CRCGN015_MCF10A.TP53.M_24H:M19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description mestranol 97.87 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

81 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.41545
ABHD6 abhydrolase domain containing 6 5.3661
CXCR4 chemokine (C-X-C motif) receptor 4 4.78352
STAP2 signal transducing adaptor family member 2 4.6908
CNPY3 canopy FGF signaling regulator 3 4.50575
TBPL1 TBP-like 1 3.70555
BAMBI BMP and activin membrane-bound inhibitor 3.66955
KDM5D lysine (K)-specific demethylase 5D 3.04405
MSRA methionine sulfoxide reductase A 3.0367
FSD1 fibronectin type III and SPRY domain containing 1 2.8159
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.77825
PPARD peroxisome proliferator-activated receptor delta 2.75087
NINL ninein-like 2.6655
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.66243
USP9Y ubiquitin specific peptidase 9, Y-linked 2.58013
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.4266
ELOVL4 ELOVL fatty acid elongase 4 2.3941
FBXL12 F-box and leucine-rich repeat protein 12 2.38335
CHEK2 checkpoint kinase 2 2.37367
HYOU1 hypoxia up-regulated 1 2.35185
AFAP1 actin filament associated protein 1 2.3501
CR2 complement component (3d/Epstein Barr virus) receptor 2 2.3285
ALOX12B arachidonate 12-lipoxygenase, 12R type 2.324
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 2.30923
ZFY zinc finger protein, Y-linked 2.2863
KLHDC2 kelch domain containing 2 2.28135
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.2714
CNTN6 contactin 6 2.23865
ELSPBP1 epididymal sperm binding protein 1 2.22035
IL33 interleukin 33 2.1968
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.1904
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.15403
USP53 ubiquitin specific peptidase 53 2.15085
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.1176
EPHA4 EPH receptor A4 2.11265
DENND2B DENN domain containing 2B 2.1114
CENPQ centromere protein Q 2.06785
UBA5 ubiquitin-like modifier activating enzyme 5 2.0606
DTWD1 DTW domain containing 1 2.0535
NLGN4Y neuroligin 4, Y-linked 2.0364
THOC5 THO complex 5 2.02805
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 2.02375
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 2.0217
TSHR thyroid stimulating hormone receptor 2.01455
FRMD4A FERM domain containing 4A 2.01137
NCK2 NCK adaptor protein 2 2.0106
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.0064
SMC6 structural maintenance of chromosomes 6 2.0017

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -5.17835
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -4.53645
GADD45B growth arrest and DNA-damage-inducible, beta -4.37462
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -3.4526
CPNE3 copine III -3.3799
SMC1A structural maintenance of chromosomes 1A -2.93043
THAP11 THAP domain containing 11 -2.7883
REXO2 RNA exonuclease 2 -2.74219
CDR2L cerebellar degeneration-related protein 2-like -2.61075
MTERF3 mitochondrial transcription termination factor 3 -2.57965
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.51555
KDM5C lysine (K)-specific demethylase 5C -2.4772
ADRB2 adrenoceptor beta 2, surface -2.46055
CDC42 cell division cycle 42 -2.4497
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 -2.38485
MVP major vault protein -2.31635
RAB1B RAB1B, member RAS oncogene family -2.2481
SNX6 sorting nexin 6 -2.2283
CERS6 ceramide synthase 6 -2.22657
GTPBP8 GTP-binding protein 8 (putative) -2.21995
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.19635
TMOD1 tropomodulin 1 -2.13823
ZNF593 zinc finger protein 593 -2.13225
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.07995
CBR3 carbonyl reductase 3 -2.07765
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -2.07595
UBA1 ubiquitin-like modifier activating enzyme 1 -2.05045
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.04164
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.02905
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.02885
NENF neudesin neurotrophic factor -2.0277
MISP mitotic spindle positioning -2.02175
SH3D19 SH3 domain containing 19 -2.00955