CRCGN015_MCF10A.TP53.M_24H:M09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethynodrel 11.14 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

299 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 7.7157
WIF1 WNT inhibitory factor 1 6.05015
AGR2 anterior gradient 2 5.6091
TSEN2 TSEN2 tRNA splicing endonuclease subunit 5.413
CNRIP1 cannabinoid receptor interacting protein 1 5.0
RAP1GAP RAP1 GTPase activating protein 4.97735
UGDH UDP-glucose 6-dehydrogenase 4.97235
CXCR4 chemokine (C-X-C motif) receptor 4 4.84388
SYNGAP1 synaptic Ras GTPase activating protein 1 4.63802
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.49505
PPOX protoporphyrinogen oxidase 3.78565
GCLM glutamate-cysteine ligase, modifier subunit 3.6917
HMOX1 heme oxygenase 1 3.6511
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.64175
FHL2 four and a half LIM domains 2 3.44245
ACAA1 acetyl-CoA acyltransferase 1 3.35365
EMC3 ER membrane protein complex subunit 3 3.26305
TIAM1 T-cell lymphoma invasion and metastasis 1 3.15625
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.02793
GLRX glutaredoxin (thioltransferase) 2.97322
LRP10 low density lipoprotein receptor-related protein 10 2.91015
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.8588
TSPAN7 tetraspanin 7 2.8556
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.84315
DYNLT1 dynein, light chain, Tctex-type 1 2.83655
ASF1A anti-silencing function 1A histone chaperone 2.79638
SQSTM1 sequestosome 1 2.7549
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.72695
PPARG peroxisome proliferator-activated receptor gamma 2.71585
BHLHE40 basic helix-loop-helix family, member e40 2.68977
FTL ferritin, light polypeptide 2.6672
TSKU tsukushi, small leucine rich proteoglycan 2.65865
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.64475
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.6392
ADIPOR1 adiponectin receptor 1 2.6141
CALU calumenin 2.57461
TGFBI transforming growth factor, beta-induced, 68kDa 2.5663
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.56245
NUCB2 nucleobindin 2 2.54515
TALDO1 transaldolase 1 2.531
AKR1C3 aldo-keto reductase family 1, member C3 2.52185
BAG2 BCL2-associated athanogene 2 2.50175
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.48915
PDLIM1 PDZ and LIM domain 1 2.4877
IER3 immediate early response 3 2.47535
SNAP23 synaptosomal-associated protein, 23kDa 2.4631
CDPF1 cysteine-rich, DPF motif domain containing 1 2.4482
HBA1 hemoglobin, alpha 1 2.4397
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.43543
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.4347
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.43128
AKR1C1 aldo-keto reductase family 1, member C1 2.41763
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.4106
UPK1B uroplakin 1B 2.40755
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.40695
RHOB ras homolog family member B 2.401
COPB1 coatomer protein complex, subunit beta 1 2.36107
SNAI1 snail family zinc finger 1 2.33975
BLVRB biliverdin reductase B 2.3389
TSPAN13 tetraspanin 13 2.3375
EGR3 early growth response 3 2.33055
BBOF1 basal body orientation factor 1 2.30245
FMOD fibromodulin 2.29585
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.2901
ERGIC2 ERGIC and golgi 2 2.28545
NAGK N-acetylglucosamine kinase 2.27765
GHITM growth hormone inducible transmembrane protein 2.2557
BMAL2 basic helix-loop-helix ARNT like 2 2.2122
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.20275
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.1935
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.18185
ALAS2 5'-aminolevulinate synthase 2 2.1681
HMGA2 high mobility group AT-hook 2 2.1497
PNKP polynucleotide kinase 3'-phosphatase 2.14935
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.1493
SNX3 sorting nexin 3 2.14875
TMED3 transmembrane emp24 protein transport domain containing 3 2.1223
LMO2 LIM domain only 2 (rhombotin-like 1) 2.11485
ARF4 ADP-ribosylation factor 4 2.11243
ATP5F1E ATP synthase F1 subunit epsilon 2.10585
TMEM231 transmembrane protein 231 2.09833
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.09085
GLTP glycolipid transfer protein 2.08925
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 2.0879
KLF1 Kruppel-like factor 1 (erythroid) 2.0797
ARF1 ADP-ribosylation factor 1 2.07825
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.06595
TSPOAP1 TSPO associated protein 1 2.06405
SNRPN small nuclear ribonucleoprotein polypeptide N 2.06385
SEC16A SEC16 homolog A (S. cerevisiae) 2.0601
LOC112694756 uncharaterized LOC112694756 2.05557
CBR3 carbonyl reductase 3 2.0425
NCSTN nicastrin 2.03305
ARID3A AT rich interactive domain 3A (BRIGHT-like) 2.027
LOC128125822 uncharacterized LOC128125822 2.02599
MPC1 mitochondrial pyruvate carrier 1 2.0253
DUSP4 dual specificity phosphatase 4 2.0251
