CRCGN015_MCF10A.TP53.M_24H:M14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloroethane 32.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO10 anoctamin 10 5.34885
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.79155
RAB11FIP2 RAB11 family interacting protein 2 (class I) 4.61955
WIF1 WNT inhibitory factor 1 4.46325
GATA2 GATA binding protein 2 4.39005
DENND2D DENN/MADD domain containing 2D 2.88945
TOMM34 translocase of outer mitochondrial membrane 34 2.87195
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.7539
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.64175
TBC1D31 TBC1 domain family, member 31 2.62885
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.36055
KLHL21 kelch-like family member 21 2.35085
ATP5PO ATP synthase peripheral stalk subunit OSCP 2.20965
ZMYND11 zinc finger, MYND-type containing 11 2.06845
CNRIP1 cannabinoid receptor interacting protein 1 2.067

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -5.33805
HMG20B high mobility group 20B -4.90735
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.55715
RNF167 ring finger protein 167 -4.42065
PSIP1 PC4 and SFRS1 interacting protein 1 -3.74268
PSRC1 proline/serine-rich coiled-coil 1 -3.53
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.29095
TOR1A torsin family 1, member A (torsin A) -3.15425
ELAC2 elaC ribonuclease Z 2 -2.67855
HOXA5 homeobox A5 -2.6497
CMTR1 cap methyltransferase 1 -2.3728
MED28 mediator complex subunit 28 -2.303
IRF2 interferon regulatory factor 2 -2.2097
COTL1 coactosin-like F-actin binding protein 1 -2.0893
MT1X metallothionein 1X -2.0639
ZMYM2 zinc finger, MYM-type 2 -2.04077