CRCGN015_MCF10A.TP53.M_24H:M21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description mestranol 10.87 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:M21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 4.36455
CDCA4 cell division cycle associated 4 4.0673
TBX2 T-box 2 4.06282
ZNF134 zinc finger protein 134 3.4038
PDLIM1 PDZ and LIM domain 1 3.17975
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.04875
ADAT1 adenosine deaminase, tRNA-specific 1 2.69405
PECR peroxisomal trans-2-enoyl-CoA reductase 2.50105
ZNF551 zinc finger protein 551 2.3684
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.27625
LGMN legumain 2.2713
ZNF419 zinc finger protein 419 2.22692
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like 2.14265
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.1219
COMP cartilage oligomeric matrix protein 2.1216
GALNS galactosamine (N-acetyl)-6-sulfatase 2.0713
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.0323

decreased expression

Symbol Name Standardized Value
HSPA8 heat shock 70kDa protein 8 -5.43363
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.29955
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.1984
UFM1 ubiquitin-fold modifier 1 -5.0
C2CD5 C2 calcium-dependent domain containing 5 -4.9671
SPAG7 sperm associated antigen 7 -4.4406
NGRN neugrin, neurite outgrowth associated -2.82775
RPS5 ribosomal protein S5 -2.3763
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.33327
UNKL unkempt family zinc finger-like -2.32455
SEC24C SEC24 family member C -2.32115
CCDC51 coiled-coil domain containing 51 -2.30015
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.29805
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -2.211
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.1402
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.08595
ZC3H7A zinc finger CCCH-type containing 7A -2.07075
SQSTM1 sequestosome 1 -2.04803
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 -2.0262
EIF3D eukaryotic translation initiation factor 3, subunit D -2.0158