggering receptor expressed on myeloid cells 2 -2.07016
CD86 CD86 molecule -2.06979
UBOX5 U-box domain containing 5 -2.06582
STK25 serine/threonine kinase 25 -2.06399
STMN4 stathmin-like 4 -2.06267
VAMP5 vesicle-associated membrane protein 5 -2.06142
WIPI1 WD repeat domain, phosphoinositide interacting 1 -2.05799
ALOX15 arachidonate 15-lipoxygenase -2.05416
LMO2 LIM domain only 2 (rhombotin-like 1) -2.05231
METTL25B methyltransferase like 25B -2.05179
ZNF133 zinc finger protein 133 -2.04929
PPP1R12B protein phosphatase 1, regulatory subunit 12B -2.04631
IPO13 importin 13 -2.04628
MYLK myosin light chain kinase -2.04014
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.03585
SIGLEC5 sialic acid binding Ig-like lectin 5 -2.03384
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.02392
TEC tec protein tyrosine kinase -2.01993
NGB neuroglobin -2.01686
FLCN folliculin -2.01605
MRPL37 mitochondrial ribosomal protein L37 -2.01408
CD81 CD81 molecule -2.01338
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 -2.0133
PECAM1 platelet/endothelial cell adhesion molecule 1 -2.01213
OMG oligodendrocyte myelin glycoprotein -2.0097
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.00529
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 -2.00164