CRCGN015_MCF10A.TP53.M_24H:M10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylhydrazine sulfate 100.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

18 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INTS3 integrator complex subunit 3 5.46825
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.65872
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.68665
GRB10 growth factor receptor-bound protein 10 3.53855
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.97275
AGR2 anterior gradient 2 2.7769
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.2316
MCUR1 mitochondrial calcium uniporter regulator 1 2.05675
BLMH bleomycin hydrolase 2.0476
GSTZ1 glutathione S-transferase zeta 1 2.0428

decreased expression

Symbol Name Standardized Value
CDC45 cell division cycle 45 -5.0709
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.6911
FBXO21 F-box protein 21 -3.44407
NLRP4 NLR family, pyrin domain containing 4 -3.25705
RGS2 regulator of G-protein signaling 2 -2.6355
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.20835
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.11107
PTPRK protein tyrosine phosphatase, receptor type, K -2.01715