CRCGN015_MCF10A.TP53.M_24H:M13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloroethane 96.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

101 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.50295
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.26962
MCOLN1 mucolipin 1 5.21105
ADGRE5 adhesion G protein-coupled receptor E5 5.0973
SSBP2 single-stranded DNA binding protein 2 5.05702
SPAG4 sperm associated antigen 4 4.87065
ABHD6 abhydrolase domain containing 6 4.7145
CDCA4 cell division cycle associated 4 3.98295
VAV3 vav 3 guanine nucleotide exchange factor 3.74633
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.43682
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.09902
TSPAN6 tetraspanin 6 2.8095
DNASE1L3 deoxyribonuclease I-like 3 2.7946
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.57335
TATDN2 TatD DNase domain containing 2 2.44005
ZNF143 zinc finger protein 143 2.4237
MRC1 mannose receptor, C type 1 2.39845
CTSW cathepsin W 2.3936
AAR2 AAR2 splicing factor homolog (S. cerevisiae) 2.2695
LOC102724594 splicing factor U2AF 35 kDa subunit 2.2628
SCAND1 SCAN domain containing 1 2.24375
UBE2E3 ubiquitin-conjugating enzyme E2E 3 2.2366
CCL13 chemokine (C-C motif) ligand 13 2.2196
PLAC8 placenta-specific 8 2.1358
NOP14 NOP14 nucleolar protein 2.1324
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 2.10995
ZNF266 zinc finger protein 266 2.1021
TACC3 transforming, acidic coiled-coil containing protein 3 2.0711
MAEA macrophage erythroblast attacher 2.06655
LYRM2 LYR motif containing 2 2.04185
CCL14 chemokine (C-C motif) ligand 14 2.03945
CLASRP CLK4-associating serine/arginine rich protein 2.0138
AKAP8 A kinase (PRKA) anchor protein 8 2.00542

decreased expression

Symbol Name Standardized Value
WASHC4 WASH complex subunit 4 -5.29277
PCNA proliferating cell nuclear antigen -5.0
C1QBP complement component 1, q subcomponent binding protein -4.85315
LYPLA1 lysophospholipase I -4.40595
RNF167 ring finger protein 167 -4.25465
SGK1 serum/glucocorticoid regulated kinase 1 -4.064
CD58 CD58 molecule -3.64018
BID BH3 interacting domain death agonist -3.4799
PANK2 pantothenate kinase 2 -3.25275
MTERF3 mitochondrial transcription termination factor 3 -3.00225
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.99905
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.92595
ACAA1 acetyl-CoA acyltransferase 1 -2.85637
MEGF8 multiple EGF-like-domains 8 -2.6336
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.61615
RNF24 ring finger protein 24 -2.58913
TEX14 testis expressed 14 -2.55345
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.54457
FAIM Fas apoptotic inhibitory molecule -2.5002
TMEM120B transmembrane protein 120B -2.48165
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.45
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.4317
PYCARD PYD and CARD domain containing -2.4185
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.3978
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -2.3832
TBK1 TANK-binding kinase 1 -2.3752
ZNF667 zinc finger protein 667 -2.3499
RB1CC1 RB1-inducible coiled-coil 1 -2.34618
EHD3 EH-domain containing 3 -2.33925
GDF7 growth differentiation factor 7 -2.29205
RPAP2 RNA polymerase II associated protein 2 -2.28895
ALOX12 arachidonate 12-lipoxygenase -2.2767
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.25237
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.24795
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.23725
ZNF133 zinc finger protein 133 -2.226
CEP83 centrosomal protein 83kDa -2.21985
OPRK1 opioid receptor, kappa 1 -2.21895
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -2.19495
KIAA1614 KIAA1614 -2.1944
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -2.1918
ERLIN2 ER lipid raft associated 2 -2.18925
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -2.1771
CD79B CD79b molecule, immunoglobulin-associated beta -2.1701
CNPY4 canopy FGF signaling regulator 4 -2.15605
CLCNKB chloride channel, voltage-sensitive Kb -2.1368
MMP26 matrix metallopeptidase 26 -2.13235
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -2.13147
SLC44A1 solute carrier family 44 (choline transporter), member 1 -2.1291
UPK1A uroplakin 1A -2.1239
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.09685
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.0887
ARSJ arylsulfatase family, member J -2.08535
MAP6D1 MAP6 domain containing 1 -2.07345
SCPEP1 serine carboxypeptidase 1 -2.069
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase -2.0626
ZNF862 zinc finger protein 862 -2.06155
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) -2.05823
MYF5 myogenic factor 5 -2.0554
BDKRB1 bradykinin receptor B1 -2.05525
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -2.05185
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.0448
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -2.0415
CALHM2 calcium homeostasis modulator 2 -2.02332
TRIM22 tripartite motif containing 22 -2.01335
CKAP4 cytoskeleton-associated protein 4 -2.0127
SEC23B Sec23 homolog B (S. cerevisiae) -2.0083
KIF3C kinesin family member 3C -2.00262