STX1A syntaxin 1A (brain) 2.0234
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.0185
PCID2 PCI domain containing 2 2.0163
UXS1 UDP-glucuronate decarboxylase 1 2.01135
MKRN2 makorin ring finger protein 2 2.00755
TMED2 transmembrane emp24 domain trafficking protein 2 2.00627
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.00595
ARFIP2 ADP-ribosylation factor interacting protein 2 2.00065

decreased expression

Symbol Name Standardized Value
CDC25B cell division cycle 25B -6.2991
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.3293
PUF60 poly-U binding splicing factor 60KDa -5.2273
CCDC86 coiled-coil domain containing 86 -5.0955
GTPBP8 GTP-binding protein 8 (putative) -4.90065
SLC25A46 solute carrier family 25, member 46 -4.76275
GRWD1 glutamate-rich WD repeat containing 1 -4.74855
TRAPPC3 trafficking protein particle complex 3 -4.22428
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.8267
MRPS15 mitochondrial ribosomal protein S15 -3.5985
NISCH nischarin -3.51695
ADRB2 adrenoceptor beta 2, surface -3.32305
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.31205
CAPN1 calpain 1, (mu/I) large subunit -3.27725
FOXM1 forkhead box M1 -3.10075
NCBP3 nuclear cap binding subunit 3 -3.08695
CD320 CD320 molecule -3.0455
GPR143 G protein-coupled receptor 143 -2.99035
CERT1 ceramide transporter 1 -2.93695
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.9142
PRPF19 pre-mRNA processing factor 19 -2.9043
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 -2.85725
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.8019
INTS9 integrator complex subunit 9 -2.79585
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.7922
BTBD2 BTB (POZ) domain containing 2 -2.77885
CREBL2 cAMP responsive element binding protein-like 2 -2.75757
CCNB2 cyclin B2 -2.72955
POMC proopiomelanocortin -2.7212
MAP7D1 MAP7 domain containing 1 -2.7029
SLC35A5 solute carrier family 35, member A5 -2.69495
BPHL biphenyl hydrolase-like (serine hydrolase) -2.66755
ZMYM4 zinc finger, MYM-type 4 -2.66618
COPS7B COP9 signalosome subunit 7B -2.6638
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.66375
ZNF35 zinc finger protein 35 -2.6568
FKBP5 FK506 binding protein 5 -2.64435
ASRGL1 asparaginase like 1 -2.60535
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit -2.60105
ZNF322 zinc finger protein 322 -2.59745
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.5914
EPHB6 EPH receptor B6 -2.58845
CASP1 caspase 1, apoptosis-related cysteine peptidase -2.57153
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.5608
OXCT1 3-oxoacid CoA transferase 1 -2.55655
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.529
GRAMD1C GRAM domain containing 1C -2.5201
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.517
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 -2.4999
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.48645
RRAGC Ras-related GTP binding C -2.4834
TBX19 T-box 19 -2.48335
RET ret proto-oncogene -2.47998
GFRA3 GDNF family receptor alpha 3 -2.44815
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -2.44535
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -2.44177
ELP5 elongator acetyltransferase complex subunit 5 -2.44145
FBXL6 F-box and leucine-rich repeat protein 6 -2.429
SLC38A10 solute carrier family 38, member 10 -2.4267
FHIT fragile histidine triad -2.41145
SCRIB scribbled planar cell polarity protein -2.3937
ASCL1 achaete-scute family bHLH transcription factor 1 -2.38823
YBX2 Y box binding protein 2 -2.38045
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.37805
FSCN3 fascin actin-bundling protein 3, testicular -2.37795
FSHB follicle stimulating hormone, beta polypeptide -2.3771
TRAPPC9 trafficking protein particle complex 9 -2.3673
OSBPL11 oxysterol binding protein-like 11 -2.3659
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.35811
PARN poly(A)-specific ribonuclease -2.35795
MKKS McKusick-Kaufman syndrome -2.35675
NOTCH1 notch 1 -2.3492
ZXDC ZXD family zinc finger C -2.34385
CDCA8 cell division cycle associated 8 -2.3363
SNRPA small nuclear ribonucleoprotein polypeptide A -2.32815
CLASRP CLK4-associating serine/arginine rich protein -2.31745
TBC1D15 TBC1 domain family, member 15 -2.30665
CAPN10 calpain 10 -2.30065
TRAP1 TNF receptor-associated protein 1 -2.2977
CENPB centromere protein B, 80kDa -2.297
PPA1 pyrophosphatase (inorganic) 1 -2.2964
INPP5B inositol polyphosphate-5-phosphatase, 75kDa -2.2941
CA9 carbonic anhydrase IX -2.28995
BMS1 BMS1 ribosome biogenesis factor -2.28335
ZNHIT2 zinc finger, HIT-type containing 2 -2.28195
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.2795
ACVR2B activin A receptor, type IIB -2.27805
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 -2.2699
SIPA1 signal-induced proliferation-associated 1 -2.26805
RNASE6 ribonuclease, RNase A family, k6 -2.26695
