CRCGN015_MCF10A.TP53.M_24H:M18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cadmium chloride 11.14 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

105 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 5.2953
MAMLD1 mastermind-like domain containing 1 4.6215
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.2394
TBX2 T-box 2 4.05305
OXSR1 oxidative stress responsive 1 3.56875
HBA1 hemoglobin, alpha 1 3.50481
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.46382
KDM5D lysine (K)-specific demethylase 5D 3.4393
USP9Y ubiquitin specific peptidase 9, Y-linked 3.2478
SIRT3 sirtuin 3 3.22567
CCNA1 cyclin A1 3.21735
EPN2 epsin 2 2.95762
CCDC85B coiled-coil domain containing 85B 2.8741
TPD52L2 tumor protein D52-like 2 2.87
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.84935
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.83165
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 2.5998
C2CD2 C2 calcium-dependent domain containing 2 2.59725
NLGN4Y neuroligin 4, Y-linked 2.553
ZFY zinc finger protein, Y-linked 2.53605
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.51715
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.5164
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 2.5037
LOC102724560 cystathionine beta-synthase 2.46
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.423
CADM1 cell adhesion molecule 1 2.40858
MTM1 myotubularin 1 2.4033
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.36295
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.36125
LOC122526780 uncharacterized LOC122526780 2.3477
AMT aminomethyltransferase 2.34005
PRKCE protein kinase C, epsilon 2.29195
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 2.284
FCHO1 FCH domain only 1 2.2807
LSAMP limbic system-associated membrane protein 2.2524
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.2463
PHF14 PHD finger protein 14 2.24255
METTL4 methyltransferase like 4 2.2243
DYNC2I1 dynein 2 intermediate chain 1 2.21965
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.21577
MNS1 meiosis-specific nuclear structural 1 2.20465
ERO1B endoplasmic reticulum oxidoreductase 1 beta 2.20355
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.20235
CA3 carbonic anhydrase III 2.1956
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2.186
RASAL2 RAS protein activator like 2 2.1728
RIC8A RIC8 guanine nucleotide exchange factor A 2.17165
UBAP1 ubiquitin associated protein 1 2.15925
TYW2 tRNA wybutosine-synthesizing protein 2 2.1538
KLHL12 kelch-like family member 12 2.14435
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.14145
MAN2C1 mannosidase, alpha, class 2C, member 1 2.1354
CRELD2 cysteine-rich with EGF-like domains 2 2.13385
BARX2 BARX homeobox 2 2.10465
HDAC5 histone deacetylase 5 2.10285
NOVA1 neuro-oncological ventral antigen 1 2.10083
AGBL5 ATP/GTP binding protein-like 5 2.0981
MSTN myostatin 2.09345
NME5 NME/NM23 family member 5 2.09285
H2BC21 H2B clustered histone 21 2.08855
ABI2 abl-interactor 2 2.08162
PEDS1 plasmanylethanolamine desaturase 1 2.0796
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 2.07613
FBXO11 F-box protein 11 2.07363
IFT140 intraflagellar transport 140 2.05965
KCNK2 potassium channel, two pore domain subfamily K, member 2 2.05865
ARG2 arginase 2 2.0516
TAS2R4 taste receptor, type 2, member 4 2.04365
DENND2B DENN domain containing 2B 2.03555
USP53 ubiquitin specific peptidase 53 2.02995
THNSL1 threonine synthase-like 1 (S. cerevisiae) 2.0209
PTH2R parathyroid hormone 2 receptor 2.01825
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.0163
IFT70A intraflagellar transport 70A 2.0161
NEK11 NIMA-related kinase 11 2.0084
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.00135

decreased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 -4.84295
CDK4 cyclin-dependent kinase 4 -4.605
HOXA5 homeobox A5 -4.466
WASHC4 WASH complex subunit 4 -4.05215
NGRN neugrin, neurite outgrowth associated -3.4385
ANKRD10 ankyrin repeat domain 10 -3.42325
USP9X ubiquitin specific peptidase 9, X-linked -3.19987
ACAA1 acetyl-CoA acyltransferase 1 -3.03137
SMC1A structural maintenance of chromosomes 1A -3.0183
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -3.00776
KDM5C lysine (K)-specific demethylase 5C -2.8679
UBA1 ubiquitin-like modifier activating enzyme 1 -2.75345
MORC4 MORC family CW-type zinc finger 4 -2.60715
PUDP pseudouridine 5'-phosphatase -2.54995
COG4 component of oligomeric golgi complex 4 -2.5211
ATP11B ATPase, class VI, type 11B -2.41865
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.3582
DCK deoxycytidine kinase -2.33895
RPS5 ribosomal protein S5 -2.33305
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 -2.2657
MRPL48 mitochondrial ribosomal protein L48 -2.26015
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.17547
GCN1 GCN1 activator of EIF2AK4 -2.12313
UBE4A ubiquitination factor E4A -2.11715
TP53 tumor protein p53 -2.07425
ERP29 endoplasmic reticulum protein 29 -2.07395
ARCN1 archain 1 -2.0569
CD164 CD164 molecule, sialomucin -2.05275
TM2D3 TM2 domain containing 3 -2.05155