CRCGN015_MCF10A.TP53.M_24H:M05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethyl hydrogen phosphite 33.43 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.9872
AKT1 v-akt murine thymoma viral oncogene homolog 1 4.27232
RPL39L ribosomal protein L39-like 4.11048
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.53985
IDE insulin-degrading enzyme 3.17329
RBKS ribokinase 2.96733
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.75736
ADSS2 adenylosuccinate synthase 2 2.61294
SIRT3 sirtuin 3 2.56599
TIAM1 T-cell lymphoma invasion and metastasis 1 2.55104
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.42082
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.31829
ACLY ATP citrate lyase 2.29893
TMEM134 transmembrane protein 134 2.26975
AKAP11 A kinase (PRKA) anchor protein 11 2.26415
FYN FYN proto-oncogene, Src family tyrosine kinase 2.23448
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.14586
F13A1 coagulation factor XIII, A1 polypeptide 2.14146
TBC1D3G TBC1 domain family member 3G 2.10757
C1RL complement component 1, r subcomponent-like 2.07618
CHN1 chimerin 1 2.0478
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.04027
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.03844
EXOC5 exocyst complex component 5 2.02675
ARID4B AT rich interactive domain 4B (RBP1-like) 2.00113

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -10.0
MRPS2 mitochondrial ribosomal protein S2 -4.94379
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.84722
PRPF4 pre-mRNA processing factor 4 -4.58176
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.452
CD320 CD320 molecule -4.2572
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.04538
HSPA1A heat shock 70kDa protein 1A -4.01006
MTERF3 mitochondrial transcription termination factor 3 -3.84939
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.78451
YME1L1 YME1-like 1 ATPase -3.71096
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -3.66442
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.20646
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -3.15355
UBE3C ubiquitin protein ligase E3C -3.13733
HMG20B high mobility group 20B -3.09575
PPP1R26 protein phosphatase 1, regulatory subunit 26 -3.07921
SSB Sjogren syndrome antigen B (autoantigen La) -2.95822
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.9499
FOS FBJ murine osteosarcoma viral oncogene homolog -2.90164
DCK deoxycytidine kinase -2.80501
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.75409
CETN2 centrin, EF-hand protein, 2 -2.71609
MZT2A mitotic spindle organizing protein 2A -2.68826
NGRN neugrin, neurite outgrowth associated -2.65616
KRT14 keratin 14, type I -2.63529
EMCN endomucin -2.50277
ZC3H15 zinc finger CCCH-type containing 15 -2.45256
UBAC1 UBA domain containing 1 -2.42904
NQO1 NAD(P)H dehydrogenase, quinone 1 -2.42887
LRP2 low density lipoprotein receptor-related protein 2 -2.37724
MTFR1 mitochondrial fission regulator 1 -2.3517
NT5DC2 5'-nucleotidase domain containing 2 -2.33344
MED22 mediator complex subunit 22 -2.31486
TMEM268 transmembrane protein 268 -2.29054
PAEP progestagen-associated endometrial protein -2.28576
ASB8 ankyrin repeat and SOCS box containing 8 -2.25246
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -2.25222
C4A complement component 4A (Rodgers blood group) -2.23031
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.22464
IPO13 importin 13 -2.21501
DCAF10 DDB1 and CUL4 associated factor 10 -2.20557
KCTD15 potassium channel tetramerization domain containing 15 -2.18476
ACVR1 activin A receptor, type I -2.17951
TMEM187 transmembrane protein 187 -2.16752
SLC10A3 solute carrier family 10, member 3 -2.15823
TCIM transcriptional and immune response regulator -2.15516
CPLX3 complexin 3 -2.15326
ZNF189 zinc finger protein 189 -2.1329
JADE3 jade family PHD finger 3 -2.12746
BSPRY B-box and SPRY domain containing -2.11957
FBXW2 F-box and WD repeat domain containing 2 -2.05886
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.05603
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.04668
USP19 ubiquitin specific peptidase 19 -2.03195
OTOR otoraplin -2.02895
BCAP31 B-cell receptor-associated protein 31 -2.02338
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.01842
ZNF467 zinc finger protein 467 -2.00584