FANCC Fanconi anemia, complementation group C -2.2521
CD38 CD38 molecule -2.2485
MEN1 multiple endocrine neoplasia I -2.2476
KRT75 keratin 75, type II -2.2474
CD7 CD7 molecule -2.24085
MUC3B mucin 3B, cell surface associated -2.2336
CDC7 cell division cycle 7 -2.231
PRR15L proline rich 15-like -2.2303
FCGBP Fc fragment of IgG binding protein -2.228
KLF15 Kruppel-like factor 15 -2.21935
KLK5 kallikrein-related peptidase 5 -2.21735
KRT15 keratin 15, type I -2.21135
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 -2.2108
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -2.20915
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.20645
PIM2 Pim-2 proto-oncogene, serine/threonine kinase -2.20205
WDR7 WD repeat domain 7 -2.2018
PEPD peptidase D -2.20135
CTSD cathepsin D -2.2007
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -2.19935
SMG9 SMG9 nonsense mediated mRNA decay factor -2.1989
MXRA5 matrix-remodelling associated 5 -2.19745
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B -2.19677
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -2.19415
ARSA arylsulfatase A -2.19295
INCENP inner centromere protein antigens 135/155kDa -2.19125
STX12 syntaxin 12 -2.19103
BNC2 basonuclin 2 -2.18415
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -2.18297
CORO1A coronin, actin binding protein, 1A -2.1788
RIPK4 receptor-interacting serine-threonine kinase 4 -2.1773
PRODH proline dehydrogenase (oxidase) 1 -2.1771
SLC68A1 solute carrier family 68 member 1 -2.1753
AGO3 argonaute RISC catalytic component 3 -2.1744
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -2.17427
SAFB2 scaffold attachment factor B2 -2.16822
SETDB1 SET domain, bifurcated 1 -2.16048
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.15985
CD180 CD180 molecule -2.15895
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.1563
TMEM164 transmembrane protein 164 -2.15615
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -2.1518
KCNIP2 Kv channel interacting protein 2 -2.1502
TNP1 transition protein 1 (during histone to protamine replacement) -2.1501
TEX11 testis expressed 11 -2.1448
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.13855
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.13435
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.13185
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.12845
ZBTB48 zinc finger and BTB domain containing 48 -2.1274
IGFBP6 insulin-like growth factor binding protein 6 -2.11415
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.111
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 -2.1086
ZNF329 zinc finger protein 329 -2.0999
CD96 CD96 molecule -2.0955
THOP1 thimet oligopeptidase 1 -2.08735
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -2.08605
PHC2 polyhomeotic homolog 2 (Drosophila) -2.08595
CD300C CD300c molecule -2.0843
GPATCH3 G patch domain containing 3 -2.083
ZNF282 zinc finger protein 282 -2.07965
CASKIN2 CASK interacting protein 2 -2.06775
KIF20A kinesin family member 20A -2.0676
INTS5 integrator complex subunit 5 -2.06555
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.0646
THNSL2 threonine synthase-like 2 (S. cerevisiae) -2.06345
BLCAP bladder cancer associated protein -2.06345
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 -2.06302
TLN1 talin 1 -2.0549
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 -2.05445
RTN3 reticulon 3 -2.0503
AMH anti-Mullerian hormone -2.04725
GRK1 G protein-coupled receptor kinase 1 -2.04675
KLHDC3 kelch domain containing 3 -2.0465
SYMPK symplekin -2.04623
ST20-MTHFS ST20-MTHFS readthrough -2.04565
BEST1 bestrophin 1 -2.0433
ZNF219 zinc finger protein 219 -2.0426
PDE9A phosphodiesterase 9A -2.0419
AGO1 argonaute RISC catalytic component 1 -2.0408
ZNF354A zinc finger protein 354A -2.0402
CIC capicua transcriptional repressor -2.0399
LIME1 Lck interacting transmembrane adaptor 1 -2.0396
PODXL2 podocalyxin-like 2 -2.03905
JAG2 jagged 2 -2.03888
ZNF215 zinc finger protein 215 -2.0377
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.0329
CCHCR1 coiled-coil alpha-helical rod protein 1 -2.03201
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.02875
GSDMD gasdermin D -2.0282
GTPBP6 GTP binding protein 6 (putative) -2.0259
NDRG1 N-myc downstream regulated 1 -2.02515
CALY calcyon neuron-specific vesicular protein -2.02505
UPK3A uroplakin 3A -2.02305
UBXN2B UBX domain protein 2B -2.02175
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -2.02115
MEPCE methylphosphate capping enzyme -2.02035
BIK BCL2-interacting killer (apoptosis-inducing) -2.01945
TROAP trophinin associated protein -2.015
VEGFB vascular endothelial growth factor B -2.0135
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.01285
YARS1 tyrosyl-tRNA synthetase 1 -2.006
DOCK1 dedicator of cytokinesis 1 -2.00575
TSSK2 testis-specific serine kinase 2 -2.00235