CRCGN015_MCF10A.TP53.M_24H:M02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitromethane 33.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 5.21492
PRR7 proline rich 7 (synaptic) 4.83535
ABHD4 abhydrolase domain containing 4 4.72532
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 4.1646
STAP2 signal transducing adaptor family member 2 4.10679
RAB11FIP2 RAB11 family interacting protein 2 (class I) 4.0948
ADGRE5 adhesion G protein-coupled receptor E5 3.98543
ACAA1 acetyl-CoA acyltransferase 1 3.19072
SLC39A7 solute carrier family 39 (zinc transporter), member 7 3.01776
EMX2 empty spiracles homeobox 2 2.82851
WIF1 WNT inhibitory factor 1 2.78096
SPRED2 sprouty-related, EVH1 domain containing 2 2.76127
ACP2 acid phosphatase 2, lysosomal 2.67344
CCNA1 cyclin A1 2.54268
SPDEF SAM pointed domain containing ETS transcription factor 2.45067
NGF nerve growth factor (beta polypeptide) 2.43122
VANGL1 VANGL planar cell polarity protein 1 2.31691
AP1M2 adaptor-related protein complex 1, mu 2 subunit 2.31131
DUSP9 dual specificity phosphatase 9 2.23699
TBX19 T-box 19 2.15538
SOX5 SRY (sex determining region Y)-box 5 2.11678
IGSF1 immunoglobulin superfamily, member 1 2.09481
RSU1 Ras suppressor protein 1 2.07223
COPS7A COP9 signalosome subunit 7A 2.07127
LGMN legumain 2.05802
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 2.03937

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -4.97196
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.59966
RPS5 ribosomal protein S5 -4.20212
BLCAP bladder cancer associated protein -3.45222
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.41095
ZFYVE26 zinc finger, FYVE domain containing 26 -2.99467
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.98453
GRN granulin -2.85088
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.84301
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.6771
CD320 CD320 molecule -2.67168
ZNF410 zinc finger protein 410 -2.64952
HSPA1A heat shock 70kDa protein 1A -2.61766
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.6022
MKKS McKusick-Kaufman syndrome -2.56403
CBR3 carbonyl reductase 3 -2.55018
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.52051
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.4996
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.46976
TMEM230 transmembrane protein 230 -2.32401
MTX1 metaxin 1 -2.30667
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.29546
PLCB4 phospholipase C, beta 4 -2.23086
NSFL1C NSFL1 (p97) cofactor (p47) -2.21651
PRSS3 protease, serine, 3 -2.20121
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.18829
IL17RA interleukin 17 receptor A -2.16847
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.14492
RPA3 replication protein A3, 14kDa -2.13649
DENND4C DENN/MADD domain containing 4C -2.13138
MCM6 minichromosome maintenance complex component 6 -2.12488
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.09912
PLEK2 pleckstrin 2 -2.05952
PSEN1 presenilin 1 -2.05445
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.04463
PCCB propionyl CoA carboxylase, beta polypeptide -2.04424